How is Zanaflex (tizanidine) different than flexeril?

Zanaflex (tizanidine) vs.Flexeril. Flexeril differs from the other centrally acting agents because it is structurally and pharmacologically related to amitriptyline, a tricyclic antidepressant. Zanaflex (tizanidine) is an alpha adrenergic agonist that inhibits the release of NE from the locus ceruleus in the brain.
Several ways. Both medications are muscle relaxants. Zanaflex is the brand name for tizanidine. Flexeril (cyclobenzaprine hcl) is the brand name for cyclobenzaprine. Neither of these medications truly relaxes the muscle. They work on the central nervous system (brain and/or spinal cord) to create 'relaxation' of the muscle. As a result , the common side effect of drowsiness can be problematic.

Related Questions

I take Zanaflex (tizanidine) or flexeril (have both) and just started necon 10/11. I read there could be interactions with zanaflex (tizanidine). Do I need to be concerned?

Yes- Sedation/dizzy. If you use Zanaflex (tizanidine) chronically, know that the concentration of Zanaflex is increased when used with oral contraceptive and may result in increased sedation, fatigue/ low blood pressure (hypotensive issues- dizziness, fainting). You may want to use Flexeril (cyclobenzaprine hcl) instead but also watch out for drowsiness, fatigue, dizziness. Avoid alcohol and use caution when driving while on these drugs. Read more...
Yes, it is possible. Zanaflex (tizanidine) & Flexeril are muscle relaxants, while Necon 10/11 is an oral contraceptive.All the three medications are metabolized in the liver through cyp450. Necon is an inhibitor of 3a4 sub-enzyme, while Zanaflex (tizanidine) and Flexeril are not. Necon may increase the levels of Flexeril and zanaflex, (tizanidine) causing increased sedation, dizziness, impairment of fine motor movements, coordination and risk of fall. Read more...

How long should I wait between zanaflex (tizanidine) and flexeril? I have started taking zanaflex (tizanidine) during the day but it doesn't cut it for my leg cramps at night.

8 hours. You should wait 8 hours after taking a zanaflex (tizanidine) before you take a flexeril. Make sure you are drinking plenty of water and taking a multivitamin/multimineral. Dehydration and vitamin/mineral deficiencies can contribute to muscle cramping. Stretching daily also helps muscles not to cramp. Read more...

Is Soma or Zanaflex (tizanidine) more effective than flexeril? For torticollus and back pain. I've had all kinds of labs and scans, im merely curious

Best medication. The best one is the one that works best (for you). I think Zanaflex (tizanidine) is a great muscle relaxer. Some is essentially a tranquilizer....So i would avoid it. If Flexeril is not helping then by all means try a different medication. Read more...

What muscle relaxant would you prescribe for chronic neck & back pain? Soma, zanaflex, (tizanidine) flexeril?

None of above. Medications should not be ordered until pathology is understood. Read more...
See below. I avoid Soma as it is essentially a tranquilizer, not a muscle relaxer. Both Zanaflex and Flexeril are good medications. There best one is the one that works best for you. Other options (less sedating) are Baclofen and skelaxin (metaxalone). Read more...

Severe muscle cramps. Feet, legs, groin, neck, shoulders, every nigh. Tried flexaril, zanaflex, (tizanidine) k, even lidoderm. Have sent lab test. What now?

Are you on. Any cholesterol lowering meds? That could cause this. I would also check potassium levels and magnesium deficiency. (need to check magnesium levels in the red blood cells.), there are other causes but i'd check these. Read more...
What kind of test? The results may help diagnose the underlying problem. If there is no abnormalities, PT, stretching, a different exercise regimen may help. Read more...