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Doctor insights on: Zoloft And Amitriptyline

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Is tramacet with Zoloft (sertraline) 50mg and amitriptyline 10 mg ok in combination ?

Is tramacet with Zoloft (sertraline) 50mg and amitriptyline 10 mg ok in combination ?

In most people: It depends on the individual. All of that serotonin can put a patient with bipolar disease at risk of a manic episode. If it hasn't happened, it wont. Excess serotonin can cause rapid heart rate, anxiety and shakiness. I personally try to avoid using multiple drugs that work the same, since it can lead to toxic side effects. I like using drugs like abilify (aripiprazole) if I am treating mood disorder ...Read more

Dr. Donald Jacobson
1,041 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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Can you tell me what to do if i stopped taking 200 mg of Zoloft (sertraline) i'm now on amitriptyline 50mg . Will i get a bad withdrawal ?

Can you tell me what to do if i stopped taking 200 mg of Zoloft (sertraline) i'm now on amitriptyline 50mg . Will i get a bad withdrawal ?

Hard to say: Amitriptilyn is fairly anticholinergic. It might give you a dry mouth, elevated heart rate, blurred vision when reading especially with a dose large enough to replace the 200 mg of zoloft (sertraline). Discuss this with your doctor. ...Read more

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Why would I of been prescribed Zoloft (sertraline) if serotonin makes skin burning worse ? Would amitriptyline help instead ?

Why would I of been prescribed Zoloft (sertraline) if serotonin makes skin burning worse ? Would amitriptyline help instead ?

They didn't know: Amitriptyline also has a long, long list of possible side effects. Not everyone suffers them, certainly not all of them but they are possible. Same w/ your Zoloft (sertraline). It's trial and error and none are 100% free of bad side effects. If you cam minimize use - good! CBT therapy can help you do that. Don't try to self- Rx - it takes training and you're sensitive on top of that. ...Read more

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Is a combination of meds like tramadol, amitriptyline and Zoloft (sertraline) better for controlling nerve pain than one of the meds alone ?

Is a combination of meds like tramadol, amitriptyline and Zoloft (sertraline) better for controlling nerve pain than one of the meds alone ?

Depends: Presumably you're working with a neurologist or pain management specialist for neuropathic pain treatment. If not, you should see one. It is always better to treat a condition with the least number of medications and the lowest dose of each medication possible. Discuss this with your physician. http://www.webmd.com/pain-management/guide/neuropathic-pain ...Read more

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I am worried about the interaction of Zoloft (sertraline) and elavil , the drowsiness does not bother me as a matter of fact better rest is welcome.

One too many: Taking two serotonergic drugs with similar mechanism of action is generally not advisable. Serotonin syndrome which can be seriously life threatening may occur. Talk with you doctor about getting on one serotonin drug. ...Read more

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Do the drugs olanzapine, Zoloft (sertraline) and elavil work on the parasympathetic nervous system to calm you down ?

Do the drugs olanzapine, Zoloft (sertraline) and elavil work on the parasympathetic nervous system to calm you down ?

Elavil (amitriptyline): has mostly anticholinergic side effects (dry mouth, constipation, elevated heart rate) just the opposite of parasympathetic. The calming effect is due to a much more complex interaction of excitatory and inhibitory neurotransmitters further up stream (cortex and deep gray matter structures like the thalamus, the hypopithalamus, putamen, globus pallidus, nucleus accumbens, ventral tegmental area.) ...Read more

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I have really bad depression, pts, and I have bipolar. Im on endep 50mg twice a day Zoloft (sertraline) 100mg twice a day n zyprexa 10ml once daily, is it lifetime?

I have really bad depression, pts, and I have bipolar. Im on endep 50mg twice a day Zoloft (sertraline) 100mg twice a day n zyprexa 10ml once daily, is it lifetime?

Bipolar Disorder: Will likely require life-long medication. However, that doesn't necessarily mean that you will always need the same medication regiment. Take care. ...Read more

Dr. Robert Kent
363 doctors shared insights

Elavil (Definition)

Elavil is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more


Dr. Heidi Fowler
306 doctors shared insights

Endep (Definition)

Endep is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more