Top
10
Doctor insights on: Xanax And Antihistamines

Share
1

1
After just one night of useing xanax, (alprazolam) antihistamines or melatonin to induce sleep, I am awake the entire night! never used to have this reaction. Why?

After just one night of useing xanax, (alprazolam) 
antihistamines or melatonin to induce sleep, I am awake the entire
night!  never used to have this reaction. Why?

Not the right combo: Each of these meds can help sleep or agitate. Combining them all on the first night? Melatonin is mostly benign but when used with vitamin b6 (think 5 hour energy) agitation can result. Some brands still include b6. Antihistamines are known to produce agitation in susceptible people. They learn who they are. Xanax (alprazolam) has a rapid onset but the rapid stop can agitate and cause reuse (think addiction). ...Read more

See 1 more doctor answer
Dr. Alan Ali
905 doctors shared insights

Alprazolam (Definition)

Alprazolam is a short acting benzodiazepine, it does not last long in the system . So when used regularly with multiple doses to treat anxiety, it is associated with inter-dose withdrawal, tolerance and a resulting increase level of baseline anxiety. So in anxiety clinics, we use it only in cases of " flight , dentist or other infrequent anxieties, ...Read more


2

2
After taking Xanax (alprazolam) or antihistamines or melatonin for just one night, i can't sleep at all the following night. Why?

After taking Xanax (alprazolam) or antihistamines or melatonin for
just one night, i can't sleep at all
the following night. Why?

Can't sleep: Not sure which medication u took that one night & why all 3 were prescribed at same time, unless u took one medicine each night & they all helped u sleep, then in that case u r having rebound insomnia as expected. ...Read more

3

3
I took an antihistamine & forgot I did. (15 min ago) came back in room & took a Xanax bc I've had anxiety all day. Can you mix those? Should I go to t

I took an antihistamine & forgot I did. (15 min ago) came back in room & took a Xanax bc I've had anxiety all day. Can you mix those? Should I go to t

Go to.....?: You should not mix Xanax with sedating antihistamines like diphenhydramine (Benadryl) since taking them together increases the sedative effect. If your doctor OK's it, you could use a less sedating antihistamine such as loratadine (Claritin) or fexofenadine (Allegra) with Xanax. As with any habit-forming drug, you should use Xanax sparingly at the lowest effective dose. Dr. Anne ...Read more

See 1 more doctor answer
4

4
I accidentally mixed an antihistamine with my Xanax?

Answered already: I have answered that this was likely ok. That you are reading this comment 8 hours after the question just confirms my opinion. ...Read more

6

6
I took 1 milagram of xanax awhile ago. is it okay if I take benadryl (diphenhydramine)?

Yes: 25 mg Benadryl (diphenhydramine) is ok. Avoid Xanax in the future. It can be sedating, but highly addictive. Half life is 2-4 hrs so it's completely out of your system in 12 hrs. Rebound anxiety and insomnia can be worse than baseline leading to escalating dose. There are many more effective treatments for anxiety and insomnia ...Read more

8

8
Can you take Benadryl (diphenhydramine) with Valium and xanax?

Can you take Benadryl (diphenhydramine) with Valium and xanax?

Benzos and Benadryl (diphenhydramine) : First i need to question doses of xanax and valium and why you are taking 2 different benzodiazepines. Most people do not realize xanax is about 10x more potent than valium. So i don't see 25mg of Benadryl (diphenhydramine) as the primary issue. Do u have 2 different practitioners rx benzos? If so have only 1 captain running your ship & rxing meds. Discuss this with your rxing practitioner. ...Read more

See 1 more doctor answer
9

9
How can Benadryl (diphenhydramine) and Xanax differ when it comes to treating anxiety?

Very different med: Xanax and Benadryl (diphenhydramine) are two very different medications. Xanax is an anti anxiety medication approved for the treatment of anxiety. It is in the benzodiazepine class of medication so there is a risk of tolerance and withdrawal symptoms that lead to dependence. Benadryl (diphenhydramine) is an anti histamine approved for the treatment of allergy symptoms. It primarily produces drowsiness which can cover anxiety. ...Read more

10

10
I'm out of Xanax and miserable. Should i try Benadryl (diphenhydramine) for some relief?

Xanax (alprazolam): U need to ask your prescribing physician first, to see if resuming xanax (alprazolam) is an option or finding another alternative medication. ...Read more

Xanax (Definition)

Alprazolam is a short-acting benzodiazepine which is a kind of sleep-inducing drug ...Read more


Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more