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Doctor insights on: Wilson S Disease

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With what medication should the wilson’s disease patient begin treatment?  

With what medication should the wilson’s disease patient begin treatment?  

Wilson's Disease: The problem is a build up of copper in the body, especially in the liver. Your doctor will prescribe a chelating agent that binds and gets rid of the copper, such as trientine. Once the levels are down, you will likely be given another medication to keep the copper levels low, such as zinc acetate. ...Read more

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What is the fate of someone who does not treat wilsons disease?

What is the fate of someone who does not treat wilsons disease?

Liver/neuro failure: Untreated, Wilson's disease can progress to liver failure and neurological disability and possibly death. With treatment, individuals with Wilson's disease have normal life expectancy. However, without treatment, individuals can expect issues with the brain, liver, eyes and psychiatric manifestations. Each individual is different so there are not set patterns of disease ...Read more

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If someone has wilsons disease, then how does he function compared to a normal person?

If someone has wilsons disease, then how does he function compared to a normal person?

Pretty normal: Until the wilson's disease causes liver function compromise, you should function normally. With proper treatment you should not have any functional problems. ...Read more

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What is cure for wilsons disease?

What is cure for wilsons disease?

Treatment: There is no cure. The treatment is to maintain a low copper diet. D-penicillamine and trientine are two drugs that are used to treat the copper overload. Both drugs require careful monitoring. ...Read more

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Hi. What is wilson disease diseas?

Hi. What is wilson disease diseas?

Copper: Wilson's disease is a disorder of copper metabolism causing too much copper in the blood and tissues. ...Read more

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What is the treatment for wilsons disease?

Remove copper: Excessive copper poisons the body organs, so the treatment is to remove the copper while stabilizing organs that may have been injured. This is called chelation. Several chemicals are used to remove the copper. See:
http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0001789/
also, www. Wilsonsdisease. Org. ...Read more

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How can I treat wilson disease?

Don't self-treat: Usually an oral medicine to manage copper is all that's required. Be very wary of "alternative and complementary" remedies in this very serious illness, and discuss anything you may be using with your gastroenterologist. I'm going to assume you have real Wilson's and not the "pop" Wilson syndrome, which is not a real illness. Best wishes. ...Read more

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How did wilson disease get its name?

How did wilson disease get its name?

Sam Wilson MD: 1878–1937, first described it and named it hepatolenticular degeneration. Perhaps the most treacherous diagnosis in general medicine, and unfortunately is still missed, which is bad because it's quite easy to manage and horrible if missed. There is also a bogus "wilson's disease" -- lay people are invited to self-diagnose as having subtle thyroid disease; no scientific basis. ...Read more

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What are the tests for wilson disease?

What are the tests for wilson disease?

It depends: Serum ceruloplasmin is often used and it is a poor choice as it misses about 30% of cases. Urine copper is my choice. If there's a family history or the diagnosis seems obvious, or urine copper is high, test the ATP7B gene. ...Read more

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At which age wilson disease excluded???

No age criteria: This is a disease mainly diagnosed based on symptoms and lab results. There is no cutoff in terms of age ...Read more

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What are some of the other symptoms of wilson disease?

What are some of the other symptoms of wilson disease?

Wilson Disease: The main organs affected by copper accumulation are the liver and brain, so your symptoms are refer able to these organs. You may experience cognitive impairment, bradykinesia, parkinsonian-like motor symptoms, other motor and sensory problems, fatigue, esophageal varices, liver and kidney disease, and, of course, the copper colored rings in your eyes. Cardiac involvement can also intervene. ...Read more

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What is wilson disease? What is the problem in the body?

What is wilson disease? What is the problem in the body?

Mutated ATP7B: The cells can't transport copper out of their cytoplasm as they should. This cases the complications of liver cell death and cirrhosis, brain damage, and so forth. ...Read more

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Hi I suffer from serious cronic migraines almost 4 years now. I take lots of medicine. I also have wilsons disease.

Hi I suffer from serious cronic migraines almost 4 years now. I take lots of medicine. I also have wilsons disease.

Expert Tx: I hope you're under the care of the very best possible rxperts since it can make a big difference in Wilson's. If possible do some research to find the very best. The varied effects of the disease may interact w/ other conditions and frustrate efforts otherwise. The meds you need may have painful side effects and supportive psychotherapy can help you to understand and deal w/ this. ...Read more

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What kind of doctor would I want to be in the care of for Wilsons Disease?

Multidisciplinary: A multidisciplinary medical team would serve a patient like this the best. You may need a GI specialist, neurologist, psychiatrist and PCP to work together to help patient with chronic issues. ...Read more

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Does Wilsons Disease show on an EEG?

Does Wilsons Disease show on an EEG?

Wilsons disease: Can cause hepatic encephalopathy which in turn can produce slow anterior triphasic waves on an EEG in the absence of liver failure it would not likely produce changes on an EEG. There are labs tests and eye findings that may be helpful in arriving at a diagnosis. ...Read more

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Can wilsons disease mimic parkinsons?

Yes: Parkinson-like symptoms can be an initial manifestation of Wilson's disease. Wilson's disease usually occurs in younger people, however. If there is any confusion in diagnosis, Wilson's disease can usually be diagnosed through a combination of blood tests, urine tests, and/or an eye exam. Hope this helps. ...Read more

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Do people with wilson disease have a lot of pain?

Do people with wilson disease have a lot of pain?

No: Movement disorder--deterioration of cognition--hepatitis---joint pain is not very significant--but they get a variety of symptom--ask your doctor. ...Read more

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Describe the treatments enzyme substitution in wilson disease?

Describe the treatments enzyme substitution in wilson disease?

Wilson disease: Excess opper accumulation with serious end organ damage. Treatment after diagnosis is chelation therapy to diseaseexcess copper. Then avoidance of reaccumulation. See mayo clini wilsons disease well written and presented for non medical personnel. ...Read more

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Can you provide an overview of how wilson disease affects the liver?  

Could be bad: Wilson's disease leads to copper accumulation in the body - brain/liver/eyes and elsewhere - what it does to the liver? Well - imagine if you stuff your car engine with mud -things get, well, 'mucked up' - well that's the livers story - the liver does lots of stuff in the body - breaks down bad stuff, makes good stuff - and, is in the center of the circulation highway -so, muck up the liver and.. ...Read more

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I have low ceruloplasmin on blood test, so what are the chances I have wilson disease?

I have low ceruloplasmin on blood test, so what are the chances I have wilson disease?

Need more workup: Low ceruloplasmin by itself is not diagnostic of wilson disease.
Decreased ceruloplasmin and blood copper concentrations and increased urine copper levels may indicate wilson disease. Definitive diagnosis may require a liver biopsy. ...Read more

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My dr. Says I have high copper in my blood (serum copper). Could I have wilson disease?  

My dr. Says I have high copper in my blood (serum copper). Could I have wilson disease?  

Need tests: Most cases of wilson disease show symptoms between childhood and early adulthood, some may present in their 30's and 40's. Diagnosis is made by blood, urine tests and an eye examination for kayser-fleischer rings (copper deposit around the cornea). Liver biopsy and genetic tests are also options. Not all patients experience the same set of symptoms or timeline, so thorough testing is important. ...Read more

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When liver enzymes started to elevated in wilson disease??

Varies: Wilson's in infamous as an elusive diagnosis, which is unfortunate because it is so deadly if missed but easy to treat if found early. Usually the liver enzymes are up for a few years before the person gets super-sick. This the time during which we hope to make the diagnosis. ...Read more

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Can prenatal vitamins or other vitamins cause wilson disease?

No: Prenatal vitamins taken during pregnancy offer more help than potential side-effects unless a woman already has a severe metabolic problem. Wilson disease is a metabolic problem causing an over accumulation of copper. Vitamins do not cause it. However, vitamins can contain an excess of certain minerals and may not be necessary in the non-pregnant state. ...Read more

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What genetic testing is currently available for wilson disease?

What genetic testing is currently available for wilson disease?

ATP7B: This is routine and is available upon request from the major gene labs. ...Read more

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Should I see a specialist for wilson disease, or can my regular doctor take care of it?

It's your choice: Managing Wilson's is usually very easy and if your personal physician feels comfortable with it and knows what to watch for, and you're good with it, stay with him/her. ...Read more

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Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?

Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?

Minor mystery: We do know that the liver tends to underproduce ceruloplasmin in Wilson's, but this is only the case in about 2/3 of patients and it is famously unreliable as a way of screening. The exact mechanisms still haven't been sorted out. ...Read more

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I have Low caeruloplamin 0.19g/L and low serum copper 12.5 umol/L - units (Australian). Do I have Wilson Disease? Or Copper deficiency? Thanks.

Finish workup: If there is any concern at all that you have Wilson's, get a proper screen -- urinary copper and perhaps a genetic screen if you've got suggestive symptoms. Missing Wilson's leads to one of the most grisly deaths possible. Managing it is easy. Your ceruloplasmin is trivially low and reference ranges are set so that a few percent of healthies are outside on either end. ...Read more

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What to do if I have rings around my eyes when I was a preteen. If you have kayser-fleischer rings does it mean you have wilsons disease or could it be something normal?

What to do if I have rings around my eyes when I was a preteen. If you have kayser-fleischer rings does it mean you have wilsons disease or could it be something normal?

Let's sort this out: You had rings around your IRISES (actually the plural is irides, but never mind), not your "eyes" (like a raccoon) when you were young and they went away? That's the opposite of what happens with Kayser-Fleischer rings. If you're normal at 35, you don't have Wilson's disease. What to do is nothing. Give my regards to Broad Street. (My compliments for spelling Kayser-Fleischer correctly, BTW.) ...Read more