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Doctor insights on: Zoloft Bad For Your Liver

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Is Zoloft (sertraline) bad for my liver?

Is Zoloft (sertraline) bad for my liver?

Probably Not: Although metabolized by the liver, zoloft (sertraline) is one of the milder antidepressants on the liver. If you are very concerned you can ask your doc to check your liver enzymes. ...Read more

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Dr. James Chapman
2 doctors shared insights

Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


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Im 16 male and have overdosed 3 times on zoloft (sertraline). Im getting scared that my life may be in danger due to liver damage. Pleas help?

Im 16 male and have overdosed 3 times on zoloft (sertraline). Im getting scared that my life may be in danger due to liver damage. Pleas help?

Major Depression: I understand your distress. It seems that stresses have made you very depressed and hopeless. You were born with the Blessing and Wonder of Life Force and Breath of Life due to which you are alive today. Liver damage is not a common side effect of Zoloft (sertraline). See GI Specialist for liver status. See Psychiatrist for Diagnosis; discuss Inpatient Psychiatric Treatment You are a precious Human Being! ...Read more

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Im taking Zoloft (sertraline) 75, can it cause liver enzymes higher?

Im taking Zoloft (sertraline) 75, can it cause liver enzymes higher?

Transaminases: can go up a bit. If your bilirubin is up or your albumen drops you need to discuss this with your doctor. ...Read more

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Hi, My boyfriend has a fatty liver and his doctor has prescribed him sertraline (zoloft) for anxiety how big of a risk will this affect his liver?

Hi, My boyfriend has a fatty liver and his doctor has prescribed him sertraline (zoloft) for anxiety how big of a risk will this affect his liver?

Minimal probable: Depending on the severity of your BF's liver disease, the medication Sertraline should be ok, but his Liver function tests should be monitored periodically as a precaution. Best wishes. ...Read more

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I'm taking Zoloft (sertraline) 200, lamictal 200 and olanzapine 10 for the last 2 years, it was lower before that, can it cause liver damage, or other dangerous things?

I'm taking Zoloft (sertraline) 200, lamictal 200 and olanzapine 10 for the last 2 years, it was lower before that, can it cause liver damage, or other dangerous things?

No: If you are taking your meds as prescribed, ; your liver is functioning normally, it should be O.K. If you are started on Depakote or depakene, (valproic acid) you may need to have the Lamictal reduced or started on those meds at a very low dose, as it can cause Lamictal levels to be increased by 50% in your system. ...Read more

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I have 3 prescriptions. Zoloft, Nexium (esomeprazole) and clonazepam. Are any of these hard on or dangerous to your liver?

I have 3 prescriptions.  Zoloft, Nexium (esomeprazole) and clonazepam.  Are any of these hard on or dangerous to your liver?

All three of these: medications are broken down by your liver. If your liver is normal it should not be dangerous. ...Read more

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Is it ok to take seroquel xr, Zoloft (sertraline) and liver tone plus tablet at night so you would not get that hangover filling in the morning.

Is it ok to take seroquel xr, Zoloft (sertraline) and liver tone plus tablet at night so you would not get that hangover filling in the morning.

Hangover?: If having a hangover feeling after taking your prescribed medications at night, your dose may need adjusting -- especially the seroquel (quetiapine). I suggest discussing what you're experiencing with your doctor, since s/he may be able to help you solve the problem without additional supplements. Livatone plus has milk thistle in it -- and studies of interactions w/medications are equivocal. ...Read more

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Looking for a safe combo, antipsychotic with 100 mg Zoloft (sertraline) daily - slightly sensitive liver cannot take lithium or Depakote (dizziness, low bp)?

Looking for a safe combo, antipsychotic with 100 mg Zoloft (sertraline) daily - slightly sensitive liver cannot take lithium or Depakote (dizziness, low bp)?

Abilify (aripiprazole) both: Augments the antidepressant effect of zoloft and treats the psychosis. I would start there. Dose will need to be slightly lowered because zoloft can raise Abilify (aripiprazole) levels. I also find that it has very good results in ptsd. My Next Choice would be seroquel. Discuss dosing with your psychiatrist and make sure you are definitely not bipolar. ...Read more

Dr. Donald Jacobson
1,039 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


Dr. Alan Ali
991 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more