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Doctor insights on: Zoloft Does Not Cause Weight Gain

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Does Zoloft (sertraline) cause weight gain? What is the best time of day to take it?

Does Zoloft (sertraline) cause weight gain? What is the best time of day to take it?

Yes sometimes: All of the serotonin enhancing antidepressants can cause weight gain, some more than others. Zoloft (sertraline) tends to be middle of the road where it may or may not. In my experience, it's not particularly weight gaining. As for time of day, what determine this is the effect it has on you. You can start out taking it in the morning and if it makes you sleepy/tired, switch it to night. ...Read more

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Dr. Michael Rothman
1,333 doctors shared insights

Weight Gain (Definition)

Weight gain is an increase in body weight. This can be a result of increases to muscle mass, increases in body fat, or increases in body fluids like water. Occasionally, weight gain can be a symptom of ...Read more


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Does Zoloft (sertraline) cause weight gain? Are there any interactions with Zoloft (sertraline) and st. John's wort?

Does Zoloft (sertraline) cause weight gain?   Are there any interactions with Zoloft (sertraline) and st. John's wort?

Probaly Not: There is no strong association between zoloft (sertraline) and weight gain but depression can cause loss of appetite and treatment may cause it to return. Do not take st. Johns wort, its affects are additive to zoloft (sertraline) and might cause a condition called serotonin syndrome or neuroleptic malignant syndrome. ...Read more

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After stopping Cymbalta (duloxetine) 60mg my dr gave me 25mg zoloft for anxiety/ocd. Says it will not cause weight gain at this dosage. I gained on cymbalta (duloxetine)..?tx

After stopping Cymbalta (duloxetine) 60mg my dr gave me 25mg zoloft for anxiety/ocd.  Says it will not cause weight gain at this dosage.  I gained on cymbalta (duloxetine)..?tx

Weight Gain: I hope this works for you. Time will tell. I find my patients seem to eventually gain weight on these medications regardless of the dose. Wellbutrin (bupropion) is the only antidepressant that seems not to contribute to weight gain. However, this medication might be appropriate for you. I hope you will not be offended by my suggestion: Perhaps this could be a good time to increase your activity level. ...Read more

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Can going off Zoloft (sertraline) cause weight gain/bloating? How do you rectify that without going back on zoloft (sertraline)?

Can going off Zoloft (sertraline) cause weight gain/bloating?  How do you rectify that without going back on zoloft (sertraline)?

Not usually: Weight gain or boating isn't usually a result of gradually stopping zoloft (sertraline) - bloating can actually improve on zoloft (sertraline). However, in some folks, there are flu-like symptoms that arise from the first couple of weeks of being on zoloft (sertraline). See below for more info. http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0001017/. ...Read more

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What causes weight gain using Zoloft? If you eat the same & exercise, why do people gain on it? What mechanism is involved? Does metabolism change?

What causes weight gain using Zoloft?  If you eat the same & exercise, why do people gain on it?  What mechanism is involved?  Does metabolism change?

Appetite increase: A number of psychiatric drugs, including most SSRIs (with the exception usually of fluoxetine or Prozac) cause an increase in appetite. I am not aware of evidence that they lower metabolic rate. Increasing physical activity and being more careful with eating, particularly craving-driven eating, generally helps. Drinking more water gives you a full sensation in your stomach; also carrots & celery ...Read more

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Does Zoloft or Abilify (aripiprazole) typically cause weight gain? I'm worried my extra few lbs are from the meds. 150mg Zoloft and 8 mg Abilify (aripiprazole)

Does Zoloft or Abilify (aripiprazole) typically cause weight gain? I'm worried my extra few lbs are  from the meds. 150mg Zoloft and 8 mg Abilify (aripiprazole)

Weight gain on meds: There can be weight gain which is due to a variety of factors: slowed metabolism and increased hunger (esp from abilify) keep track of your weight and exercise. Its easier to avoid wt gain if you pay attention than it is to lose later. Depression is not a good way to lose wt. ...Read more

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Can going off Zoloft (sertraline) cause weight gain/bloating? Will this side effect go away the longer your off?

Can going off Zoloft (sertraline) cause weight gain/bloating?  Will this side effect go away the longer your off?

Not really : Zoloft (sertraline) is anti depressant and anti anxiety medication , usually among his side effect ; sexual side effect , upset stomach and can cause weight gain . U may have stopped it suddenly and u r experiencing withdral symptoms ...Read more

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I read that antidepressants cause weight gain due to insulin resistance. If I take zoloft, (sertraline) I can counter weight gain taking L-glutamine and L-leucine?

I read that antidepressants cause weight gain due to insulin resistance. If I take zoloft, (sertraline) I can counter weight gain taking L-glutamine and L-leucine?

Chromium pic: Chromium picconalate helps regulate glucose and Insulin very effectively. SSRIs and related meds affect serotonin in the gut and other areas besides the brain. The GI tract has lots of serotonin receptors. The mechanism of meds affecting blood sugar isn't fully clarified. ...Read more

Dr. Donald Jacobson
1,041 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


Dr. Alan Ali
993 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more