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Doctor insights on: Wilson Disease Carrier Eligible To Donate Liver

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Can a carrier (heterozygote) of the wilson disease gene donate part of his/her liver tissue for a living related donor transplant to a patient?

Can a carrier (heterozygote) of the wilson disease gene donate part of his/her liver tissue for a living related donor transplant to a patient?

Yes: Wilsons disease is a disease of copper storage. It is genetically linked. Generally speaking people who are heterozygous (are only carriers) can donate their part of thier livers. People who are heterozygous are carriers and don't have wilson's disease themselves. ...Read more

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Dr. Daniel Saurborn
2 doctors shared insights

Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


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Can you provide an overview of how wilson disease affects the liver? 

Can you provide an overview of how wilson disease affects the liver? 

See below: Excessive deposition of copper in various tissue including liver, brain and eyes results in tissue damage. See this site for more info. http://www.mayoclinic.com/health/wilsons-disease/ds00411. ...Read more

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When liver enzymes started to elevated in wilson disease ??

When liver enzymes started to elevated in wilson disease ??

Varies: Wilson's in infamous as an elusive diagnosis, which is unfortunate because it is so deadly if missed but easy to treat if found early. Usually the liver enzymes are up for a few years before the person gets super-sick. This the time during which we hope to make the diagnosis. ...Read more

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Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?

Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?

Minor mystery: We do know that the liver tends to underproduce ceruloplasmin in Wilson's, but this is only the case in about 2/3 of patients and it is famously unreliable as a way of screening. The exact mechanisms still haven't been sorted out. ...Read more

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What are some of the other symptoms of wilson disease?

What are some of the other symptoms of wilson disease?

Wilson Disease: The main organs affected by copper accumulation are the liver and brain, so your symptoms are refer able to these organs. You may experience cognitive impairment, bradykinesia, parkinsonian-like motor symptoms, other motor and sensory problems, fatigue, esophageal varices, liver and kidney disease, and, of course, the copper colored rings in your eyes. Cardiac involvement can also intervene. ...Read more

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Do people with wilson disease have a lot of pain?

Do people with wilson disease have a lot of pain?

No: Movement disorder--deterioration of cognition--hepatitis---joint pain is not very significant--but they get a variety of symptom--ask your doctor. ...Read more

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How can I treat wilson disease?

Don't self-treat: Usually an oral medicine to manage copper is all that's required. Be very wary of "alternative and complementary" remedies in this very serious illness, and discuss anything you may be using with your gastroenterologist. I'm going to assume you have real Wilson's and not the "pop" Wilson syndrome, which is not a real illness. Best wishes. ...Read more

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Hi. What is wilson disease diseas?

Hi. What is wilson disease diseas?

Copper: Wilson's disease is a disorder of copper metabolism causing too much copper in the blood and tissues. ...Read more

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How did wilson disease get its name?

How did wilson disease get its name?

Sam Wilson MD: 1878–1937, first described it and named it hepatolenticular degeneration. Perhaps the most treacherous diagnosis in general medicine, and unfortunately is still missed, which is bad because it's quite easy to manage and horrible if missed. There is also a bogus "wilson's disease" -- lay people are invited to self-diagnose as having subtle thyroid disease; no scientific basis. ...Read more

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What are the tests for wilson disease?

What are the tests for wilson disease?

It depends: Serum ceruloplasmin is often used and it is a poor choice as it misses about 30% of cases. Urine copper is my choice. If there's a family history or the diagnosis seems obvious, or urine copper is high, test the ATP7B gene. ...Read more

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Dr. Robert Hutchman
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Wilson's Disease (Definition)

Wilson disease is a genetic condition in which a person's body cannot handle the normal amount of copper obtained through foods. Over time, the copper accumulates in the body and damages the ...Read more