Doctor insights on:
Will Prograf Affect Creatinine Level
My doctor told me my creatinine level is too high and we should decrease the Prograf dose. What problem can a high creatine level cause?
Creatinine elevation: Creatinine, produced by muscle cells, is not toxic. The level in blood is a marker of kidney function. Increased level usually indicates reduced kidney function. Prograf is an extremely important medication for transplant patients to prevent immune rejection but can cause toxicity to kidneys. The dose has to be adjusted within a very narrow range to try to prevent both rejection and kidney injury. ...Read more
Taking Prograf XL, 0.5 mg twice daily. Tacrolimus level <2 ng/ml (ref: 5-20 ng/ml). What can cause my tacrolimus to be below the desired range?
Drug levels: Other medications can affect the level of a medication, and sometimes there is lab error. Speak with your specialist who ordered the lab test to determine if repeat or follow up is necessary ...Read more
What are normal prograf levels for liver transplant patients and what ios the avg medication adjustment time, if any?
6-12: Talk to your transplant pharmacist. After a solid organ transplant you need conselling from a transplant pharmd. The level of tacrolimus is not the only criteria to be concerned about. They will talk to you about interactions between medications and how frequent to expect any medical changes. Your team of surgeon, hepatologist, pharmd and psychologist will all help as well as your nurse practi. ...Read more
I have an organ transplant and take marinol, but it is unpredictably absorbed. Is it safe to sub an extract from high thc, low cbd natural cannabis? Will cbd significantly affect prograf levels?
Two types: First those related to immunosuppression. It affects t cell immunity so you can get viruses (like CMV and ebv) and rarely lymphoma. Second idiosyncratic side effects including elevated creatinine, high blood pressure and high potassium. Seizures, tremor. Hair loss. Despite all of these side effects, one of the best drugs for transplant patients. Can be used very safely. ...Read more
Nephrotoxicity: Most concerning long-term adverse effect of Program (tacrolimus) is nephrotoxicity (damage to the kidneys). The drug has a narrow therapeutic index and therefore the blood level of the drug is often monitored to avoid side effects. Other known side effects include tremor, elevated blood pressure, elevated blood glucose, and hair loss. ...Read more
Wich is better in general, prograf or cyclosporin? For the kidney, I really want the best for my kidney and my health, please?
Tacrolimus (Prograf): Approximately >90% of kidney transplant programs in the U.S. use tacrolimus-based maintenance immunosuppressive regimen. In many kidney transplant programs, 1-year acute rejection rate is ...Read more
Immunosuppressant: Prograf is a powerful immune system suppressant used to prevent rejection of transplanted organs, mostly kidneys and hearts. It's use can result in a multitude of complications and thus patients using it are closely monitored. ...Read more
Autoimmune suppressi: Tacrolimus or Prograf or Advagraf is an immunosuppressive drug used mainly in organ transplant to reduce organ rejection. It has also been useful in atopic eczema and in severe uveitis (Inflammation of the colored portion of the eye) Side effects can be severe. Patient must be under specialty care throughout the treatment. Topical use can cause irritation and burning sensation used for eczema ...Read more
Prograf (tacrolimus): Is a prescription medicine that can help to prevent rejection of kidney, liver, or heart transplants. I would be very wary of any internet company that would sell it without a prescription. ...Read more
Depends: Tacrolimus (Program) is a immunosuppressive drug that has a narrow therapeutic index. Once you are started on the medication, you will need to get your levels checked until they are in the target range and then at least once a month. ...Read more
Skin cancer: Prograf suppresses the immune system and does make one more prone to skin cancer. Since the vast majority of skin cancers remain localized, one need not worry about rapid spread. It is a very good idea to practice good sun sense if you are immunosuppressed. This would include coverup clothing and sunscreens when outdoors. ...Read more
Widely since 1994: Prograf or tacrolimus or fk-506 is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a japanese soil sample that contained the bacteria streptomyces tsukubaensis. It was approved by the fda as an immunosuppressant for liver transplanation in 1994 and is now approved for all solid organ transplants. ...Read more
Active investigation: The short answer is for as long as you keep the graft. However, there are ongoing trials that look to minimize the dose or eliminate tacrolimus by substitution with other agents. The reason is this drug is in a class called calcineurin inhibitor agents that may result in chronic scarring and loss of kidney function over time. You should discuss this with your transplant team. ...Read more
What can happen to someone on immunosuppressants like prograf, if hanging around someone with the flu?
Could be affected: Your immune system is not as strong while using prograf, so be careful and use social distancing if around someone with the flu. Hand washing after contsact is especially important. ...Read more
Yes: This is listed as an infrequent side effect. ...Read more
Herbal unknown: Many drugs can interfere with immunosuppressive drugs metabolism and levels. Moringa oleifera is a nutritional supplement that is most like a multivitamin of sorts although it contains a large amount of potassium and phosphorus and protein. It would not be advised to take if someone has chronic kidney disease. It's effects on immunosuppressive medication is not clearly known. ...Read more
I use total 6 mg prograf for a day. My hands are trembling. Is this temporary? Can I drive a car again?
Tremor is common: You need to discuss this with you physician. The dose may need to be adjusted but there has to be caution since you did not says but the reason you are on it needs to included in the consideration ...Read more
Has anyone here taken prograf or cellcept (mycophenolate mofetil) and noticed any increase in blood sugar?
What can happen if my friend misses 4 doses of prograf for 1yr old kidney transplant? He has never missed a dose until now.
Not much: Always good to keep to the medical schedule your doctor gave you. But missing 4 doses, as long as you pick up again with the proper dosing schedule, is unlikely to cause any problem. ...Read more
I have resistant refractory cutaneous dermatomyositis. I've tried all the traditional as well as ivig and rituxan (rituximab) have failed. What is prograf?
Cyclosporine or Prograf, which one is more convenient or less aggressive for a patient with ckd stage 3 and less unpleasant side effects?
Whoa!: Both of these are immunosuppressive agents. Their indications vary depending on what is actually wrong with the kidney -- clinical diagnosis and biopsy, perhaps current. These are often used in patients who have had transplants. Please do not attempt to self-administer any of these medications as they are quite dangerous. Stage 3 CKD may not require any medications. ...Read more
Not specifically but: Not specifically from the use of Prograf (tacrolimus), but it might be possible that immune suppression could leave you more vulnerable to infection generally, so really careful hygiene is important, as well as regular dental checkups. ...Read more
Is there a link/connection between Mitral Valve Prolapse and Sjogren's Syndrome? Increase risk if I'm on Prograf (Tacrolimus)?
Trying to figure out how to manage low RBC and WBC counts...wanting to know how best to treat this while on Prograf, Prednisone and Cellcept (mycophenolate mofetil).
Don't do it: Those blood count changes are most likely due to your medications. They not require treatment. Your medications can cause bone marrow suppression which will cause these blood counts to decrease. The medications are normally adjusted based on these counts and the function of the transplanted organ they are protecting. Do not try to adjust these meds or blood counts without your docs directions. ...Read more
What are the pros and cons for Prograf vs Prednisone vs plaquinil for the treatment of Undifferentiated connective tissue disease (elements sle)?
Connective tissue dz: Prograf is potent immune suppression. It is reserved for progressive well defined disease. It has side effects such as infection, nerve irritation, lipid elevations, and potential kidney injury. Blood levels must be measured. Prednisone is a traditional anti-inflammatory drug that works well but has side effects too. Plaquenil (hydroxychloroquine) is used widely to control disease. Eyes must be examined every 3 mo ...Read more
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