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Doctor insights on: Will Methotrexate Make Me Gain Weight

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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Dignosed RA lastyear, prescribed methotrexate for 1 year. But stopped taking them after 10months. No pain now, gained lot weight, what can be reason?

Dignosed RA lastyear, prescribed methotrexate for 1 year. But stopped taking them after 10months. No pain now, gained lot weight, what can be reason?

Methotrexate does No: Your weight gain can not be attributed to Methotrexate. It is due to excessive eating, so it could be from other reasons. One other medicine causing weight gain are steroids which are sometimes used for the treatment of RA. Are you sure you are not taking Prednisone or another similar steroid?? Check and let me know? ...Read more

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Methotrexate for sjogrens disease does this treatment cause weight gain?

Methotrexate for sjogrens disease does this treatment cause weight gain?

Typically not: Weight gain is not a typical side effect of methotrexate. When it occurs in sjögren's, I would look at other rx being used such as steroids as a possible cause. Also, with any chronic disease, if the patient doesn't feel well, there is often a reduction in overall activity which leads to weight gain. ...Read more

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What to expect while on methotrexate for lupus? Lots of nausea that day? Also, I heart it causes fatigue at first? Any weight gain?

What to expect while on methotrexate for lupus? Lots of nausea that day? Also, I heart it causes fatigue at first? Any weight gain?

Some: No weight gain with Methotrexate but nausea and fatigue can occur in a minority of patients. If they do occur, tell your doctor as the symptoms might be timing or dose related and adjustments can be made. Do not be discouraged. Your doctor is thinking of medicines to aggressively control your condition. ...Read more

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Child gained 24pounds since started methotrexate 16 months ago she was average and now really chunky eating habits same is this normal side effect?

Child gained 24pounds since started methotrexate 16 months ago she was average and now really chunky eating habits same is this normal side effect?

See Your Doctor Now: Neither your child's age nor reason for taking Methotrexate is known however weight loss is usually seen. It is apparent your child's illness is serious & chronic based on the need for Methotrexate which can cause liver/kidney toxicity & lead to fluid retention/weight gain. Your child's diet/activity level must also be evaluated. See your doctor now for thorough exam & referral to Nutritionist. ...Read more

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I am taking methotrexate 2.5 every week (4pills)and primrose oil to treat psoriasis arthritis, been treating for 40 days, why did I lost weight?

Side effect: One of the common side effects of Methotrexate is loss of appetite and can cause unintentional weight loss. Primrose oil has been used in alternative medicine as an aid in treating psoriasis and should not be substituted for the western medications.
The mechanism of primrose oil is not completely understood, therefore, more study needs to be done. ...Read more

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Can methotrexate make you sick?

Can methotrexate make you sick?

Methotrexate: The side effects of Methotrexate include liver dysfunction, increased risk of infection, blood count abnormalities, fatigue on the day of treatment and gastrointestinal distress. ...Read more

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How well does methotrexate work?

Need more info: Methrotrexate is used for many diseases. Please ask this question again and be specific about what the Methotrexate is being used for. ...Read more

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Is it o.K. To tan while on methotrexate?

No: While this is actually unlikely to cause problems, sunburn may be more likely while using methotrexate. Though it may depend on why and how you're using it. ...Read more

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What are signs of methotrexate intoxicty?

What are signs of methotrexate intoxicty?

Many: Methotrexate toxicity can take many forms, from extreme mucositis, low blood counts, and kidney damage. If Methotrexate is given intrathecally (into spinal csf) as is done to treat leukemia, it can sometimes cause toxicity to the brain, which can manifest itself as seizures. Methotrexate can also affect the liver and lungs. If you are having new symptoms, talk with the prescribing doctor. ...Read more

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Please describe the medication: methotrexate?

Standard therapy: Methotrexate was originally used in the early 1950s as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA and other rheumatologist diseases. ...Read more

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Dr. Robert Lowe
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Rheumatrex (Definition)

Rheumatrex ...Read more