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Doctor insights on: Xanax And Diphenhydramine

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Dr. Alan Ali
954 Doctors shared insights

Alprazolam (Definition)

Alprazolam is a short acting benzodiazepine, it does not last long in the system. So when used regularly with multiple doses to treat anxiety, it is associated with inter-dose withdrawal, tolerance and a resulting increase level of baseline anxiety. So in anxiety clinics, we use it only in cases of " flight, dentist or other infrequent anxieties, ...Read more


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What will happen if I take 2 mg of xanax (alprazolam) and 300 mg of diphenhydramine?

Don't!: That is way too much of both of them. Are you planning on hurting yourself? Please, don't! Call a suicide help line now, or tell your parents right away or go to the ER now! ...Read more

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I took 1 milagram of xanax awhile ago. Is it okay if I take benadryl (diphenhydramine)?

Yes: 25 mg Benadryl (diphenhydramine) is ok. Avoid Xanax in the future. It can be sedating, but highly addictive. Half life is 2-4 hrs so it's completely out of your system in 12 hrs. Rebound anxiety and insomnia can be worse than baseline leading to escalating dose. There are many more effective treatments for anxiety and insomnia ...Read more

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I take a mix of 200 mg of Diphenhydramine and 2 mg of Xanax (alprazolam) for sleep have been for 5 years. Dangers? How do I quit?

I take a mix of 200 mg of Diphenhydramine and 2 mg of Xanax (alprazolam) for sleep have been for 5 years. Dangers? How do I quit?

Addiction: Addiction is the primary danger, and inefficacy (sleeping drugs don't fundamentally work very we'll after so long). To get off these drugs you will need the help of a good sleep specialist or psychiatrist or addictionologist. ...Read more

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Can you take Benadryl (diphenhydramine) with Valium and xanax?

Can you take Benadryl (diphenhydramine) with Valium and xanax?

Benzos and Benadryl (diphenhydramine): First I need to question doses of xanax and valium and why you are taking 2 different benzodiazepines. Most people do not realize xanax is about 10x more potent than valium. So I don't see 25mg of Benadryl (diphenhydramine) as the primary issue. Do u have 2 different practitioners rx benzos? If so have only 1 captain running your ship & rxing meds. Discuss this with your rxing practitioner. ...Read more

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How can Benadryl (diphenhydramine) and Xanax differ when it comes to treating anxiety?

How can Benadryl (diphenhydramine) and Xanax differ when it comes to treating anxiety?

Very different med: Xanax and Benadryl (diphenhydramine) are two very different medications. Xanax is an anti anxiety medication approved for the treatment of anxiety. It is in the benzodiazepine class of medication so there is a risk of tolerance and withdrawal symptoms that lead to dependence. Benadryl (diphenhydramine) is an anti histamine approved for the treatment of allergy symptoms. It primarily produces drowsiness which can cover anxiety. ...Read more

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I'm out of Xanax and miserable. Should I try Benadryl (diphenhydramine) for some relief?

Xanax (alprazolam): U need to ask your prescribing physician first, to see if resuming xanax (alprazolam) is an option or finding another alternative medication. ...Read more

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Is it ok to take some liquid benadryl (diphenhydramine) now if I took a. 25 xanax at 6pm?

Benadryl (diphenhydramine): If over 2 hours after Xanax (alprazolam), (alprazolam) it is ok. The Xanax (alprazolam) dose is low anyway. Have good sleep. ...Read more

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I just took 2 tablets of 25mg benadryl (diphenhydramine) at 10 45pm. Is it okay if I take 0.25mg Xanax right now? It's 11 20pm

Not life threatening: Both of these medications are sedating & can make you groggy so operating a car of other machinery should be delayed. But it is not life threatening if you took that Xanax tonite & he only other medication on board was the Benadryl (diphenhydramine). You should have a doctor who prescribed the medication who you can speak with. If you want to have a virtual psychiatric consultation I am available thru Health Tap ...Read more

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I'm having a bad anxiety attack and I want more than my usual dose of xanax. Would it be okay to take a Benadryl (diphenhydramine) or two with it?

I'm having a bad anxiety attack and I want more than my usual dose of xanax. Would it be okay to take a Benadryl (diphenhydramine) or two with it?

Consult with MD: I can answer this question for my individual patients (whom I know well). However, this is really an important question for you to address with your physician. I am afraid that by telling you how to take your meds that I would be providing medical treatment (which only your providers should do). Take care. ...Read more

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I recently have been prescribed xanax. I took 1 pill. 25 at 11am. Is it safe to take a Benadryl (diphenhydramine) now at 10:04pm?? My allergies are bugging me.

Yes: It is almost 12hrs since you last xanax dose. The effect of xanax is usually much shorter than 12hrs, so it is safe to take benadryl (diphenhydramine). You may want to consider non-sedating antihistamine, like zyrtec, claritin, or allegra, which are generally safe to use with anti-anxiety medications. ...Read more

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Can my mom take phenobarbital and benadryl (diphenhydramine)? Dr took her off Xanax today and now on pheno instead but still can't sleep. Any recommendations?

Can my mom take phenobarbital and benadryl (diphenhydramine)? Dr took her off Xanax today and now on pheno instead but still can't sleep. Any recommendations?

Second opinion: Take your mom to a sleep specialist to get a second opinion...It's relatively uncommon to treat sleep problems with Phenobarbital these days. So when that happens, the important question is - why is this person having such difficulty with sleep that the doctor has to resort to phenobarbital? A sleep specialist is usually in the best position to answer that. ...Read more

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Can you help? Could rehab deal with a benadryl/xanax addiction?

Can you help? Could rehab deal with a benadryl/xanax addiction?

Yes: Xanax of course if a well known substance of abuse. However, the addiction Benadryl (diphenhydramine) is not unheard of and is dealt with at any reputable substance abuse center or by any professional with experience dealing with the myriad presentations of addiction. ...Read more

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Is it safe to take Abilify (aripiprazole) with Benadryl and xanax? It uses enzymes 2d6 & 3a4. Benadryl uses 2d6 and Xanax uses 3a4. Prescribed, of course. Curious..

Abilify (aripiprazole): It is safe to combine those medications. Regardless of their metabolic pathways, most likely there will be no important interactions in between them, and you will not notice any side effect related to their combination. Abilify (aripiprazole) may cause restlessness and Benadryl and xanax reduce restlessness, therefore they will reduce side effects. ...Read more

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I take Wellbutrin Sr. 150mg at 7 am and 5 pm. I also take. 25mg of Xanax twice a day. The last time was around 4pm. Can I take a Benadryl (diphenhydramine)? I have a co

Medication effects: Wellbutrin is for treatment of depression and Xanax is for treatment of anxiety.
Excessive use of Xanax, or abrupt stopping after long-term use may trigger seizures in patients taking Wellbutrin.
Wellbutrin may increase effects of Benadryl (diphenhydramine) - dizziness, confusion.
See Psychiatrist for Diagnosis; discuss medications, their benefits and side effects, dose, and interactions; and Therapy for stress. ...Read more

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Took my Adderall this afternoon, tiny piece of Xanax at night. All prescribed. Can I take a half of my Benadryl (diphenhydramine) for my allergies?

Took my Adderall this afternoon, tiny piece of Xanax at night. All prescribed. Can I take a half of my Benadryl (diphenhydramine) for my allergies?

12.5 mg?: Probably can do that without much of a problem. If you google 'anticholinergic side effects' you'll know what to look for. How late did you take the afternoon Adderall (dextroamphetamine and racemic amphetamine)?
I'd wait for it to wear off first. ...Read more

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Can I take Benadryl (diphenhydramine) to relieve serious allergies (sneezing, running nose, etc) and Xanax?

Can I take Benadryl (diphenhydramine) to relieve serious allergies (sneezing, running nose, etc) and Xanax?

Ask provider, but yes: It should be okay, but do talk w/ your provider since they can interact to increase dizziness and drowsiness risks. Perhaps your provider will offer an alternative or tell you a good schedule to take them on. Take care - allergies can be rough, I know. Also consider non-drug therapy for anxiety if possible. CBT can really help. And, no side efx! ...Read more

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I have a question about Diphenhydramines?

I have a question about Diphenhydramines?

Ask away: If you have a question about diphenhydramines, this site would be a good place to find the answer. Your next step would be to ask the question. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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What is Xanax (alprazolam) for?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
What is Xanax (alprazolam) for?

Xanax (alprazolam): An intermediate-acting benzodiazepine, it is used more often for panic disorder. ...Read more

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Is 150 mg of diphenhydramine okay?

Too much: This is too much diphenhydramine, you should not take such high doses before checking with a doctor or guided by a doctor. ...Read more

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Is 75mg of diphenhydramine an overdose?

75mg diphenhydramine: Is larger than a single dose should be for an adult or child. So it is technically an overdose. Normal doses for a child may be 75 to 150mg per day in divided dose or 150 to 300 mg per day in a divided dose for an adult. Are you considering taking an overdose? If you are -please have a friend or relative take you to the nearest er or call 911. With help your life and problems can improve. ...Read more

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What is Xanax (alprazolam) prescribed for?

Xanax: It is prescribed to treat Anxiety/ panic disorder. I try to avoid prescribing this class of medications as it can lead to development of tolerance. ...Read more

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What are Xanax (alprazolam) prescribed for?

What are Xanax (alprazolam) prescribed for?

ANXIETY: Xanax (alprazolam) is usefulin reducing anxiety. However, if anxiety is a problem, the cause of the problem is important -because when you know how something works and why, you can dosomething about it. Work out what this is about in therapy and maybe you won't need the xanax (alprazolam). ...Read more

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Is taking 300mg of diphenhydramine bad for you?

Probably: You may need up with very dry mouth, drowsiness, constipation, and even a fast heart rate from such a high dose. ...Read more

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What is half of a 0.5 milligram xanax (alprazolam)?

What is half of a 0.5 milligram xanax (alprazolam)?

0.25 mg: 0.5 mg/2 = 0.25 mg;

0.25 mg+.0.25 mg = 0.5 mg ...Read more

Xanax (Definition)

Alprazolam is a short-acting benzodiazepine which is a kind of sleep-inducing drug ...Read more


Dr. John Chiu
1,049 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more