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Doctor insights on: Zoloft And Orgasms

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Just started Zoloft (sertraline) & wow, orgasms are impossible! Sucks. Anything I can do (take) to fix? Besides switching-enough side effects already.

Just started Zoloft (sertraline) & wow, orgasms are  impossible! Sucks. Anything I can do (take) to fix? Besides switching-enough side effects already.

Switch.: The SSRI group can cause sexual dysfunction for some individuals, both male and female., When it occurs there are three alternatives. First, switch to a different SSRI. Second, reduce the dose and add Wellburtrin. Third, switch to Wellburtrin. ...Read more

Orgasm (Definition)

Conventionally, orgasm is the culmination of sexual arousal (and may be repeated) and typically produces great pleasure through direct genital stimulation of the male penis and female clitoris. However, orgasm may also be achieved via the brain or as a reflex arc. The physical characteristics are an explosive peak & repeated neuromuscular action causing release of male ...Read more


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Can Wellbutrin (bupropion) be taken simultaneously with Zoloft to eliminate difficulty orgasming side effect?

Can Wellbutrin (bupropion) be taken simultaneously with Zoloft to eliminate difficulty orgasming side effect?

Yes: Zoloft (sertraline) can have an unfortunate side effect of anorgasmia. It is really unacceptable, but if Zoloft (sertraline) is helping, it is hard to give it up. It is a common practice among psychiatrists to prescribe a medicine to counteract that side effect, and buproprion is often a first choice. It is a safe combination, although the dose may have to be optimized. Experience says it often works. Good luck! ...Read more

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I'm on Zoloft (sertraline) and vistaril can that cause women not to orgasm?

I'm on Zoloft (sertraline) and vistaril can that cause women not to orgasm?

Possibly: Zoloft (sertraline) and others in its class (ssri antidepressants) can interfere with sexual functioning, including delayed orgasm. I have known some for whom orgasm became impossible with these medicines, and it may be a dose-related effect. Talk with your doctor about it; there are ways to adjust things or add other medicines that may be able to normalize this. ...Read more

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I am 28 yrs old I have been married for 7 years have to kids and have never orgasmed, I am taking zoloft! wham can I take to help me climax, help!

I am 28 yrs old I have been married for 7 years have to kids and have never orgasmed, I am taking zoloft! wham can I take to help me climax, help!

Several roads: Yes, zoloft, (sertraline) an ssri may causeyour problem. Check with your physician to see if you can use bupropion [wellbutrin]. If this change does not correct the issue then you ask for a referral to a sexual dysfunction group. . My bias would be for you to call loyola medical center, in chicago and ask for dr renshaw's clinic. See if they have someone in your area who has trained with her. ...Read more

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Celexa causes hard to reach orgasm. Would lowering the dose help and can it become permanent? Im on 20 mg. It does help me though. Zoloft (sertraline) made me sick

Celexa causes hard to reach orgasm. Would lowering the dose help and can it become permanent? Im on 20 mg. It does help me though. Zoloft (sertraline) made me sick

Almost immedicately: The side effect is dose related and improves as soon as the blood levels drop which could be the next day. Of course over time if the depression returns your libido could plummet. Lexapro (escitalopram) may have less sexual dysfunction than Celexa. Young men who are anorgasmic on low doses of SSRI, I wonder about Bipolar disorder and would consider Lamictal as alternate rx ...Read more

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My 33 y/o wife of 9 years has never had an orgasm from sex or toys/self.Her obgyn says she is ok physically.Psych says maybe anxiety - she has taken Zoloft (sertraline) for this in the past. What can we do?

My 33 y/o wife of 9 years has never had an orgasm from sex or toys/self.Her obgyn says she is ok physically.Psych says maybe anxiety - she has taken Zoloft (sertraline) for this in the past. What can we do?

Sexual fears: Many women have histories of rape or childhood abuse. I don't know whether this is the case with your wife, but if so, zoloft (sertraline) will not cure it. For some such women, sexual activity is so frightening that they can't explore/enjoy their own bodies' responses. If your wife regards your listed concerns as a problem, she could consult with a sensitive therapist. Healing will be a gradual process. ...Read more

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Dr. Heidi Fowler
1,067 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


Dr. Alan Ali
1,021 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more