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Doctor insights on: Will Zoloft Get You High

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I get these random spells of feeling "high"at times. I don't use any drugs and I'm wondering is it from weaning off of 50 mg Zoloft (sertraline) or sleep deprived.

I get these random spells of feeling "high"at times. I don't use any drugs and I'm wondering is it from weaning off of 50 mg Zoloft (sertraline) or sleep deprived.

Hard to say: Zoloft (sertraline) discontinuance ax are usually flu like sz, dizziness & brain zaps--sleep deprivation might be a factor. Or could be another condition

Dr. Heidi Fowler
1,074 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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Breastfeeding on 50mg Zoloft (sertraline). Need to go up to 75 but worried about baby getting more medication. Is 75 a high dose while nursing? Will she get more?

Breastfeeding on 50mg Zoloft (sertraline). Need to go up to 75 but worried about baby getting more medication. Is 75 a high dose while nursing? Will she get more?

Not really : The AAP released an article on 8/23/2013 advising that most medications are safe for breastfeeding mothers, although antidepressants were cited as ones with potential problems, yet it wasn't recommended to stop it, the NIH Toxnet and Lactmed databases didn't recommend stopping it either, check them for more information. You want to tell your child 's pediatrician about it too, enjoy your baby

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Iv been taking Zoloft (sertraline) for 2 months, my anxiety is under control, but IV noticed that i don't get as excited anymore about happy stuff. Is this normal?

Yes: Antidepressants like zoloft (sertraline) do have side effects. Some patients feel that their mood sort of flattens out and they do not get overly excited or angry in appropriate situations. Usually as the depression lifts with appropriate dose, then the mood improves and energy & motivation is restored. Continue taking your medicine and discuss this issue with your physician on next appointment.

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Zoloft (sertraline) has helped my anxiety but now i feel in between emotions. I don't get overly excited like I use to and i don't get down as much.Is this normal?

Paradox with Zoloft (sertraline): It is possible to have a paradoxical reaction to an antidepressant such as zoloft (sertraline). These reactions: increasing anxiety or feeling no emotions means it is time to try a new medication. This is not dangerous but it is common and needs to be addressed by the professional who you have been working wth.

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If im taking zoloft 150mg and abilify (aripiprazole) 2mg is that correct or zoloft too high?

If im taking zoloft 150mg and abilify (aripiprazole) 2mg is that correct or zoloft too high?

Zoloft (sertraline) can be higher: these are appropriate doses of both zoloft and abilify (aripiprazole) and it is not unusual to see higher doses of both

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Can kids get hi off their zoloft (sertraline)?

NO: Any side effect is possible in a given patient. Sertraline (zoloft) is usually a calming agent.

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How to determine when to get off zoloft (sertraline)?

How to determine when to get off zoloft (sertraline)?

Zoloft (sertraline): If develop allergic reaction, intolerable side-effects, or if advised by your doctor.

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How long can Zoloft (sertraline) take to get out of your system?

How long can Zoloft (sertraline) take to get out of your system?

Male or woman: Depends. Its half life is long. Average is considered about 24 hours just to get half of it out of your body. It may be 1.5 times longer in women. And, remember, the next 24 hours just gets half of the remaining half out of you.

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Can Zoloft (sertraline) cause someone to get angry or in a fit of rage often? I've read that it can and its somewhat common, is that true?

Can Zoloft (sertraline) cause someone to get angry or in a fit of rage often? I've read  that it can and its somewhat common, is that true?

It is reported: Any of the drugs known as ssri's can and have been reported to cause mood swings such as drowsiness ; lethargy to anger and rage or even suicide. Their effectiveness according to long term population studies has been brought into question as of late and some suggest that as a class of drug it is being overprescribed to the general population.

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I asked a question before about which could medications I could take with zoloft (sertraline). I didn't get an answer, and I can't sleep due to this cough.

I asked a question before about which could medications I could take with zoloft (sertraline). I didn't get an answer, and I can't sleep due to this cough.

Some remedies: A mixture of chamomile tea with honey & a small amount of lemon juice may help. Pour boiling water over thinly sliced organic ginger. Steep for at least five minutes in a covered pot. Add 2 to 3 tbs of honey & sip. Hydrate well with broth or water. These are just a few options. Take care.

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I'm on Zoloft (sertraline) 50mg BD, Clomfranil 25mg OD. I can't get rid of a thought about an argument made with someone? Its really painful. Any advise please

I'm on Zoloft (sertraline) 50mg BD, Clomfranil 25mg OD.
I can't get rid of a  thought about an argument made with someone? Its really painful. Any advise please

More OCD treatment: It looks like you're being treated for depression and OCD. It also sounds like the treatment for the OCD is NOT working well- suggest you get in to see and talk to a psychologist and psychiatrist to sort things out. Go easy on yourself, and trust it will get better with time and regular medication

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I've been on Zoloft (sertraline) 150mg for years now and my anxiety is under control but the last few days i can't sleep and im not anxious i done get it, what coul?

I've been on Zoloft (sertraline) 150mg for years now and my anxiety is under control but the last few days i can't sleep and im not anxious i done get it, what coul?

Anxiety ; insomnia: Have you added any new medicines, supplements, or recreational drugs -- or stopped any of the same? Do you drink alcohol? Any changes to your pre-sleep routine? Anything worrisome on your mind? How is your mood, and your energy? These are some things i'd ask in working with you -- your own psychiatrist will want to know the same. Cognitive behavioral therapy can help w/insomnia also.

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I mixed Zoloft (sertraline) with methamphetamines. I'm Hallucinating. Too high. Should i be concerned?

ER: Get to an emergency room right this minute! Shut the computer off, and go to your local emergency room right now. Dial 911, because likely you are not safe to drive. Or have a friend drive you there. Again do it right this minute!

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How common is it to get side effects from taking zoloft (sertraline)?

How common is it to get side effects from taking zoloft (sertraline)?

Common: Side effects are common early on & most often diminish over time (a week or 2). If they are serious, fail to diminish, or are intolerable, then contact your prescriber immediately for instructions & consideration of alternative medication. See comment below.

Dr. Alan Ali Dr. Ali
2 doctors agreed:
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Any advice on how i get better deal with Zoloft (sertraline) withdrawals?

Dr. Alan Ali Dr. Ali
2 doctors agreed:

Zoloft (sertraline): Depends on what dosage u r currently on, & reasons zoloft (sertraline) was prescribed. Gradual tapering over several weeks is duable, with guidance of your prescribing doctor.

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Dr. Alan Ali Dr. Ali
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How best to get out of zoloft (sertraline)? My sister is always lethargic.

Dr. Alan Ali Dr. Ali
1 doctor agreed:
How best to get out of zoloft (sertraline)? My sister is always lethargic.

Zoloft (sertraline): Best to consult the prescribing doctor who knows the case & can give best advise.

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How can I get the comparison of chemical structures for Zoloft (sertraline) and Valium?

PDR: PDR= Physicians Desk Reference has photos of the chemical structure. It is very reliable and updates yearly.

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Can I take 25mg of Zoloft (sertraline) twice daily ? When I take 50mg at once I get horrible side effects

Yes: Dividing the dose to Zoloft (sertraline) 25 mg twice daily is fine. Try to take consistently at the same time each day. Be sure to discuss with prescribing doctor.

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Dr. Alan Ali
1,029 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more