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Doctor insights on: Zanaflex Interactions

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I take Zanaflex (tizanidine) or flexeril (have both) and just started necon 10/11. I read there could be interactions with zanaflex (tizanidine). Do i need to be concerned?

I take Zanaflex (tizanidine)  or flexeril (have both) and just started necon 10/11. I read there could be interactions with zanaflex (tizanidine). Do i need to be concerned?

Yes, it is possible: Zanaflex (tizanidine) & Flexeril are muscle relaxants, while Necon 10/11 is an oral contraceptive.All the three medications are metabolized in the liver through cyp450. Necon is an inhibitor of 3a4 sub-enzyme, while Zanaflex (tizanidine) and Flexeril are not. Necon may increase the levels of Flexeril and zanaflex, (tizanidine) causing increased sedation, dizziness, impairment of fine motor movements, coordination and risk of fall. ...Read more

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Dr. Janice Alexander
133 doctors shared insights

Tizanidine (Definition)

Is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia, back pain, or certain other injuries to the spine ...Read more


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Can i take lithium and Zanaflex (tizanidine) together?

Can i take lithium and Zanaflex (tizanidine) together?

Caution warranted: Hopefully the same physician is prescribing all your medications, or at least knows all you're taking. Zanaflex (tizanidine) is a muscle relaxer that can cause drowsiness. This could be accentuated if you're on lithium. However, i see you're also on klonopin, which is more likely to cause sedation than lithium. Please discuss all these with your doctor and your pharmacist. ...Read more

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What are some of the dangers of zanaflex (tizanidine)?

What are some of the dangers of zanaflex (tizanidine)?

Allergic reactions: Zanaflex (tizanidine) commonly causes dry mouth and constipation, but in some people there are some dangerous potential effects, many of which are allergies (rash, hives, itching, and swollen airways causing breathing difficulties). Other dangers include potential liver damage and psychological effects such as hallucinations. If you have any side effect from any medication inform your doctor. ...Read more

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How long does it take for Zanaflex (tizanidine) to leave the body?

How long does it take for Zanaflex (tizanidine) to leave the body?

It takes...: 36 hours to get to 1% of your original levels, at which point it would be a non-issue! ...Read more

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I reached goal dose of zanaflex (tizanidine) may 18, but had some improvement in last couple days. Is this meds taking full effect or are my symptoms improving?

Hard to know: Firstly, good for you! The question might be possible to answer, but it requires sifting through all sorts of things - like what might be different in your life - what you are doing differently inside and out. You might want to find a good therapist to help you understand it all before you taper down. Never just stop w/o guidance. Happy for you! ...Read more

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Does zanaflex (tizanidine) work for anxiety?

Does zanaflex (tizanidine) work for anxiety?

NO: NO IT IS A MUSCLE RELAXANT. now if the patient anxiety coming from the pain associated with the muscle spasm then yes it mught work that way. ...Read more

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Dr. Tipu Sultan
124 doctors shared insights

Zanaflex (Definition)

Zanaflex is a muscle relaxant which is a ...Read more