Doctor insights on:
Wound Healing With Thalassaemia Trait
Had a simple vulvectomy 5 wks ago-area of over-granulation tissue removed-no VIN. Wound healing well altho 1 stitch opened. Still have pain- normal?
Can happen but: Not common in all, will heal in couple of wks, and pain will go away once heals completely, don't worry you will be fine. ...Read more
Wound healing is a field of study in which a person looks at factors that helps wounds heal and factors that are harmful to wounds trying to heal, in order to find the best treatment for each wound. Wounds can be from infections, surgeries, accidents, etc... Poorly healing wounds can occur where there is inadequate blood circulation, such ...Read more
My partner is consistent with haemoglobin e-trait. I have normal hb chromatographic pattern. Is there any chance of thalassaemia of our new born baby?
Electrophoresis, but: Levels of hemoglobin h and hemoglobin barts should make the distinction straightforward though there may be modifying genes that could make interpretation. The real question is the implications in planning your family and for this perhaps you would like to have genetic testing done. Any hematologist would probably enjoy helping you out. Good luck. ...Read more
It is what it is. ..: Thalassemia is a number of inborn (genetic) disorders of hemoglobin (check out http://www. Mayoclinic. Com/health/thalassemia/ds00905 & http://www. Nhlbi. Nih. Gov/health/health-topics/topics/thalassemia/). Carries have just one gene while those w/full blown disorder have both. As a carrier, there're few clinical symptoms so it's "safe" for you, not that you could do anything about it! ...Read more
Thalassemias: Both α and β thalassemias are often inherited in an autosomal recessive fashion, although this is not always the case. Cases of dominantly inherited α and β thalassemias have been reported, the first of which was in an irish family with two deletions of 4 and 11 BP in exon 3 interrupted by an insertion of 5 BP in the β-globin gene. For the autosomal recessive forms both parents must be carriers. ...Read more
Can be: This is an inherited disease, commonly found in people with mediterranean ancestors. The body makes an abnormal amount of hemoglobin. You must be mindful of the higher risk of anemia due to the destruction of red blood cells. See your md for evaluation, treatment as needed, and monitoring. ...Read more
My grandfather a htn and CKD patient with dm and a thalassaemia carrier has just started dialysis at the age of 81 what are his chances of survival?
Time on dialysis: That is a difficult question to answer. You should ask his neprhologist for his opinion about your father's survival. The literature shows that 50% of patients starting dialysis over 75 years of age die within 2 years and the mean survival of that cohort is 31 months. A healthy male in the us has a life expectancy of 7.4 years at age 81. These data are for your information only. ...Read more
My daughter is a beta thalassaemia major patient & taking regular blood transfusion for 10 yrs. Now she has hep c type 4 &viral load is 133964. Cure?
Don't rush: Young people tend to have fairly slow progression of liver damage wit hepatitis c. The pace of new drug development over the next 5-10 years will transform this disease. Get informed. Follow sophisticated websites like natap. Org for the latest clinical trial data. Today, treatment of hcv in people like your child is complicated, but we will have easier to tolerate regimens in genotype 4 in 2-4 y. ...Read more
Complicated process: Multiple factors involved. White blood cells and platelets travel to the site for immune system and blood clotting. Collagen fibers heal across, and new blood vessels grow in. Collagen fibers remodel. Proper body protein level and appropriate vitamin levels help with healing. Poor nutrition, diabetes, cigarette smoking, infection, poor blood supply, Prednisone can delay or prevent proper healing. ...Read more
Likely: I don't find any studies that address this question on a quick search. Smoking cigarettes definitely has a negative effect on healing and I would expect that Cannabis would have the same effect, to the degree that toxins are found in the smoke. Cannabis oil has anecdotal positive effects, but not confirmed with studies to my knowledge, and that is oil applied to the skin, not smoked. ...Read more
Poor nutrition: Even a reasonably good diet usually is adequate for wound healing, there are no normal foods that will delay healing but certain dietary deficiencies, especially protein will. Deficient zinc or vitamin c may, diabetes has a negative effect even in ideal blood sugar control meaning elevated blood sugar is only part of the effect. ...Read more
Pharmacologically, the influence of smoking on wound healing is complicated, and neither nicotine alone nor any other single component can explain all of the effects of smoking on wounds. What is certain is that smoking cessation leads to improved repair and reduces wound infection (sorensen et al., 2003; lauerman, 2008).
www. Ncbi. Nlm. Nih. Gov/pmc/articles/pmc2903966. ...Read more
Although psychological issues may complicate wound healing and aromatherapy may have therapeutic benefits, the actual use of this in organized wound care is unusual.
Many different aromatherapy compounds are used for a variety of conditions, but none that I know are specific for wound healing. ...Read more
Amount?: Wound healing is a complicated process that requires many factors including building blocks (proteins) and fuel (fats and carbohydrates) as well as cofactors (vitamins and minerals). These are interrelated and work together. Poor nutrition means poor healing and poor immune responses. A little alcohol will have little effect. If you consume it at the expense of good nutrition, then healing slows. ...Read more
Absolutely: Steroids negatively affect wound healing by inhibiting the inflammatory response needed to start the healing process. Additionally exogenous or external steroids (even topical) will cause the wound and patient to be susceptible to opportunistic bacteria that may increase the risk of infection. ...Read more
All of them!: The real question is what slows down healing. Avoid applying alcohol, peroxide, hibiclens, betadine, and bleach solutions. Inflammation (red, hot, swollen, tender) is important to healing so anti-inflammatories (motrin, advil) are bad. Cover with a clean dressing changed every other day/protect from trauma. Antibiotics do not help healing unless it is truly infected. Good nutrition is key! ...Read more
Wound healing is a complex field and many treatment options are available. Epithelialization (skin regrowth) occurs after establishing a healing wound bed. More rapid healing of wounds may decrease scar tissue.
Bioengineered skin substitute (apligraf) can be used when appropriate to speed the healing of wounds, although oly approved for certain conditions. ...Read more
Interferes: In proper sound healing. Prevents inflammation, weakens tissues, decreases effectiveness of white blood cells, increased risks of infection, increases risk of diabetic tendency, can cause increased weight and tissue edema. Vitamin a can help counteract some of these steroid side effects on healing. ...Read more
Why it occurs?: Part of the body's response to a wound is the release of chemicals from inflammatory cells that cause the fine blood vessels (capillaries) to leak fluid from the blood stream. This allows certain elements in the blood to fight infection and also allows for easier healing. We often use dressings to keep a wound moist, so it is an adaptive response. Can also mean infection, so see MD if question. ...Read more
Highly variable.: There is no specific answer to this question because there are so many variables that can affect healing from one person to another. Wounds in this location can be very challenging as it requires another individual to carefully cleanse and properly dress the wound. In addition it is often affected by pressure from sitting and motion from activity which can inhibit the healing process. ...Read more
Few liquids actually: Promote wound healing. But there are some advantages to using a neosporin type cream. Also one can use certain silvadene (silver sulfadiazine) gels and seaweed extracts, but those are typically only obtained by prescription. Do not put hydrogen peroxide on a healing wound! Only use it to initially clean a wound. It kills the tissue that was placed down to heal it. Unsure of your documentation question, be specific. ...Read more
Wound healing and smoking. Can we smoke at lease three ciggrate per day while wound healing process.?
Not a good idea: Smoking inhibits wound healing at any rate of daily tobacco use. You should stop smoking not only for that, but for the known and unavoidable risk of lung disease that all smokers acquire. ...Read more
See your doc: Unfortunately, you didn't describe your wound, much less how you got it and how it was repaired. It would also be helpful to understand why you consider it abnormal. Wounds that come apart need to be re-evaluated. Same if increase pain, redness, pus, etc. Scar is an known complication. Some will develop an intense scar reaction known as a keloid. Best to see doc who put you back together. ...Read more
Needs a big textbook: Cytokines are released by lymphocytes and regulate other cells and parts or the immune system. Integrins directly "tell" immune cells what's going on in the "extracellular space" the immune system is the starting point for wound healing and these help regulate some of the cells involved as well as directly and indirectly affecting growth factors and matrix metaloproteinases needed to heal. ...Read more
Failure to rebuild.: An inability to restore structure and function to disrupted tissue by failure to progress through the normal stages of healing. ...Read more
My son has always healedvery well but recently he has developed slow wound healing. What could cause that?
Many Causes: There were many factors that affect wound healing. The term “slow” is difficult to define and therefore is really not important as long as the wound heals. Is he on a new medicine such as a NSAID? Is to located in an area that is getting a lot of activity? Keep the wound covered and minimize stress to the area, and change your dressing every other to every third day ...Read more