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Doctor insights on: Zoloft And Zyprexa

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What can happen if you take Zoloft (sertraline) with zyprexa?

What can happen if you take Zoloft (sertraline) with zyprexa?

Zoloft/Zyprexa: Fairly common combination for major depression with psychotic features. ...Read more

Dr. Heidi Fowler
1,087 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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My doc me advised Zoloft (sertraline) 100mg & Zyprexa 5mg. My problem is that with Zyprexa I can't even wake up in mornings & go work. Any advise that save my job?

My doc me advised Zoloft (sertraline) 100mg & Zyprexa 5mg. My problem is that with Zyprexa I can't even wake up in mornings & go work. Any advise that save my job?

There are plenty: There are plenty alternatives to both Zoloft (sertraline) and zyprexa in their own classes on medications. Depending from causes of your depression social anxiety old treatment could be directed to non psychotropic route as well. You might need to ask your doc directly for it. Thanks. ...Read more

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I'm on clomipramine, Zoloft (sertraline) and zyprexa. My mood is pretty well now but gaining weight v rapidly. Shall I take metformin to control obesity? Advice pl

I'm on clomipramine, Zoloft (sertraline) and zyprexa. My mood is pretty well now but gaining weight v rapidly. Shall I take metformin to control obesity? Advice pl

Yes: Metformin is definitely indicated in this circumstance. Low dose topiramate or Diethylpropion can also help if needed. Watching your total caloric intake and especially carbohydrate intake will be important. Work with a dietician if necessary. Exercise as recommended by your physician is also very important. Best wishes. ...Read more

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My pdoc advised me zoloft, (sertraline) anafranil and zyprexa. My weight increasing very rapidly. Shall I take glucophage for weight loss without prescription?

My pdoc advised me zoloft, (sertraline) anafranil and zyprexa. My weight increasing very rapidly. Shall I take glucophage for weight loss without prescription?

No: The first thing is to look into healthy diet and exercise routine. Although, the above medications can cause increase in appetite, you should be able to change your diet to eat healthier to minimize their adverse effects. Also, you should work with your doctor and see if there are less aggressive weight gainer alternatives that can be used instead of some of those meds (abilify (aripiprazole) vs. Zyprexa). ...Read more

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I have really bad depression, pts, and I have bipolar. I'm on endep 50mg twice a day Zoloft (sertraline) 100mg twice a day n zyprexa 10ml once daily, is it lifetime?

I have really bad depression, pts, and I have bipolar. I'm on endep 50mg twice a day Zoloft (sertraline) 100mg twice a day n zyprexa 10ml once daily, is it lifetime?

Bipolar Disorder: Will likely require life-long medication. However, that doesn't necessarily mean that you will always need the same medication regiment. Take care. ...Read more

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I'm on Buspar (buspirone) zyprexa and Zoloft an I I've been taking a lot of cough syrup with dxm I think I have seratobin syndrome really bad taste tingling face?

I'm on Buspar (buspirone) zyprexa and Zoloft an I I've been taking a lot of cough syrup with dxm I think I have seratobin syndrome really bad taste tingling face?

Not likely: Full-blown serotonin syndrome is a medical emergency, and can include loss of consciousness and seizures. Sounds like the cough syrup with dxm is being abused, and your doctors, who are trying to treat anxiety and depression, are flying "blind" if they don't know about your drug use. Be honest with yourself and with them, and let them know what is going on. Stop the cough syrup, talk to your docs. ...Read more

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This 4 medicines were prescribed to my son with squizofrenia:haloperidol, benztrapine, sertraline and zyprexa (olanzapine). Are they ok the together?

This 4 medicines were prescribed to my son with squizofrenia:haloperidol, benztrapine, sertraline and zyprexa (olanzapine). Are they ok the together?

Interactions always: The combination of 3 or more medications (especially any which are considered to be active within the brain) is almost always going to result in risk in some side effect that people may not like. However, your doctor should already considered this fact and decided that the benefits outweigh the risks. Nonetheless, speaking to either the pharmacist or physician before starting the plan can't hurt. ...Read more

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Do drugs like Zoloft (sertraline) and olanzapine work on the parasympathetic nervous system and that's what calms you down?

No.: The parasympathetic nervous system does not "calm you down." These drugs work at the cortical and subcortical levels. Any affective influences of the autonomic nervous system are secondary to the physiological effects. ...Read more

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I'm taking Zoloft (sertraline) 200, lamictal 200 and olanzapine 10 for the last 2 years, it was lower before that, can it cause liver damage, or other dangerous things?

I'm taking Zoloft (sertraline) 200, lamictal 200 and olanzapine 10 for the last 2 years, it was lower before that, can it cause liver damage, or other dangerous things?

No: If you are taking your meds as prescribed, ; your liver is functioning normally, it should be O.K. If you are started on Depakote or depakene, (valproic acid) you may need to have the Lamictal reduced or started on those meds at a very low dose, as it can cause Lamictal levels to be increased by 50% in your system. ...Read more

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Can Olanzapine make burning skin pain worse aswell as Zoloft (sertraline)?

Can Olanzapine make burning skin pain worse aswell as Zoloft (sertraline)?

Yes: This is actually a reported side effect. Dermatologic side effects frequently include ecchymosis, sweating, acne, and dry skin. Alopecia, contact dermatitis, eczema, maculopapular rash, pruritus, seborrhea, skin discoloration, skin ulcer, urticaria, and vesiculobullous rash have also been reported. It also is risky w/ Tramadol and/or Valium. Your needs are complex. Work closely w/ your Dr (s). ...Read more

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Do the drugs olanzapine, Zoloft (sertraline) and elavil work on the parasympathetic nervous system to calm you down?

Do the drugs olanzapine, Zoloft (sertraline) and elavil work on the parasympathetic nervous system to calm you down?

Elavil (amitriptyline): Has mostly anticholinergic side effects (dry mouth, constipation, elevated heart rate) just the opposite of parasympathetic. The calming effect is due to a much more complex interaction of excitatory and inhibitory neurotransmitters further up stream (cortex and deep gray matter structures like the thalamus, the hypopithalamus, putamen, globus pallidus, nucleus accumbens, ventral tegmental area.) ...Read more

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I take 200 mg zoloft, (sertraline) 200 mg lamictal and 10 mg olanzapine since 4 years. Can it cause a permanent impotence and problems with erection for ever, even after stopping it. Am I in danger? What should I do

I take 200 mg zoloft, (sertraline) 200 mg lamictal and 10 mg olanzapine since 4 years. Can it cause a permanent impotence and problems with erection for ever, even after stopping it. Am I in danger? What should I do

See comment: All these medication contribute to impotence
the main question is : what is your basic condition that requires taking these drugs?
Usually after stopping the drugs condition may improve, but don't stop any without your doctors advice. ...Read more

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I'm on 100mgs of Zoloft, (sertraline) and 50 of trazodone. My boyfriend takes Prozac and olanzapine and sleeps like a rock. Can I have my doctor sub traz for olanz?

I'm on 100mgs of Zoloft, (sertraline) and 50 of trazodone. My boyfriend takes Prozac and olanzapine and sleeps like a rock. Can I have my doctor sub traz for olanz?

Polypharmacy risks: Risk vs benefit. Everything you do in life has its risks and its benefits. The drug that your be is on has a lot of potentially serious side effects including an increased risk of suicide in teens and young adults. It can also cause significant weight gain. It can cause a lot of other things too. There are better ways to induce sleep. Good luck. ...Read more

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Is it safe taking sertraline with olanzapine? Sertraline for OCD and olanzapine for sleep.?

Is it safe taking sertraline with olanzapine? Sertraline for OCD and olanzapine for sleep.?

Safe to take: Yes, you can safely take these drugs together. If you are on higher doses of them, taking both can make you more prone to side effects like drowsiness, but if taking olanzapine for sleep I suspect you are on low dose. ...Read more

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Psychiatrist put me on olanzapine 5mg tablets. Side effects mention "sudden unexplained death". Doc says still to take. On sertraline 200mg. Any advice?

Depends on response: Many patients do take olanzepine for mental illness. Patients on olanzepine need to be monitored for metabolic syndrome as well for abnormal movements. Report any adverse effect immediately to your. Doctor. ...Read more

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Was takin olanzapine and got muscle spasms everywhere! They said it was anxiety? Come off olanzapine now they said try sertraline would it stop spasms

Was takin olanzapine and got muscle spasms everywhere! They said it was anxiety? Come off olanzapine now they said try sertraline would it stop spasms

Probably not: It is unclear what was causing the muscle spasms and it sounds like they didn't stop when you stopped the olanzapine.
Sertraline is not prescribed for muscle spasms.
I would recommend that you see you internist and try to understand the cause of the spasms. ...Read more

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Was taking olanzapine and they give me muscle spasms everywhere! They said it wasn't that what caused it! Could sertraline get rid of muscle spasms?

Not likely: Olanzapine muscle spasms are often due to the effects of Olanzapine on dopamine. Sertraline would not help this problem. You should talk to your doctor, first because you want someone to assess the kind of muscle spasm you were having, and second so that your doctor can suggest the appropriate thing to do. ...Read more

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What is zyprexa (olanzapine) used for 10mg?

What is zyprexa (olanzapine) used for 10mg?

Several things: Approved uses our schizophrenia and bipolar disorder. Off label uses are for the stabilization of certain types of personality disorders, intermittent explosive disorder, and sometimes as an appetite stimulant in severe forms of anorexia nervosa. It can occasionally be prescribed for autistic spectrum disorders and an augmentation strategy for intractable depressive disorders when all else has failed. Hope this helps. Best wishes. ...Read more

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Can zyprexa (olanzapine) cause irritability?

Can zyprexa (olanzapine) cause irritability?

Yes: Zyprexa (olanzapine) may cause restlessness (akathisia), involuntary movements (tardive dyskinesia and irritability in addition to that it may cause fatigue, apnea, dry mouth, red eye, mydriasis, dizziness, sedation, insomnia, constipation, urinary retention, orthostatic hypotension, heart failure, heart attack, or stroke, weight gain and increased appetite. ...Read more

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Why is 20 mgs of zyprexa doing nothing for my paranoia?

Why is 20 mgs of zyprexa doing nothing for my paranoia?

Uncertain: However, we don't know if this is paranoia that is part of your normal personality, a paranoid delusion or a symptom of a thought disorder (like schizophrenia). Each may respond quite differently. Hopefully you are also receiving psychotherapy. Take care. ...Read more

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Why does zyprexa (olanzapine) withdrawal cause insomnia?

Why does zyprexa (olanzapine) withdrawal cause insomnia?

It's very sedating.: Zyprexa (olanzapine) is notorious for being extremely sedating so it's unlikely a true withdrawal but more a readjustment to not taking such a powerful hypnotic. ...Read more

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Can I take zyprexa (olanzapine) with garcinia cambogia?

Can I take zyprexa (olanzapine) with garcinia cambogia?

Zyprexa (olanzapine): Zyprexa (olanzapine) can can treat a number of emotional issues.
Garcinia cambogia can be helpful for weight loss but don't overdo it. ...Read more

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Is zyprexa (olanzapine) (olanazipine) safe during pregnancy pls?

Is zyprexa (olanzapine) (olanazipine) safe during pregnancy pls?

Possibly: Please discuss the benefits of using this medication vs risks of illness in pregnancy without it, with your psychiatrist and OB doctor. However, a prospective study with this & other atypical antipsychotics vs controls without such exposures, showed no differences between groups in terms of risk for fetal malformations or rates of obstetrical or neonatal complications. Larger studies needed. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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Could I start losing weight if I switch zyprexa to abilify (aripiprazole)?

Dr. Alan Ali Dr. Ali
1 doctor agreed:

Zyprexa (olanzapine): Zyprexa causes noticeable weight gain, less likely with abilify (aripiprazole). ...Read more

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Craving carb and sugar on 5 mg zyprexa. Do you always gain weight on this medicine if you exercise and eat healthier?

Craving carb and sugar on 5 mg zyprexa. Do you always gain weight on this medicine if you exercise and eat healthier?

Weight gain is very: Common but does not happen to everyone taking Zyprexa. However lifestyle measures including exercise, sleep and dietary adjustments can reduce the amount of weight gain or even eliminate it in many individuals. If weight gain is problematic despite these measures then the prescriber may find an alternative medication with less risk. Best regards for good health. ...Read more

Olanzapine (Definition)

Also called zyprexa, (olanzapine) is a second generation antipsychotic that works to alleviate symptoms of ...Read more


Dr. Alan Ali
251 Doctors shared insights

Zyprexa (Definition)

Zyprexa is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more