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Doctor insights on: Zoloft Dosage For Anxiety

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Dr. Heidi Fowler
3,157 doctors shared insights

Anxiety (Definition)

Anxiety is a general term for several disorders that cause nervousness, fear, apprehension, and worrying. These disorders affect how we feel and behave, and they can manifest real physical symptoms. Mild anxiety is vague and unsettling, while severe anxiety can be extremely debilitating, having a serious ...Read more


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My doctor just upped my dosage on Zoloft (sertraline) today to 200mg (social anxiety)..It hasn't worked for 3 months, so if this doesn't work, what should I try?

My doctor just upped my dosage on Zoloft (sertraline)  today to 200mg (social anxiety)..It hasn't worked for 3 months, so if this doesn't work, what should I try?

Social anxiety: Different people respond differently to same medication. If not already doing so, cognitive behavior therapy in conjunction with medications is most helpful for your anxiety. Your prescribing doc. Can discuss with you the alternative medications, from supplementing to substituting to augmenting to switching, etc. ...Read more

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I am diagnosed with severe OCD. Doc put me on Zoloft (sertraline) 300mg QD and Anafranil 75mg OD. My question is that, this is a normal dosage to tackle anxiety???

I am diagnosed with severe OCD. Doc put me on Zoloft (sertraline) 300mg QD and Anafranil 75mg OD. My question is that, this is a normal dosage to tackle anxiety???

OCD: Use of higher doses of anti-depressants such as zoloft (sertraline) is effective for OCD. The Anafranil dose if moderate but could cause an interaction with the very high dose of zoloft (sertraline). Contact your doctor if you experience any side effects chills, diarrhea, muscle pain, excessive sweating, agitation. ...Read more

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After stopping Cymbalta (duloxetine) 60mg my dr gave me 25mg zoloft for anxiety/ocd. Says it will not cause weight gain at this dosage. I gained on cymbalta (duloxetine)..?tx

After stopping Cymbalta (duloxetine) 60mg my dr gave me 25mg zoloft for anxiety/ocd.  Says it will not cause weight gain at this dosage.  I gained on cymbalta (duloxetine)..?tx

Weight Gain: I hope this works for you. Time will tell. I find my patients seem to eventually gain weight on these medications regardless of the dose. Wellbutrin (bupropion) is the only antidepressant that seems not to contribute to weight gain. However, this medication might be appropriate for you. I hope you will not be offended by my suggestion: Perhaps this could be a good time to increase your activity level. ...Read more

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Doing pretty well with Zoloft; just upped from 100 to 150mg; feeling a bit anxious &jittery; normal for a dose increase? Taking for anxiety

Doing pretty well with Zoloft; just upped from 100 to 150mg; feeling a bit anxious &jittery; normal for a dose increase? Taking for anxiety

Sertraline: can sometimes work wonders for anxiety, I am glad you are having some success with it. It is normal practice to increase doses of this medicine by 25-50mg. ...Read more

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Taking Zoloft (sertraline) @ night for 11 days. Wake up very anxious. Okay to skip dose tonight? Have exam in morning & want to avoid anxiety. Will take later.

Taking Zoloft (sertraline) @ night for 11 days. Wake up very anxious.  Okay to skip dose tonight? Have exam in morning & want to avoid anxiety. Will take later.

Half-life = 1 day: Especially if you think it will help, you should be okay. But don't make it a practice. Do discuss options w/ your Dr - that's a rough side effect! Please consider CBT as an addition or alternative - research is clear on this for optimal help. You'll still have half in you so don't take an extra dose, just wait till evening. Best! ...Read more

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I have anxiety.My Zoloft (sertraline) dose was raised from 50(was fine for 2 years)to100(fine for 6mos and now 150 anxiety back.Have you seen this amount effective?

I have anxiety.My Zoloft (sertraline) dose was raised from 50(was fine for 2 years)to100(fine for 6mos and now 150 anxiety back.Have you seen this amount effective?

Yes: Doses of antidepressants like zoloft (sertraline) needed for symptom control can vary from person to person, and from time to time in their lives. If your prescribing doctor isn't a psychiatrist, it might be time to consult one. Also, working in psychotherapy can help you discover what drives your anxiety, and learn how to modulate it. The book "the mindful way through anxiety" can be very helpful too. ...Read more

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How long does it take for higher dose of Zoloft to kick in? Went from 75 to 100 bc of bad anxiety. Been taking Xanax for 3 weeks now and want to stop.

How long does it take for higher dose of Zoloft to kick in? Went from 75 to 100 bc of bad anxiety. Been taking Xanax for 3 weeks now and want to stop.

Within a few days: Zoloft (sertraline) has a half-life of 26 hours, so the dosage adjustment will "kick in" in a few days at most. You don't mention your dosage of Xanax (alprazolam) but if you want to stop this drug, talk with your doctor about tapering the dose. Both Xanax and Zoloft have warnings about sudden discontinuance -- can trigger withdrawal symptoms that are unpleasant. Consider CBT therapy for anxiety ...Read more

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I have been on 100mg Zoloft (sertraline) for a month for anxiety. I don't think i feel better and i might even be depressed? Do i need to increase the dose?

I have been on 100mg Zoloft (sertraline) for a month for anxiety.  I don't think i feel better and i might even be depressed?  Do i need to increase the dose?

Talk w/your doctor: Are you working with a psychiatrist who prescribed the zoloft (sertraline)? It and other antidepressants require at least 4-6 weeks' trial for effectiveness. You may need a higher dose, but you need to discuss this with your own doctor who knows you much better than we on healthtap do. Please also avoid the alcohol since it can dysregulate your sleep and mood. ...Read more

Dr. Donald Jacobson
1,041 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


Dr. Alan Ali
993 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more