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Doctor insights on: Zoloft And Amitriptyline

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Is tramacet with Zoloft (sertraline) 50mg and amitriptyline 10 mg ok in combination?

Is tramacet with Zoloft (sertraline) 50mg and amitriptyline 10 mg ok in combination?

In most people: It depends on the individual. All of that serotonin can put a patient with bipolar disease at risk of a manic episode. If it hasn't happened, it wont. Excess serotonin can cause rapid heart rate, anxiety and shakiness. I personally try to avoid using multiple drugs that work the same, since it can lead to toxic side effects. I like using drugs like abilify (aripiprazole) if I am treating mood disorder ...Read more

Dr. Heidi Fowler
1,087 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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Can you tell me what to do if I stopped taking 200 mg of Zoloft (sertraline) I'm now on amitriptyline 50mg. Will I get a bad withdrawal?

Can you tell me what to do if I stopped taking 200 mg of Zoloft (sertraline) I'm now on amitriptyline 50mg. Will I get a bad withdrawal?

Hard to say: Amitriptilyn is fairly anticholinergic. It might give you a dry mouth, elevated heart rate, blurred vision when reading especially with a dose large enough to replace the 200 mg of zoloft (sertraline). Discuss this with your doctor. ...Read more

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Why would I of been prescribed Zoloft (sertraline) if serotonin makes skin burning worse? Would amitriptyline help instead?

Why would I of been prescribed Zoloft (sertraline) if serotonin makes skin burning worse? Would amitriptyline help instead?

They didn't know: Amitriptyline also has a long, long list of possible side effects. Not everyone suffers them, certainly not all of them but they are possible. Same w/ your Zoloft (sertraline). It's trial and error and none are 100% free of bad side effects. If you cam minimize use - good! CBT therapy can help you do that. Don't try to self- Rx - it takes training and you're sensitive on top of that. ...Read more

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Is a combination of meds like tramadol, amitriptyline and Zoloft (sertraline) better for controlling nerve pain than one of the meds alone?

Is a combination of meds like tramadol, amitriptyline and Zoloft (sertraline) better for controlling nerve pain than one of the meds alone?

Depends: Presumably you're working with a neurologist or pain management specialist for neuropathic pain treatment. If not, you should see one. It is always better to treat a condition with the least number of medications and the lowest dose of each medication possible. Discuss this with your physician. Http://www. Webmd. Com/pain-management/guide/neuropathic-pain ...Read more

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I am worried about the interaction of Zoloft (sertraline) and elavil, the drowsiness does not bother me as a matter of fact better rest is welcome.

One too many: Taking two serotonergic drugs with similar mechanism of action is generally not advisable. Serotonin syndrome which can be seriously life threatening may occur. Talk with you doctor about getting on one serotonin drug. ...Read more

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Do the drugs olanzapine, Zoloft (sertraline) and elavil work on the parasympathetic nervous system to calm you down?

Do the drugs olanzapine, Zoloft (sertraline) and elavil work on the parasympathetic nervous system to calm you down?

Elavil (amitriptyline): Has mostly anticholinergic side effects (dry mouth, constipation, elevated heart rate) just the opposite of parasympathetic. The calming effect is due to a much more complex interaction of excitatory and inhibitory neurotransmitters further up stream (cortex and deep gray matter structures like the thalamus, the hypopithalamus, putamen, globus pallidus, nucleus accumbens, ventral tegmental area.) ...Read more

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I have really bad depression, pts, and I have bipolar. I'm on endep 50mg twice a day Zoloft (sertraline) 100mg twice a day n zyprexa 10ml once daily, is it lifetime?

I have really bad depression, pts, and I have bipolar. I'm on endep 50mg twice a day Zoloft (sertraline) 100mg twice a day n zyprexa 10ml once daily, is it lifetime?

Bipolar Disorder: Will likely require life-long medication. However, that doesn't necessarily mean that you will always need the same medication regiment. Take care. ...Read more

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I was prescribed 10mg of Elavil for anxiety. Prozac (fluoxetine) gave me palpitations &Zoloft made me depressed. I'm so scared of side effects! Should I try this?

I was prescribed 10mg of Elavil for anxiety. Prozac (fluoxetine) gave me palpitations &Zoloft made me depressed. I'm so scared of side effects! Should I try this?

Medication effects: I understand you feeling scared of side effects of medication due to unpleasant experiences with 3 medications.
Discuss with Psychiatrist:
• Intensity of Symptoms at that time
• Diagnosis-Anxiety, Depression, or both
• Therapy for stresses of relationships, separations, school, work, and finances
• Develop Coping Skills
• Breathing Relaxation
• Visual Imagery
• Meditation
Yoga
Tai Chi ...Read more

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I was prescribed 10mg of Elavil for anxiety. Prozac gave me palpitations & Zoloft (sertraline) made me depressed. Should I try this? I'm so scared of side effects!

I was prescribed 10mg of Elavil for anxiety. Prozac gave me palpitations & Zoloft (sertraline) made me depressed. Should I try this? I'm so scared of side effects!

Agree with you: You have already had adverse effects from medications far less toxic than Elavil, (amitriptyline) which has substantial anti-cholinergic problems. Sounds like you may benefit from a second opinion regarding all of this. ...Read more

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Can I take amitriptyline with sertraline?

Caution: These medicines are both from the same drug family. Please talk with the doctor who is prescribing this medicine to you. As long as the medications are closely followed by the doctor, then the risk of having a bad drug-drug interaction will be very low.
Take care. .. ...Read more

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Anxiety bad switching 100 to 50mg of zoloft (sertraline). Amitriptiline 10mg substitute b/ headaches at 100mg of zoloft (sertraline). What is best balance = to 100 zoloft (sertraline).?

Anxiety bad switching 100 to 50mg of zoloft (sertraline). Amitriptiline 10mg substitute b/ headaches at 100mg of zoloft (sertraline). What is best balance = to 100 zoloft (sertraline).?

Be careful: This is a mix of a tricyclic antidepressant and a selective serotonin reputable inhibitor. The most important principle is very cautious introduction and very slow escalation in dose. The potential for qtc prolongation is elevated in this scenario and an ekg might be a precaution in dose adjustments. I would be surprised if you need more than 10 mg, 20 mg or 25 mg of amitriptyline. Talk to your md. ...Read more

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My girlfriend was prescribed sertraline and amitriptyline. I've heard mixing them isn't a good idea the risks outweigh the benefits. What do you think.

My girlfriend was prescribed sertraline and amitriptyline. I've heard mixing them isn't a good idea the risks outweigh the benefits. What do you think.

I have plenty of: Patients on the combination. The main risk is the zoloft (sertraline) driving up the blood level of the elavil, so I always check Elavil levels and use low doses. Serotonin syndrome is very rare in my experience. I've seen two cases in 30 years of practice. Best wishes. ...Read more

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My doctors have me on both sertraline (100mg) and amitriptyline (20 mg). Should I be worried about interactions like serotonin syndrome?

My doctors have me on both sertraline (100mg) and amitriptyline (20 mg). Should I be worried about interactions like serotonin syndrome?

I have had patients: On very low dose Amitriptyline with SSRI and none of them had any issues (knocking on wood); however, yes, I do always caution them about potential interactions and advise that they call me immediately should anything occur. ...Read more

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I want to know how many milligrams of amitriptyline equivalent to 75 of sertraline for the treatment of severe depression...

I want to know how many milligrams of amitriptyline equivalent to 75 of sertraline for the treatment of severe depression...

Not exactly what: You asked - but 98.5 of sertraline equivalent to 122.3 of amitrypline. I don't think that this is a useful equivalent now adays. The reason is that the dose of amitryptyline needed to tx depression would be high enough that side effects may not be tolerable.

https://www. Nationalelfservice. Net/treatment/antidepressants/dose-equivalents-antidepressants-standardising-prescribing-different-drugs ...Read more

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I am due to start amitriptyline and am really worried about weight gain. I was on sertraline and still on thyroxine, 100 mg?

I am due to start amitriptyline and am really worried about weight gain. I was on sertraline and still on thyroxine, 100 mg?

Weight gain may be: Associated with antidepressants like amitryptiline especially if your depression was associated with loss of appetite and weight. However, as long as you pay attention to your diet and keep your thyroid levels in the normal range, you should be fine. Go to www. Mayoclinic. Org ->patient care->health information
->healthy lifestyle-> nutrition and healthy eating for more info. Dr. Anne ...Read more

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Is Imipramine with Buspirone a good option to treat social anxiety & depression if sertraline, duloxetine, venlaflaxine, amitriptyline haven't helped?

Is Imipramine with Buspirone a good option to treat social anxiety & depression if sertraline, duloxetine, venlaflaxine, amitriptyline haven't helped?

Caution: Imipramine + buspirone may interact to increase risk for serotonin syndrome. Be sure you are closely supervised by prescribing doctor while taking these meds. Imipramine alone is effective for both depression and anxiety. See: http://www. Mayoclinic. Org/diseases-conditions/serotonin-syndrome/basics/definition/con-20028946 I hope this helps. Best wishes. ...Read more

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I am on 100mg sertraline and 30mg amitriptaline would it be harmful to have a glass of wine now and again?

I am on 100mg sertraline and 30mg amitriptaline would it be harmful to have a glass of wine now and again?

Unwise: You are taking sertraline, mirtazapine and amitriptyline which may already have significant interactions including sedation. The effects of alcohol as a central nervous system depressant are additive with all 3 meds and could prove serious. Make sure prescribing doctors know all meds you are taking. Be safe and avoid alcohol while on these meds. Take care. ...Read more

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Is it safe to take amitripyline 20mg, sertraline 100mg & piriton at the same time piriton& what effects could they cause?

Is it safe to take amitripyline 20mg, sertraline 100mg & piriton at the same time piriton& what effects could they cause?

Sedation: Piriton is an antihistamine that can be sedating -- making you sleepy. Combined with amitriptylene, even more so. If you're going to use them, i'd suggest spreading them out and not taking all at once -- unless you're planning to go to sleep. ...Read more

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On 100mg sertraline morning for anxiety 30mg amitriptaline night for nerve pain still having pain is it possible increase to 40mg or would be to much?

On 100mg sertraline morning for anxiety 30mg amitriptaline night for nerve pain still having pain is it possible increase to 40mg or would be to much?

Pain control: Frankly - would not change any of your medication doses without a discussion with your prescribing provider. Your physician may well elect to increase Elavil (amitriptyline) for pain. ...Read more

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Can amitriptaline or sertraline have an effect on your memory feel since being on them I seem to forget things more easily?

Can amitriptaline or sertraline have an effect on your memory feel since being on them I seem to forget things more easily?

These meds have: A long list of potential side effects, including memory or general cognitive problems. This is a question for your prescribing MD. ...Read more

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On 100mg sertraline morning for anxiety 30mg amitriptaline night for nerve pain bad time keeping asleep heard amitriptaline helps with sleep?

On 100mg sertraline morning for anxiety 30mg amitriptaline night for nerve pain bad time keeping asleep heard amitriptaline helps with sleep?

Talk to your doctor: Amitriptyline can be increased to see if this helps. However, this medication does have potential side effects such as drowsiness (which is what you want at night for sleep), dry mouth, constipation, urinary retention and decreased memory (especially in the elderly). Talk to your doctor about your specific treatment options. Hope this helps. Best wishes! ...Read more

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On 30mg amitriptaline at night for nerve pain and 100mg sertraline in the morning for anxiety/depression still in lots of pain what can I do?

On 30mg amitriptaline at night for nerve pain and 100mg sertraline in the morning for anxiety/depression still in lots of pain what can I do?

Please clarify: You mention you're in nerve pain and have anxiety/depression but you're still in "lots of pain." Do you mean physical, nerve pain or emotional pain or both? Please clarify, if possible, so I can better understand how to respond. Nerve pain or any physical pain that's chronic and unrelieved can also be contributing to your depression. ...Read more

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I am on sertraline 100 mg I have stopped taking the amitriptaline and mirtazapine could you recommend what I could take to help with sleep problems?

I am on sertraline 100 mg I have stopped taking the amitriptaline and mirtazapine could you recommend what I could take to help with sleep problems?

Work w/ your Dr: Ever a good idea to stop psych meds w/out professional guidance. Work together to find the right plan for you and add CBT theapy to optimize effects as well as learning skills to better life. This will include sleep skills! Best wishes. ...Read more

Dr. Jeffrey Satinover
379 Doctors shared insights

Elavil (Definition)

Elavil is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more


Dr. Heidi Fowler
327 Doctors shared insights

Endep (Definition)

Endep is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more