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Will Smoking Effect My Itp Disorder
Clubbed index and middle fingers. Chest xray 10 months ago. 26/f. No smoking. Should I be worried? IBS, ITP and hashimotos. Could these cause clubbing
Autoimmune disease: Idiopathic thrombocytopenic purpura (itp) is an autoimmune disease. In this potentially life-threatening disorder self antibodies directed against platelets result in low levels of platelets in the blood. Platelets are necessary for effective blood clotting. People with itp can die from loss of blood after trauma of from a brain hemorrhage. Death is not a psychosomatic disease. ...Read more
Hi. I have a sister, she's 15 years old. She has a the disease itp. Is there a way to cure her? What kind of testing is necessary for her?
Disease called itp dr keeps me on these IV treatments. Of dexamethasone, zofram, benadryl.2 tylenol (acetaminophen) and 5000 units of winrho. Is this tolong to be on?
If a mother is pregnant and gets itp while pregnant, does the baby contract this disease at the same time?
Passive transfer can: Unfortunately, the maternal antibodies are usually of the IgG class and can cross the placenta, more commonly in very late pregnancy. If this does occur it is of short duration, since the child makes no platelet antibodies. It is not severe for most, if it does occur. ...Read more
I had bloodwork done and my platelet count was 201, monocytes 6.8%, eosinophils 3.7% basophils 0.2%. fhx of immune disorders ITP and others. Advice?
Platelet count: 160k/may 110k/august 92k/september 93k/november. Rest of blood report normal. No bleeding disorder in family. No other symptoms. Itp?
I have ITP and now Graves disease, Endo wants me to undergo Radioactive Iodine treatment, how will this affect my ITP?
Unusual combo: This is an unusual combination of autoimmune diseases. There is little in the literature for guidance, but a few case reports indicate that the ITP may get better with treatment of the Graves with methimazole. Although I cannot think of any way that RAI should affect your ITP, RAI can sometimes activate the immune system and worsen Graves eye disease. ...Read more
ITP being an auto-immune disease, would a diet with less vitamin A, C and B6, proteins and probiotics to reduce the immune response be useful?
No: ITP is an autoimmune disease in which platelets are destroyed and maybe even inhibited in production. Depending on the platelet count and clinical findings treatment can range from observation follow-up to multiple drug regimens. Dietary changes other than a well balanced and nutritional diet do not help. ...Read more
Can be, but rare: Most people w/ treated itp can expect to live a normal life span. Platelets help the blood clot, so a person w/ extremely low platelets (due to immune system attack in itp) can have fatal bleeding esp in the brain. However, this happens <1% of the time. Your doctor will monitor your platelets, and there are many treatments for itp such as Prednisone that can help maintain a good platelet count. ...Read more
Most patients are able to recover platelet counts and have a mortality rate similar to the general population. For more details see this link.
http://bloodjournal. Hematologylibrary. Org/content/97/9/2549.long. ...Read more
It's very rare, but: Does happen. If ones platelet count fall to low enough, spontaneous bleeding can occur. Head bleeds, for example, can be both spontaneous and life-threatening. That being said, the plts that a person with itp does have tend to be more thrombofenic because they are "younger". This helps to mitigate the consequences of low PLT count. Your dr. Can give you additional info. Good luck. ...Read more
Response rate 20-30%: Recent review in blood in may 2012 looked at several articles and found a 5-year response rate in adults to be around 26%. Meaning these patients had a sustained elevation of their platelet count for 5 years. Initially the response rate is close to 60%. It is given weekly for 4 weeks. So in summary, it works well. Hope this helps. ...Read more
Bleeding: You should seek medical care when you notice an increase in the frequency or severity of bruising or bleeding. It does not necessarily require a visit to an emergency room, but you should at least contact your hematologist. ...Read more
What are the possible causes of both ITP & Bernard-Soulier Syndrome in a person? What effect, if any, do they have together? Thanks for your input.
Platelet troubles: Bernard-Soulier features a small number of large platelets, lifelong and without autimmunity being a factor. In ITP, the immune system destroys platelets and those that remain are often quite large. It's possible that you have only one of these, as both feature a diminished number of platelets and increased platelet size. Get a review by a good up-to-date hematologist. ...Read more
I would ask your Dr.: Sometimes patients with itp will end up on a chronic medical regimen because efforts to wean off their rx leads to recurrent bleeding. For example, after a course of steroids you may be able to wean to a vey low, even every other day dose, but complete discontinuation leads to bleeding reminiscent of the original diagnosis. With new options for medical mgmt, may be time to revisit this issue. ...Read more
Many options....: Traditionally, acute itp was treated with ivig, which leverages anti-idiotype effect and fc receptor engagement to block PLT degradation. Winrho has been used. It recognizes a protein on the surface of red cells and essentially ties up the reticuloendothelial system. But it causes a mild anemia, so has fallen out of favor. Steroids, rituximab, splenectomy, and thrombopoietin agonists r options. ...Read more
Ask your doctor for individual recommendations
Theoretically if platelet count is good (bleeding risk is controlled) then the steroid would not be contraindicated but if you are already receiving steroids ITP treatment then I'm not sure how much more an injection has to offer. ...Read more
ITP: Thrombocytopenia or low platelet level can be caused by so many things such as drugs, platelet consumption by clots, infections, vitamin deficiency, cancer related etc. Your doctor has to rule out all those possibilities and ultimately to do a bone marrow biopsy to eval bone marrow. See your md and discuss further re-diagnosis approach/treatment and other things you need to know re - itp. ...Read more
Symptom: Most of the time itp patients are asymptomatic and the only abnormality they have is the low platelet level on their blood counts. They can have bruising, tiny red dots on the skin, roof of the mouth etc- (ptechiae) or other type of bleeding such as bleeding in the gum, only if platelet level goes down really low-below 30k or so. ...Read more
Oral steroids: Idiopathic thrombocytopenic purpura is a condition in which autoimmune antibodies against platelets causes an increased rate of destruction. Platelets are needed for normal blood clotting. Heavy periods, nose bleeding, easy brusing, and a rash (purpura) may suggest this problem. Diagnosis requires a blood count and blood clottting studies. Treatment begins with steroids (prednisone). ...Read more
In the old days....: The "i" in itp stood for idiopathic, which means we didn't know what was causing the problem. We now know this to be an autoimmune process where antibodies recognize proteins on the surface of platelets and target them for destruction by the reticuloendothelial system. Most cases follow an infection (usually viral), but they can also be the presenting feature of autoimmune disorders or malignancy. ...Read more
In most cases, itp in children resolves on its own. Your child’s blood may be tested weekly or at longer intervals until the platelet count has returned to normal.
Treatment may be recommended based upon the platelet count, age of the patient, activity level and bleeding symptoms. When treatment is recommended, it may involve the following medications that help keep platelet counts at a safe leve. ...Read more
Bruising, bleeding: People with itp may be at an increased risk of bruising or bleeding, depending on the platelet count and other factors, such as medications. If needed, itp can be treated with steroids or other medications. In some instances, removing the spleen (splenectomy) may be recommended. If you are to require surgery, the surgeon should be made aware of this condition. ...Read more
Good question: What treatments have you had? The medical treatments have typically included steroids, other immunosuppressive medications, rituximab. These medications do not always work, and sometimes they only work temporarily. The main surgical treatment is splenectomy. This does not always work either. The goal is to keep you platelets high enough so that you are not having frequent bleeding. Good luck. ...Read more
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