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Doctor insights on: Zoloft Vicodin Interaction

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Dr. Heidi Fowler
1,094 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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I'm going through Zoloft (sertraline) withdrawal and I take Vicodin. Will taking Vicodin stop or slow the recovery process from coming off of Zoloft (sertraline)?

I'm going through Zoloft (sertraline) withdrawal and I take Vicodin. Will taking Vicodin stop or slow the recovery process from coming off of Zoloft (sertraline)?

No: These two medications act on the body in separate ways, so the use of Vicodin is not recommended for symptoms of withdrawal from Zoloft (sertraline). I would recommend that you discuss this with the Doctor who prescribed the Zoloft (sertraline) so that you can be appropriately weaned off the Zoloft (sertraline), if it is indicated. ...Read more

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Can I take vicodin for back pain while I'm taking zoloft (sertraline)?

Can I take vicodin for back pain while I'm taking zoloft (sertraline)?

Yes if prescribed: Yes you can if prescribed by your doctor, you can. ...Read more

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Is it safe to take vicodin while on Zoloft (sertraline) and breastfeeding?

Possibly: Vicodin and zoloft (sertraline) are often used together safely. However, these medications can both be in breast milk. It is important that you speak to your ob/gyn and/or your pediatrician about this issue. ...Read more

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Is it safe to take robaxin 500mg 2x a day, trazodone 50mg, Zoloft (sertraline) 50 mg, ibuprofen 800 4x a day, and vicodin 5/500mg every 8-10 hrs together?

Is it safe to take robaxin 500mg 2x a day, trazodone 50mg, Zoloft (sertraline) 50 mg, ibuprofen 800 4x a day, and vicodin 5/500mg every 8-10 hrs together?

Ask your doctor: Each of the listed medications may cause side effects and there is a possibility for drug-drug interaction. Discuss this regime with your prescribing doctor as there may be extenuating circumstances that justify this regimen. Vicodin may lead to tolerance, dependance and addiction. Ibuprofen 4 x a day may lead to serious side effects. ...Read more

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I'm having a problem starting urination for drug tests and sometimes at home, I take zanex, methadone, zooloft and vicadin 4 pain & depression asap luv?

I'm having a problem starting urination for drug tests and sometimes at home, I take zanex, methadone, zooloft and vicadin 4 pain & depression asap luv?

A lot of meds: All the meds you mention could potentially cause urinary hesitancy and retention especially when taken all togeter. Discuss this with your prescribing doc. ...Read more

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I take zoloft, (sertraline) are there any interactions between Zoloft (sertraline) and herbalife shakes?

I take zoloft, (sertraline) are there any interactions between Zoloft (sertraline) and herbalife shakes?

Zoloft (sertraline) and herbs: When taking zoloft, (sertraline) be careful not to take St John's wart ginkgo biloba, 5 ht and l-tryptophan as they can increase serotonin. Check if herbalife products contain these ingredients. ...Read more

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I'm prescribed 50mg of Zoloft (sertraline) and 10mg daytrana. Should I worry about the interactions of the three?

I'm prescribed 50mg of Zoloft (sertraline) and 10mg daytrana. Should I worry about the interactions of the three?

Zoloft/daytrana: Daytrana and zoloft (sertraline) are often prescribed together. The only interaction is that Daytrana can increase zoloft (sertraline) levels in the blood. This varies from person to person. If you have a mood disorder and adhd, you also need to consider the treatment for adhd can worsen your mood. If you have both issues, I would recommend that you see a psychiatrist who can treat both and be aware of conflicts. ...Read more

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I am presently taking Risperdal and now I am being put back on my Zoloft (sertraline) should I worry bout any interactions?

I am presently taking Risperdal and now I am being put back on my Zoloft (sertraline) should I worry bout any interactions?

Not particularly: Should not be much to worry about with risperidone. Technically both work on the aspects of the serotonin system but should not affect how each other are broken down. I am not aware of any absolute contraindications of being on both ...Read more

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What are the interactions between Zoloft (sertraline) and melatonin if any?

What are the interactions between Zoloft (sertraline) and melatonin if any?

Zoloft/Melatonin: No interactions. Only caution when taking melatonin is if u r on medications that suppress the immune system, blood thinners, diabetes medications, & birth control pills. ...Read more

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Can I take zoloft and miralax together? Drugs. Com says it causes an interaction

Can I take zoloft and miralax together? Drugs. Com says it causes an interaction

Interaction: Just consider separating the times you take the Zoloft and the Miralax. That should be plenty to rid of any direct interaction. ...Read more

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Seretide acuhealer 125 mg x2 a day + Zoloft (sertraline) 200mg if no interactions?

Med Interactions: There is no specific contraindication and I would assume your doctor who prescribed is aware of your other medications. If you are still worried, please ask the prescribing doctor since they know you best and the reason (s) for prescribing your medications. ...Read more

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Any interaction btween Zoloft Abilify (aripiprazole) trazadon busparone?

Any interaction btween Zoloft Abilify (aripiprazole) trazadon busparone?

Potentially: Combination of Zoloft, trazodone & buspar can increased potential for serotonergic reactions which can be severe. Trazodone or zoloft when mixed with abilify can ^ risk for sedation, dizziness or confusion. ...Read more

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Witch mor interactions with many drugs Zoloft or Cymbalta (duloxetine) and witch more safe between them?

Neither: Well one is not generally safer then the other, it all depends on which works for you. It also depends on what you are treating and what other medications you are on.
...Read more

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I take lopressor 37.5 mg and zoloft (sertraline) 25mg. Is it safe to use together, like there is now interactions?

I take lopressor 37.5 mg and zoloft (sertraline) 25mg. Is it safe to use together, like there is now interactions?

Discuss w/ Dr: Zoloft (sertraline) can exaggerate the effects of the lopressor so it's important for your doctor to check you more frequently to be sure dosage is appropriate. Work together on any combinations of medications to be safe. Best! ...Read more

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Does Zoloft (sertraline) cause weight gain? Are there any interactions with Zoloft (sertraline) and st. John's wort?

Does Zoloft (sertraline) cause weight gain? Are there any interactions with Zoloft (sertraline) and st. John's wort?

Probaly Not: There is no strong association between zoloft (sertraline) and weight gain but depression can cause loss of appetite and treatment may cause it to return.
Do not take st. Johns wort, its affects are additive to zoloft (sertraline) and might cause a condition called serotonin syndrome or neuroleptic malignant syndrome. ...Read more

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My pdoc prescribed me wellbutrin (bupropion) and I take lithium and zoloft. What are the interactions when I take the meds? What should I expect?

My pdoc prescribed me wellbutrin (bupropion) and I take lithium and zoloft. What are the interactions when I take the meds? What should I expect?

Depends on dose: Zoloft and wellbutrin (bupropion) are moderate, dose-related inhibitors of cyp450 2d6 for which zoloft partly depends upon for its metabolism. Zoloft usually only inhibits 2d6 at higher doses (150-200mg). It might be worthy to be genotyped for this enzyme to assure you are a extensive metobolizer (em) type. Lithium is mostly excreted unchanged by kidneys. Please follow-up regularly with your doctor. ...Read more

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Do you think taking Le-Vel Thrive and Zoloft (sertraline) at the same time would cause interactions?

Unknown interactions: Le Vel Thrive is a product marketed to promote weight loss, energy and improved mood and focus. It reportedly contains vitamins, minerals, herbal supplements, enzymes and antioxidants designed to produce lean muscle and mental clarity. However, such claims have not been endorsed by the FDA. This means that there may be unknown adverse interactions if taken with antidepressants such as Zoloft (sertraline). ...Read more

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There any interaction between Zoloft (sertraline) 50mg and Risperdal 0.25 and remeron 15mg?? And can bi combine together?

There any interaction between Zoloft (sertraline) 50mg and Risperdal 0.25 and remeron 15mg?? And can bi combine together?

Discuss w/ provider: Hopefully the same doctor prescribed these or they consulted if it was not. There is a potential problem (serotonin syndrome) when Zoloft (sertraline) and Remeron are taken in combo. So, make sure this is the best treatment plan available to you since it needs close monitoring. They all interact w/ each other in a non-major way that can increase dizzy, drowsy, confused effects so be careful w/ what you do. ...Read more

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Can I take valerian root at night before bed while taking 25mg Zoloft (sertraline) daily? Is it safe? Or are there interactions?

Can I take valerian root at night before bed while taking 25mg Zoloft (sertraline) daily? Is it safe? Or are there interactions?

Be careful: As you say you'd be taking the Valerian at bedtime, the fact that the combo can cause drowsiness, inability to concentrate and dizziness may not be too disturbing - but it can also increase a risk of respiratory depression - so if you have any breathing issues I'd avoid it and if you feel even a bit of such problems cease use immediately. I'd try warm milk or a boring book instead. Best! . ...Read more

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Can vyvanse (lisdexamfetamine) and luvox have interactions and if so what are they? Also is there an interaction between vyvanse (lisdexamfetamine) and zoloft?

Can vyvanse (lisdexamfetamine) and luvox have interactions and if so what are they? Also is there an interaction between vyvanse (lisdexamfetamine) and zoloft?

Yes. But: Luvox and Zoloft (SSRI meds) can interact with Vyvanse (lisdexamfetamine) to boost the effects of Vyvanse (lisdexamfetamine) possibly giving you more side effects such as jitteriness, tremor. But the combination is fairly common, effective and safe with careful medical supervision. I hope this helps. ...Read more

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I have been on 40mg betapace (sotalol) 2x day for years. Zoloft for about 5 months. Up to 100mg. Any interactions? Dr. Says no pharmacy says maybe. Scared

I have been on 40mg betapace (sotalol) 2x day for years. Zoloft for about 5 months. Up to 100mg. Any interactions? Dr. Says no pharmacy says maybe. Scared

Yes: Taking them together can increase the risk of changes in heartbeat and heart rhythm. I'd discuss your concerns with your physician. He knows your medical history. ...Read more

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Does Zoloft (sertraline) and Doxycycline have any interactions?

Does Zoloft (sertraline) and Doxycycline have any interactions?

No: No interactions reported, but always let a prescribing doctor know about your other medications. It really helps them serve you best. ...Read more

Dr. Heidi Fowler
1,048 Doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more


Dr. Alan Wartenberg
844 Doctors shared insights

Hydrocodone And Acetaminophen (Definition)

Hydrocodone|acetaminophen is a narcotic combination for pain which is a ...Read more