What medication has less side effects prolia or reclast (zoledronic acid)?

Prolia. Both medications are anti-resorptive, meaning they prevent breakdown of your bone. Reclast (zoledronic acid) has been used for longer so has more side-effects that are known. It also can not be used if you have kidney problems. Prolia is an injection every 6 months (vs. 12 months with reclast). Both medications tend to be very well tolerated.