A myelofibrosis patient with enlarged liver&spleen been told transplant no option as I've 1in2 chance of fatality. On jak2, is death where I'm heading?

Myelofibrosis. We are all heading to death, the timing of when is the question. In your case you have a bad disease and predictions of progression are really not cogent from out here. You should discuss your situation with the drs. Who know you best.