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Doctor insights on: Will My Baby Have Sickle Cell Disease If My Partner And I Carry The Gene

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Will my baby have sickle cell disease if my partner and I carry the gene?

Will my baby have sickle cell disease if my partner and I carry the gene?

Not necessarily: If you and your partner both have sickle cell trait, there is a 25% chance your child will be normal (not have sickle cell trait or anemia), a 50% chance they will have sickle cell trait (just like you and your partner), and a 25% chance they will have sickle cell disease. Prenatal diagnosis is available early in pregnancy that will tell you what your child has. ...Read more

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


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Can genetic testing for sickle cell disease be done before birth of baby?

Can genetic testing for sickle cell disease be done before birth of baby?

Genetic test Sickle: Yes the test is done on high risk women at the 17 week of gestation by doing amniocentesis with the permission of both patents. ...Read more

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What's the rate of occurrence of sickle cell disease (gene frequency, and mutation rate)?

What's the rate of occurrence of sickle cell disease (gene frequency, and mutation rate)?

Sickle: What is the rate of occurrence for the disease sickle cell anemia or disease?" -- the occurrence rate is 25% if both parents are carriers, 50% if one parent has it and another parent is a carrier and 100% if both parents have it. Roughly 1, 000 infants are born, in the U.S., with it each year. ...Read more

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Which is the rate of occurrence of sickle cell disease( gene frequency, and mutation rate)?

Which is the rate of occurrence of sickle cell disease( gene frequency, and mutation rate)?

Depends on geography: Given the single base change responsible for sickle cell trait in the beta globin gene, the frequency of new mutations is essentially zero. According to the cdc in the usa, 8-10% of african americans have sickle cell trait and 0.2% have sickle cell disease. Conversely, in western africa, the prevalence of sickle cell trait is 30-40%. ...Read more

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If I have the gene for sickle cell disease, is it possible to not get the actual disease?

If I have the gene for sickle cell disease, is it possible to not get the actual disease?

Yes: One copy of the beta-globin gene mutation causing sickle hemoglobin is called sickle trait--the other normal copy (most genes are paired) makes sufficient normal globin to prevent disease. If you as a person with sickle trait (carrier of sickle cell disease) marry someone with sickle trait, then you have a 25% chance to have a child with sickle cell disease with each pregnancy. ...Read more

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Is sickle cell anemia purely a genetic disorder?

Is sickle cell anemia purely a genetic disorder?

I Don't Think So: I'm guessing a bit as to what you mean by your question. Sickle cell anemia is caused by a gene mutation on both copies of the beta globin gene. In that sense it is a genetic disease. However, a number of other factors, some of them environmental, can influence the type and severity of problems that patients with ssa have. ...Read more

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What type of genetic disorder is sickle cell anemia or trait?

What type of genetic disorder is sickle cell anemia or trait?

Hemoglobinopathy: Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing part (heme). Patients with ssa inherit an abnormal beta-globin gene from each parent. Carriers have one normal beta-globin gene and one sickle beta globin gene. The carriers (trait) have no symptoms. ...Read more

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How does a genetic mutation cause sickle-cell disease?

How does a genetic mutation cause sickle-cell disease?

Important gene...: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease. ...Read more

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Is sickle cell disease genetic?

Is sickle cell disease genetic?

Yes: The recessive sickle gene is carried silently in a percentage of the population.When two carriers produce offspring their is 25% risk with each conception that an affected baby will be born. ...Read more

Dr. James Ball
348 doctors shared insights

Sickle Cell Disease (Definition)

This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more


Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their ...Read more