Doctor insights on:
Wilson Disease Carrier Eligible To Donate Liver
Can a carrier (heterozygote) of the wilson disease gene donate part of his/her liver tissue for a living related donor transplant to a patient?
Yes: Wilsons disease is a disease of copper storage. It is genetically linked. Generally speaking people who are heterozygous (are only carriers) can donate their part of thier livers. People who are heterozygous are carriers and don't have wilson's disease themselves. ...Read moreSee 1 more doctor answer
This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more
Varies: Wilson's in infamous as an elusive diagnosis, which is unfortunate because it is so deadly if missed but easy to treat if found early. Usually the liver enzymes are up for a few years before the person gets super-sick. This the time during which we hope to make the diagnosis. ...Read more
Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?
Wilson Disease: The main organs affected by copper accumulation are the liver and brain, so your symptoms are refer able to these organs. You may experience cognitive impairment, bradykinesia, parkinsonian-like motor symptoms, other motor and sensory problems, fatigue, esophageal varices, liver and kidney disease, and, of course, the copper colored rings in your eyes. Cardiac involvement can also intervene. ...Read moreSee 2 more doctor answers
Need tests: Most cases of wilson disease show symptoms between childhood and early adulthood, some may present in their 30's and 40's. Diagnosis is made by blood, urine tests and an eye examination for kayser-fleischer rings (copper deposit around the cornea). Liver biopsy and genetic tests are also options. Not all patients experience the same set of symptoms or timeline, so thorough testing is important. ...Read moreSee 2 more doctor answers
Wilson disease: Excess opper accumulation with serious end organ damage. Treatment after diagnosis is chelation therapy to diseaseexcess copper. Then avoidance of reaccumulation. See mayo clini wilsons disease well written and presented for non medical personnel. ...Read moreSee 1 more doctor answer
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