Doctor insights on:
Will Primary Sclerosing Cholangitis Kill Me
Primary sclerosing cholangitis (psc) is a chronic liver disease caused by progressive inflammation and scarring of the bile ducts of the liver. The inflammation impedes the flow of bile to the gut, which can ultimately lead to liver cirrhosis, liver failure and liver cancer. The underlying cause of the inflammation is ...Read more
Difficult problem: Psc: autoimmune swelling/scarring of bile ducts within and outside the liver; often associated with infl. Bowel (usually ulc colitis). Increased risk for biliary ca. Med rx for itch, biochem abnormalities, e.g. Urso (bear bile), antihistamines, antibiotics for infections, vitamin supllements for deficiencies. Ercp procedure may open some strictures (narrowing). Ultimately, may need liver transpla. ...Read more
PSC: Primary sclerosing cholangitis (psc) is a chronic liver disease caused by progressive inflammation and scarring of the bile ducts of the liver. The inflammation impedes the flow of bile to the gut, which can ultimately lead to liver cirrhosis, liver failure and liver cancer. The underlying cause of the inflammation is believed to be autoimmunity. ...Read more
Depends: Primary sclerosing cholangitis (psc) causes destruction of the bile ducts inside and outside of the liver. The first symptoms of the disease include fatigue, itching and jaundice, or yellowing of the skin and eyes. Psc however, is associated with a number of hepatobilliary disorders like pancreatitis, which may cause pain. ...Read more
I'm a 25 year old male recently diagnosed with stage 2 primary sclerosing cholangitis. Is this a common age range for this issue?
Sorry to hear: Primary sclerosing cholangitis tends to occur more frequently in males than women and onset may be between 20-30yrs old. Sometimes it is isolated, other times it may be associated with other diseases such as ulcerative colitis. Hopefully, you are seeing a hepatologist at a local university hospital, who can discuss possible treatments w/ you. Stay positive and god carry and bless you! ...Read more
Depends: On stage. Usually it has poor response to chronic meds, and antibiotics are used for superimposed infections in times of flare ups. ...Read more
Yes: The goal of managing acute attacks is antibiotics and IV fluids. In about 15%, emergency decompression or surgery is needed. Prevention of future attacks of cholangitis is based on removing biliary stones and debris, dilation or resection of strictures, and establishing optimal biliary drainage. Also important to rule out the clonorchis parasite. Your GI doctor can discuss newest treatments. ...Read more
Bile duct scarring: Primary sclerosing cholangitis (psc) is an inflammatory disease of the bile ducts that causes scarring and subsequent obstruction of bile ducts inside and/or outside the liver. This blocks the flow of bile to the gut, which can ultimately lead to cirrhosis of the liver. The underlying cause of psc is not entirely known, but believed to be an auto-immune disorder with a strong association with uc. ...Read more
It can.: Primary sclerosing cholangitis (= psc, inflammation of bile ducts) can give symptoms such as itching, pain in the right upper abdomen, fevers, chills, night sweats, and jaundice (yellow skin, yellow whites of the eyes). Most people with this illness have ulcerative colitis, which has symptoms of its own (eg. Bloody diarrhea, abdominal pain). Many with psc eventually need liver transplant. ...Read more
Any information and/or prognosis for Primary Sclerosing Cholangitis, from which I am currently dying?
No: Primary sclerosing cholangitis is a rare disease affecting 6 out of 100, 000 people in the USA. It is more common in men then in women, and the mean age at diagnosis of is around 40 years of age. ...Read more
Yes: Yes there is an association. See this link: http://www. Mayoclinic. Com/health/primary-sclerosing-cholangitis/ds00918/dsection=risk-factors. ...Read more
Which tests can I undergo to give me a good overall idea of my health, as well as check for Primary Sclerosing Cholangitis (runs in family)?
Ans: You need to go to your doctor for your physical exam. This will include a good history of yourself and family he. You will then be examined and based upon all of the above your doctor will order appropriate lab work for you ...Read more
Is primary sclerosing cholangitis only associated with severe Ulcerative Colitis? Or is it associated with mild disease too?
With all UC: It is associated with UC regardless of how bad it is. That being said, you don't need to have UC to get PSC. ...Read more
Does primary sclerosing cholangitis show up in blood work? I'm itching all over my body. What can I do?
Similar symptoms: Distinct diseases that announce themselves in the same way. Both destroy the small bile ducts within the liver and produce jaundice, itching and sometimes failure of the liver. The microscopic picture, labs, and treatment options are as strikingly different as the presentations are similar. ...Read more
I have a 16 year old female friend with primary sclerosing cholangitis. If she is on the liver transplant list, what is her prognosis?
Depends on donors: Placement on the national wait list for a deceased donor liver means that she is not expected to survive without transplantation. Her life will depend on the generosity of others who agree to donate their organs. Unfortunately there is a severe shortage with 18 deaths per day in the us. Her outlook is bright if she does get a liver in time. ...Read more
PSC is progressive: You do not state whether your sclerosing cholangitis (sc) is primary or secondary, primary sc is an autoimmune disorder where the bile ducts become inflamed, leading to blockage of bile flow leading to liver damage. Secondary sc is due to other type of bile duct injury, but blockage leads to liver damage. Psc is progressive, ssc can only be treated if the blockage is relieved. See a hematologist. ...Read more
Gastroenterologist: Your regular doctor can make the initial diagnosis but you probably want to be followed by a gastroenterologist. ...Read more
Not fusiform: It causes strictures and shrinking of the bilary tree. ...Read more
Management of SC: The goal of managing acute attacks is antibiotics and IV fluids. In about 15%, emergency decompression or surgery is needed. Prevention of future attacks of cholangitis is based on removing biliary stones and debris, dilation or resection of strictures, and establishing optimal biliary drainage. Also important to rule out the clonorchis parasite. Your GI doctor can discuss newest treatments. ...Read more
It is an infection of the bile ducts. Usually there is an obstruction of the bile ducts. Most commonly this is caused by a gallstone, although there are other rarer causes. It can be life threatening. If you have pain in your right upper quadrant, a fever and are jaundiced, ...Read more