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Doctor insights on: Seronegative Osteoarthritis

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Dr. Qamar Khan
1,561 doctors shared insights

Osteoarthritis (Definition)

This common degenerative condition impacts the joints, where normal wear and tear on them gets to a point where they can no longer keep up with the pace of generating fresh cartilage. As a result, the joint space thins, the bone becomes exposed and painful, and bone spurs ...Read more


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Severe widespread joint pain/morning stiffness 9 mnth. Daily 20mg prednisone did not work, MRI of joints show no inflammation. RF DNA SM neg ANA 1:320?

Severe widespread joint pain/morning stiffness 9 mnth. Daily 20mg prednisone did not work, MRI of joints show no inflammation. RF DNA SM neg ANA 1:320?

Alternative: Despite ANA being positive, if you have no inflamm visible & prednisone had no effect, consider an alternative track: many foods cause sensitivities/joint/muscle pain without measurable inflammation.Sugar/Wheat/Gluten are among the most common.Consider seeing a doctor interested in 'Functional Medicine' & they can test for these sensitivities.Other thought: toxicities.These drs can test this, too. ...Read more

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Is positive anticardiolipin and positive antidsdna needed for lupus diagnosis? I have positive Ana, WBC 4.20 skin rashes, plus arthritis in joints

Is positive anticardiolipin and positive antidsdna needed for lupus diagnosis? I have  positive Ana, WBC 4.20 skin rashes, plus arthritis in joints

Rheumatologist: Anticardiolipin antibodies may not be present in many lupus cases but Ana and antidsdna findings are common. Your findings are consistent with lupus, but the rheumatologist is best qualified to evaluate and advise you about diagnosis and treatment. ...Read more

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What is seronegative RA? Is that Positive Rheumatoid Factor and negative Anti CCP?

What is seronegative RA?  Is that Positive Rheumatoid Factor and negative Anti CCP?

Seronegative RA: is when the rheumatoid factor is negative, one other common type of these are referred to as seronegative spondyloarthropathies or other seronegative disorders associted with inflammatory disease. there is a wide range ...Read more

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ANA 1:160 homogenous, anti ssDNA 42, normal Rh factor, ESR, anti dsDNA , neg HLA B27. Tests due to severe joint pain- is this indicative of lupus??

ANA 1:160 homogenous, anti ssDNA 42, normal Rh factor, ESR, anti dsDNA , neg HLA B27. Tests due to severe joint pain- is this indicative of lupus??

Might be.: These labs do not rule lupus out nor do they rule it in. I think your doc should keep looking and monitor your progress over time. Depending upon joints could represent parvovirus although that is just a wild guess. Your clinical picture and progress is most important. ...Read more

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I have joint pain and sometimes feel fever,twitching. Ana 1:40 but Rf, anti ccp , anti dna, anti sm,crp, Esr, scl-70 are negative, autoimmune disease?

I have joint pain and sometimes feel fever,twitching. Ana 1:40 but Rf, anti ccp , anti dna, anti sm,crp, Esr, scl-70 are negative, autoimmune disease?

Consultation advised: Unfortunately, Medicine is much too complicated to be able to give helpful advice on the basis of such limited information. An IN BOX Text consultation at Health Tap may be helpful.You would need to upload results of any tests, if available, as well as your medical history. You would NEED TO MAKE YOURSELF AVAILABLE for 24 hours to reply to any questions from your consultant.http://bit.ly/1OiIRcI ...Read more

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What is this means Anti CCP 319.8 ,CRP -,and RAfactor+ in rheumatoid Arthritis ?

What is this means Anti CCP 319.8 ,CRP -,and RAfactor+ in rheumatoid Arthritis ?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your test results are consistent with rheumatoid arthritis. ...Read more

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Aso titre positive 306 age 48 anticcp and RA factor negative.tell me the treatment?

Aso titre positive 306 age 48 anticcp and RA factor negative.tell me the treatment?

What symptoms?: If you are trying to diagnose arthritis causes, all this tells you is that RA is not a likely diagnosis, but your doctor needs to continue with the evaluation. Good luck and hope this clears up quickly. ...Read more

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Lower back pain for a month+stiffness in both hands. Ana 1:80 speckled+homogenous but very low crp, negative anticcp & lymphocytocis (55%). Arthritis?

Lower back pain for a month+stiffness in both hands. Ana 1:80 speckled+homogenous but very low crp, negative anticcp & lymphocytocis (55%). Arthritis?

See details: The lab results are unimpressive and the back pain would not be caused by any diseases related to these tests. The hand symptoms seem mild and vague. If you have concerns, see a rheumatologist but i see nothing in the lab that would alarm me. ...Read more

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Causes of elevated CRP (18.4) and C4 comlement (46)? History: ana, ccp positive. Sjogren's symptoms but ssa/b neg. No arthritis. Fatigued.?

Causes of elevated CRP (18.4) and C4 comlement (46)? History: ana, ccp positive. Sjogren's symptoms but ssa/b neg. No arthritis. Fatigued.?

You have inflammatio: Your tests indicate inflammation. Sjogren's not associated with high inflammation. Ccp positivity fairly specific for ra. Chronic fatigue is common in both RA and sjogrens. And sjogren's (2') common in ra! responds well to Nuvigil or provigil! have you seen a rheumatology specialist to sort things out? ...Read more

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I tested positive for the ANA screen, 1:160 titer, speckled pattern. Rheumatoid factor 21, SED rate 22. Does this indicate Rheumatoid arthritis?

I tested positive for the ANA screen, 1:160 titer, speckled pattern. Rheumatoid factor 21, SED rate 22. Does this indicate Rheumatoid arthritis?

No: The rheumatoid factor was barely above negative. It is usually greater than 150 in RA. The CCP antibody is a much more specific test. The diagnosis of RA depends on several diagnostic criteria. The rheumatoid factor is nonspecific. ...Read more

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Can anything other than myositis cause elevated jo 1 antibody? Possible false positive? Could I have been wrongly diagnosed w/ rheumatoid arthritis?

Can anything other than myositis cause elevated jo 1 antibody? Possible false positive? Could I have been wrongly diagnosed w/ rheumatoid arthritis?

Usually not RA.: Myositis can be associated with several types of autoantibodies: anti-jo1 antibodies are a type of anti-nuclear antibody. Anti-srp antibodies are mainly associated with, but are not specific for, polymyositis. The ccp antibody is most specific for ra. Keep in mind that certain meds for RA also work in myositis, such as Methotrexate and steroids. ...Read more