Does Azo affect a drug screen?

Sorry, but azo what? Azo can mean many things. Please be more specific and resubmit your question and we will do our best to answer it. Thank you very much.
My guess is you. Are referring to pyridium, which is the sold over the counter as Azo for urinary pain.

Pyridium will color the urine, but will not effect the immunoassay results of the drug screen. The results will not change.

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