4 doctors weighed in:

Would neurofibromatosis type 1 disqualify me from donating sperm to a sperm bank?

4 doctors weighed in
Dr. Scott McLean
Clinical Genetics
1 doctor agrees

In brief: Probably

As you know, neurofibromatosis type 1 (nf1) can affect some people mildly, but in others it can cause serious birth defects.
The chance that a sperm donor might pass the nf1 mutation to his biological child is 50% for each pregnancy. This would probably be considered an excessively high risk, so i suspect that sperm (and egg) donors with confirmed nf1 would not be invited to donate.

In brief: Probably

As you know, neurofibromatosis type 1 (nf1) can affect some people mildly, but in others it can cause serious birth defects.
The chance that a sperm donor might pass the nf1 mutation to his biological child is 50% for each pregnancy. This would probably be considered an excessively high risk, so i suspect that sperm (and egg) donors with confirmed nf1 would not be invited to donate.
Dr. Scott McLean
Dr. Scott McLean
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Dr. Gerald Mandell
Nuclear Medicine

In brief: Probably

Therefore 1 in 1500 are new cases.
Neurofibromatosis type 1 is considered to have an autosomal dominant pattern of inheritance. People with this condition are born with one mutated copy of the NF1 gene in each cell. In about half of cases, the altered gene is inherited from an affected parent. Estimated incidence of NF1 is 1 in 3000. Approximately half of affected individuals represent first cases in the family as a result of a new genetic event or mutation.

In brief: Probably

Therefore 1 in 1500 are new cases.
Neurofibromatosis type 1 is considered to have an autosomal dominant pattern of inheritance. People with this condition are born with one mutated copy of the NF1 gene in each cell. In about half of cases, the altered gene is inherited from an affected parent. Estimated incidence of NF1 is 1 in 3000. Approximately half of affected individuals represent first cases in the family as a result of a new genetic event or mutation.
Dr. Gerald Mandell
Dr. Gerald Mandell
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In brief: Yes

You will be disqualified as a sperm donor, during screening process.
Sperm bank will not accept people with any genetic disorders. Nf-1 is a genetic disorder involving chromosome 17, formerly known as ' von recklinghausen disease '.

In brief: Yes

You will be disqualified as a sperm donor, during screening process.
Sperm bank will not accept people with any genetic disorders. Nf-1 is a genetic disorder involving chromosome 17, formerly known as ' von recklinghausen disease '.
Dr. Addagada Rao
Dr. Addagada Rao
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