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Doctor insights on: Will There Be Immunocompromise With Alpha Thalassemia

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Will there be immunocompromise with alpha thalassemia?

Will there be immunocompromise with alpha thalassemia?

Not directly.: Thalassemia affects red cells while immunity is related to white cells. However, with severe thalassemia, life-saving treatment may cause immunocompromise as a side effect. ...Read more

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Dr. Stephen Scholand
30 doctors shared insights

Hemoglobin H Disease (Definition)

Hemoglobin is composed of alpha and beta chains. In hemoglobin H disease, the beta chains are normal but there is little or ...Read more


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What is alpha thalassemia disorder?

What is alpha thalassemia disorder?

Hemoglobin problem: Alpha thal is caused by mutations that effect the production of a part of the hemoglobin molecule (Alpha chain). There are 4 genes involved in this production. Mutations can occur in 1 to 4 of these genes. The disease is more problematic the more genes are mutated. This disease is inherited from parents. ...Read more

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Does alpha thalassemia causes leukemia?

Does alpha thalassemia causes leukemia?

No: Alpha and beta thalassemia have not been reported to cause leukemia, which is cancer of the white blood cells. There is a study of beta thal. Major & intermedia patients in iran, where researchers found 5 leukemia cases in about 4, 600 patients. That is a higher rate of leukemia than in the general population there, but details were unavailable as to what other factors were present in the patients. ...Read more

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Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more

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Is it possible to have both alpha thalassemia and beta thalassemia?

Is it possible to have both alpha thalassemia and beta thalassemia?

Traits, yes: Because the Alpha and beta thalassemia gene mutations are common, it is possible for a baby to inherit one from mom and another from dad. The child could be "trait" in both Alpha and beta, or less likely, be "disease" in one and "trait" in the other. It is hard to imagine being "disease" in both and still survive. ...Read more

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Can a person with alpha thalassemia marry someone with beta thalassemia safely?

Yes: Marriage is no problem. Getting pregnant, however, may not be recommended if they have moderate or severe thalassemia. If they have only "trait", they will be fine if their children only inherit "no trait" or "trait from either mom or dad". If a child inherits "trait" from both mom and dad, the child might have a problem. A geneticist and hematologist can give more details for individual cases. ...Read more

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How was alpha thalassemia named?

Conventional: As scientists investigated hemoglobin, the complicated compound in red blood cells that carries oxygen, they learned that it was made up of 5 parts; 4 of these are 2 copies each of 2 different proteins. They named these Alpha chains and beta chains. If you inherit a condition where the Alpha chains are produced in smaller amounts than normal, you have Alpha thalassemia. ...Read more

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Can alpha thalassemia be dominant?

Can alpha thalassemia be dominant?

Not quite: People normally have 4 Alpha globulin genes. A mutation in 1, 2, 3, or all 4 genes leads to the 4 levels of Alpha thalassemia. The genetics of the disorder is not all-or-none, not dominant-recessive. Instead, the more mutations, the worse the disease. One mutation = silent carrier (no symptoms), 2 muta. = Alpha trait (mild symptoms), 3 muta. = HGB h (moderate symptoms), 4 muta. = bart's (deaths). ...Read more

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How can one inherit alpha thalassemia?

4 alpha genes...: It is a bit complicated given that there are 4 Alpha chain genes and Alpha thalassemia can involve mutations in one, two (in two different ways) or three genes (mutations in four genes is usually not compatible with life). For excellent website, see: http://www.Stjude.Org/stjude/v/index.Jsp?Vgnextoid=d966885309c6f110vgnvcm1000001e0215acrcrd. ...Read more

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Emily Lu Dr. Lu
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Who is at risk of getting alpha thalassemia?

Emily Lu Dr. Lu
2 doctors agreed:

Family history: Thalassemia is a genetic disease of the hemoglobin molecule and so only occurs through inheritance. A mutation in this gene is especially prevalent in persons of african, asian, middle eastern or mediterranean descent. Individuals with only one mutation of the gene will be asymptomatic, so genetic screening is necessary to precisely determine risk. ...Read more

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What are the common symptoms of alpha thalassemia?

None to severe/fatal: Alpha thalassemia signs and symptoms: silent carriers have no signs/symptoms; Alpha trait has mild anemia; HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's disease (severe) is usually fatal before birth. ...Read more

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What are the long-term consequences of alpha thalassemia?

None to severe/fatal: Alpha thalassemia signs and symptoms: silent carriers have no signs/symptoms (and live a normal life); Alpha trait has mild anemia (and generally live a normal life); HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's disease (severe) is usually fatal before birth. ...Read more

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Alpha thalassemia, what does it mean and what are the implications?

Inherited defect: Our regular hemoglobin is composed of Alpha and beta chains that come together to form working hemaglobin. Alpha thalassemia trait occurs when a person inherits a defective Alpha chain gene from one parent & a normal Alpha chain gene from the other. This causes some reduction in Alpha chain production with resulting mild anemia. ...Read more

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I am 24 and my height is 5'5" and weight 42kg. How can I gain weight. I have alpha thalassemia. Please help.

I am 24 and my height is 5'5" and weight 42kg. How can I gain weight. I have alpha thalassemia. Please help.

Yes: Your height may be within the range but you are just short. Your internist must put you on the growth chart which tells you if you are at the lower end of norms. Because of thalassemia, your internist will consult a hematologist and get complete details about the condition. He will then do some endocrine studies especially for pituitary and thyroid. He may get some x-rays of long bones ...Read more

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Does alpha thalassemia cause pvcs?

Probably not: Alpha thalassemia probably doesn't cause pvc's (premature ventricular beats, a type of extra heartbeat). However, some thalassemia patients have magnesium deficiency, which can make pvc's more likely to occur. Patients who get transfusions off and on may be drinking lots of coffee, using caffeine or phenols in coffee to decrease iron absorption, to hold off iron overload. Caffeine can cause pvc's. ...Read more

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Dr. Michael Gabor
32 doctors shared insights

Alpha Thalassemia (Definition)

A blood disorder that reduces the production of hemoglobin (the protein in red blood cells that carries oxygen to ...Read more


Immunocompromised (Definition)

Incapable of developing a normal immune response, usually as a result of disease, ...Read more