16 doctors weighed in:

What's the difference between small cell and non-small cell lung cancer?

16 doctors weighed in
Dr. Liawaty Ho
Internal Medicine - Hematology & Oncology
6 doctors agree

In brief: Everything

Small cell lung cancer is almost completely different than non small cell- the only thing the same is that it is located on the lung and may give the same symptoms.
They are different in molecular biology level, they look and behave differently. Small cell behaves more agressive- like systemic disease even from the first presentation; have different treatment and prognosis .D/w your oncologist.

In brief: Everything

Small cell lung cancer is almost completely different than non small cell- the only thing the same is that it is located on the lung and may give the same symptoms.
They are different in molecular biology level, they look and behave differently. Small cell behaves more agressive- like systemic disease even from the first presentation; have different treatment and prognosis .D/w your oncologist.
Dr. Liawaty Ho
Dr. Liawaty Ho
Thank
Dr. Gurmukh Singh
Pathology
4 doctors agree

In brief: Both Bad

Small cell cancer often spread early in the course of disease and is treated with chemotherapy.
Early non-small cell carcinomas may be localized to the lung and be treatable with surgery and radiation.

In brief: Both Bad

Small cell cancer often spread early in the course of disease and is treated with chemotherapy.
Early non-small cell carcinomas may be localized to the lung and be treatable with surgery and radiation.
Dr. Gurmukh Singh
Dr. Gurmukh Singh
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Dr. Carlo Hatem
Internal Medicine - Pulmonary Critical Care
3 doctors agree

In brief: Clinical behavior

Small cell grows rapidly, and seems more susceptible to chemotherapy and radiation.
Non-small cell actually refers to a number of different types that are usually less aggressive and less sensitive to chemotherapy. Non-small cell has a different staging and treatment algorithm compared to small cell. Small cell is almost never treated with surgery.

In brief: Clinical behavior

Small cell grows rapidly, and seems more susceptible to chemotherapy and radiation.
Non-small cell actually refers to a number of different types that are usually less aggressive and less sensitive to chemotherapy. Non-small cell has a different staging and treatment algorithm compared to small cell. Small cell is almost never treated with surgery.
Dr. Carlo Hatem
Dr. Carlo Hatem
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Dr. Andrew Turrisi
Radiation Oncology

In brief: Clinical, molecular

& therapeutic. Both caused by tobacco 90 -100%; molecular too complex for here.
Chemotherapy mainstay in sclc, + rt in the limited kind, and proven role to prevent brain relapse; surgery in early stage of nsclc, chemo/rt when mediastinum infested; chemo alone for stage iv.

In brief: Clinical, molecular

& therapeutic. Both caused by tobacco 90 -100%; molecular too complex for here.
Chemotherapy mainstay in sclc, + rt in the limited kind, and proven role to prevent brain relapse; surgery in early stage of nsclc, chemo/rt when mediastinum infested; chemo alone for stage iv.
Dr. Andrew Turrisi
Dr. Andrew Turrisi
Thank
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