Doctor insights on:
Xanax And Antihistamines
After just one night of useing xanax, (alprazolam)
antihistamines or melatonin to induce sleep, I am awake the entire
night! never used to have this reaction. Why?
Not the right combo: Each of these meds can help sleep or agitate. Combining them all on the first night? Melatonin is mostly benign but when used with vitamin b6 (think 5 hour energy) agitation can result. Some brands still include b6. Antihistamines are known to produce agitation in susceptible people. They learn who they are. Xanax (alprazolam) has a rapid onset but the rapid stop can agitate and cause reuse (think addiction). ...Read moreSee 1 more doctor answer
Alprazolam is a short acting benzodiazepine, it does not last long in the system . So when used regularly with multiple doses to treat anxiety, it is associated with inter-dose withdrawal, tolerance and a resulting increase level of baseline anxiety. So in anxiety clinics, we use it only in cases of " flight , dentist or other infrequent anxieties, ...Read more
After taking Xanax (alprazolam) or antihistamines or melatonin for
just one night, i can't sleep at all
the following night. Why?
I took an antihistamine & forgot I did. (15 min ago) came back in room & took a Xanax bc I've had anxiety all day. Can you mix those? Should I go to t
Go to.....?: You should not mix Xanax with sedating antihistamines like diphenhydramine (Benadryl) since taking them together increases the sedative effect. If your doctor OK's it, you could use a less sedating antihistamine such as loratadine (Claritin) or fexofenadine (Allegra) with Xanax. As with any habit-forming drug, you should use Xanax sparingly at the lowest effective dose. Dr. Anne ...Read moreSee 1 more doctor answer
Answered already: I have answered that this was likely ok. That you are reading this comment 8 hours after the question just confirms my opinion. ...Read more
Yes: 25 mg Benadryl (diphenhydramine) is ok. Avoid Xanax in the future. It can be sedating, but highly addictive. Half life is 2-4 hrs so it's completely out of your system in 12 hrs. Rebound anxiety and insomnia can be worse than baseline leading to escalating dose. There are many more effective treatments for anxiety and insomnia ...Read more
I took a .25 mg Xanax about 5 hrs ago and was wondering if it's ok to take a benadryl (diphenhydramine)?
No problem: May produce a little sedation.Get a more detailed answer ›
Benzos and Benadryl (diphenhydramine) : First i need to question doses of xanax and valium and why you are taking 2 different benzodiazepines. Most people do not realize xanax is about 10x more potent than valium. So i don't see 25mg of Benadryl (diphenhydramine) as the primary issue. Do u have 2 different practitioners rx benzos? If so have only 1 captain running your ship & rxing meds. Discuss this with your rxing practitioner. ...Read moreSee 1 more doctor answer
Very different med: Xanax and Benadryl (diphenhydramine) are two very different medications. Xanax is an anti anxiety medication approved for the treatment of anxiety. It is in the benzodiazepine class of medication so there is a risk of tolerance and withdrawal symptoms that lead to dependence. Benadryl (diphenhydramine) is an anti histamine approved for the treatment of allergy symptoms. It primarily produces drowsiness which can cover anxiety. ...Read more