Absolutely. The liver detoxifies alcohol and is greatly effected over time with some users developing cirrhosis. Brain cells are lost from drinking and never regenerate. Virtually every chronic condition is worsened by alcohol use, not to mention falls, fights, and car accidents that occur in greater frequency when individuals are intoxicated.
Yes. Alcohol can adversely effect every organ in the body except the kidneys. Sometimes the organs damaged from alcohol can repair themselves, if the damage is not too bad already. This would apply to the liver for example. Lab tests can be done to determine the extent of such damage. Other organs, like the brain do not repair themselves and the damage from alcohol can become permanent. See your dr.