Can Zoloft (sertraline) decrease the effects of adderall? Or could I be gaining a tolerance to adderall?

Agree w Dr. Pappas. Per Drugs.Com drug interaction checker - drug interaction checker > Adderall (amphetamine / dextroamphetamine) plus Zoloft (sertraline) may ^ risk for serotonergic syndrome. May also ^ side effects of nervousness, anxiety, racing thoughts and restlessness. However, it is usually safe together.
Not decrease. In some cases zoloft (sertraline) can accentuate -- not decrease -- the effects of stimulants. Please discuss these issues with your psychiatrist.

Related Questions

I took a Zoloft (sertraline) and then adderall, are there any drug interractions?

Potentially. Per Drugs.Com -" Sertraline may increase the effects of amphetamine, and side effects such as jitteriness, nervousness, anxiety, restlessness, and racing thoughts have been reported. Combining these medications can also increase the risk of a rare but serious condition called the serotonin syndrome." However, I often use this combination without any problems. Read more...