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Doctor insights on: Why Is Zoloft So Bad For The Kidneys

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Why is Zoloft (sertraline) so bad for the kidneys?

Why is Zoloft (sertraline) so bad for the kidneys?

No direct toxicity: Zoloft (sertraline) is primarily metabolized by the liver and there is no direct toxicity reported. ...Read more

Kidney (Definition)

The kidneys are paired organs that lie on either side of the vertebral column. Part of their critical functions include the excretion of urine and removal of nitrogenous wastes products from the blood. They regulate acid-base, electrolyte, fluid balance and blood pressure. Through hormonal signals, the kidneys control the ...Read more


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Does Zoloft have bad side affects long term? Like kidney, heart, liver disease?

Does Zoloft have bad side affects long term? Like kidney, heart, liver disease?

Few side effects: Zoloft (sertraline) is an antidpressant SSRI that rarely can lead to inflammation of the liver or other allergic reactions. Main side effect occurs with sudden withdrawal (reduce dosage gradually) or the so-called "serotonin syndrome" if taken with other drugs that increase the likelihood of this side effect. ...Read more

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Can you get kidney failure from overdosing on your zoloft (sertraline)?

Can you get kidney failure from overdosing on your zoloft (sertraline)?

I've not heard of it: It is difficult to kill yourself with most of the newer antidepressants. Many who make suicide attempts take a combination of meds and some organ damage might occur. If you or someone is considering overdosing, please seek help. Suicidal gestures or intentions are not the answer. They are many resources, call local help lines. ...Read more

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Can you drink green tea when u take Zoloft (sertraline) and have cystic kidneys?

Can you drink green tea when u take Zoloft (sertraline) and have cystic kidneys?

Zoloft (sertraline) + green tea: I am only responding from a psychiatric perspective. Green tea is fine with use of zoloft (sertraline). You will need to get input from a urologist or other physician about use of green tea with cystic kidneys. ...Read more

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Is Zoloft (sertraline) bad for my liver?

Is Zoloft (sertraline) bad for my liver?

Probably Not: Although metabolized by the liver, zoloft (sertraline) is one of the milder antidepressants on the liver. If you are very concerned you can ask your doc to check your liver enzymes. ...Read more

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Does Zoloft (sertraline) interact with alcohol badly?

Does Zoloft (sertraline) interact with alcohol badly?

Yes it does: You should not drink alcohol while taking antidepressants such as zoloft (sertraline). But don't stop spliff so you can drink - just don't drink. ...Read more

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Are diphenhydramine and Zoloft (sertraline) bad to take together?

Are diphenhydramine and Zoloft (sertraline) bad to take together?

OK but Caution: Benadryl (diphenhydramine) together with sertraline may increase side effects such as dizziness, drowsiness, & difficulty concentrating. Some people may also experience some impairment in thinking & judgment. You should avoid/limit use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. Max Benadryl (diphenhydramine) dose is 300mg/d. ...Read more

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Can't Zoloft (sertraline) make u sweat very badly even at night and resemble lymphoma sweats?

Can't Zoloft (sertraline) make u sweat very badly even at night and resemble lymphoma sweats?

Zoloft (sertraline) sweats: The whole class of ssri medications (including prozac, zoloft, paxil, (paroxetine) etc.) can cause night sweats, particularly as you are stopping or reducing the medication. Paxil (paroxetine) is the worst offender in this group. Some patients have this symptom even while taking the medication. Usually it will go away after a few weeks. ...Read more

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How long does SSRI discontinuation symptoms last? Stopped cold turkey (bad I know) fromm Zoloft (sertraline) 200mg once a day??

How long does SSRI discontinuation symptoms last? Stopped cold turkey (bad I know) fromm Zoloft (sertraline) 200mg once a day??

Abrupt stopping meds: It is never wise to stop a medication abruptly. Side effects and discontinuation symptoms (drug company buzz for withdrawal symptoms) are always present. Should be done under your physician's supervision and should be tapered off and not abrupt ...Read more

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Does Zoloft help with social anxiety/increase confidence? I've been prescribed it for gen. Anxiety but my social anxiety is really bad.

Does Zoloft help with social anxiety/increase confidence? I've been prescribed it for gen. Anxiety but my social anxiety is really bad.

Social anxiety: Please consider getting some therapy from a clinical psychologist. Cognitive Behavioral Therapy is one effective approach. It's focused on the here-and-now and you do some at home exercised w/your "self talk" that can empower you. Peace and good health. Please remember that others are human also and have their share of anxiety to deal with also. It's not just you. ...Read more

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Want to take 50mg zoloft (sertraline) again but I love strawberry margaritas. It's a low does would drinking on it really be that bad? Would I black out?

Want to take 50mg zoloft (sertraline) again but I love strawberry margaritas. It's a low does would drinking on it really be that bad? Would I black out?

SSRI & ETOH.: See that you also use vyvanse (lisdexamfetamine) and Ativan. Use of alcohol is contraindicated with Zoloft, vyvanse (lisdexamfetamine) and Ativan. I can't say if you would black out or not - but why play with fire? ...Read more

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Bad reaction with Zoloft (sertraline) weaned down to 12.5 nine days ago side effects were present 4 days after should I half it again or wait another week?

Bad reaction with Zoloft (sertraline) weaned down to 12.5 nine days ago side effects were present 4 days after should I half it again or wait another week?

Zoloft (sertraline): It is really important that you wean off medications under the supervision of the doctor who prescribed it. I have not dropped to a dose lower than 12.5 mg w patients - but it depends on your providers' directives. ...Read more

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I stopped taking my Zoloft (sertraline) 3 weeks ago, the withdrawal symptoms were bad so I went back on tonight and I feel real sick. Not sure if It's a concern?

What dose?: Sick in what way? If you were on a relatively high dose you may want to gradually get back up to that dose after being off completely for that long ...Read more

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I have read such scary horrible things about people starting Zoloft (sertraline) and that the first few weeks are bad effects. Dizziness? So worried only on day 2

I have read such scary horrible things about people starting Zoloft (sertraline) and that the first few weeks are bad effects. Dizziness? So worried only on day 2

Depression: I have many patients who have taken zoloft (sertraline) without any serious side effects. Talk to your doctor about your concerns as he or she may ease your concerns. Best wishes. ...Read more

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I've always blushed badly in social situations and for 5yrs been on Zoloft (sertraline) which seemed to help at first but now seems worse than ever. What can I do?

I've always blushed badly in social situations and for 5yrs been on Zoloft (sertraline) which seemed to help at first but now seems worse than ever. What can I do?

Behavioral treatment: Medication can only help so much. There are various treatments that can help with social anxiety, such as cbt, energy psychology, emdr, and other exposure and desensitization approaches. Treatment can also involve targeting the beliefs that interfer with social functioning, such as feeling that you're not good enough or that you are in someway flawed. ...Read more

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Dr. Pappas! So are you saying Zoloft (sertraline) causes dizziness in less than 10% of people or more than 10% of people? And is it really bad dizziness? Spinning?

Dr. Pappas! So are you saying Zoloft (sertraline) causes dizziness in less than 10% of people or more than 10% of people? And is it really bad dizziness? Spinning?

Zoloft (sertraline): Pre-marketing studies of zoloft (sertraline) (another source) showed 12% of people had "dizziness" (not characterized further as "vertigo" or "spinning, " etc). The source I first quoted said more than 10%, which is close to this 12% figure. These figures would also leave ~90% of people who did not experience dizziness. If ~12% of patients in pre-marketing studies had dizziness, 88% did not. Big majority. ...Read more

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Does Zoloft (sertraline) give a bad taste?

Does Zoloft (sertraline) give a bad taste?

Dry Mouth Is Cause: Zoloft (sertraline) and most all antidepressants can cause dry mouth as a side effect. Without proper oral hygiene, one may experience a bad taste. Zoloft (sertraline) can inhibit the production of saliva, thus the dry mouth. The natural tendency to drink water can dry the mouth out further. Suck on a sugar-free hard candy or chew sugar-free gum to stimulate mucous production. Use a special otc mouthwash for dry mouth. ...Read more

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Can mixing Zoloft (sertraline) and pexeva be bad for u?

Can mixing Zoloft (sertraline) and pexeva be bad for u?

Pexeva and zoloft (sertraline): The drugs that you are mentioning are of the same category called selective serotonin reuptake inhibitor. Although it is not usual to prescribe at the same time each practitioner uses clinical judgement to treat. Often such combinations can usually mean various things such as the patient is not responding, the wrong diagnosis is possible or the patient may be having another medical issue. ...Read more

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Is having 2 beers on Zoloft (sertraline) really THAT bad for you?

Dangerous Combo: Zoloft (sertraline) + alcohol can = impaired cognition/ judgment, dizziness & sedation. See that you take ativan too. Ativan + alcohol = big No No! ...Read more

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Is it bad to take Zoloft (sertraline) and duromine at the same time?

Is it bad to take Zoloft (sertraline) and duromine at the same time?

Co-administration of: Phentermine & ssri's (e.g., zoloft) is not tecommended, per the pdr & other sources. ...Read more

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I am scared to take medication (zoloft). What are some of the bad side effects?

I am scared to take medication (zoloft). What are some of the bad side effects?

Sedation: There are many possible side effects although they are usually relatively mild. The more common would include sedation, increased yawning, decreased energy, changes in concentration, nausea, diarrhea, weight gain and increased sweating. Not everyone gets these side effects and some get very little in the way of side effects. I would talk with the prescribing physician about your concerns! ...Read more

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I'm currently on 100 mg of Zoloft (sertraline) daily and I have a bad cold. What can I take?

Meds aren't needed: For a cold. Cold Tips: For sore throat – gargle with warm salt water (1/2 tsp salt in 8 oz of water). * For congestion – saline nose drops or a neti pot. *For anti-inflammatory effect & mobilizing mucus- homemade chicken noodle soup.**For hydration- lots of water. Try clear broth. * Add honey & a small amt. Of lemon juice to Chamomile tea. ...Read more

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When do side effects start to kick in when you first start Zoloft (sertraline) 25 mg? Bad side effects. I no good ones take weeks.

Very low dose!: Although possible I wonder if what you are experiencing is do to zoloft (sertraline) at all. However, how much Acetaminophen and ibuprophen are you taking/day? Aceta can cause liver damage and ibup kidney and mixed together one has to be more vigilant. Have you had liver and kidney blood work done recently and a urinalysis? Discuss w/fmd. Immediate onset after one dose possible if allergic but usually w/rash. ...Read more

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Would side effects be present with increasing Zoloft (sertraline) dosage of 25 to 50mg? Although no bad side effects when taking 25mg, but many with 50mg.

Maybe: In my practice, I start most adults on zoloft (sertraline) at 50 mgs daily, and they do well. I then have them increase the dose to 100 - 200 mgs gradually, so they can be at a therapeutic dose.
If you are having side effects now, see your physician and discuss all of your medications, over the counter medicines, and concerns. It may be that your side effects are due to medication interactions. ...Read more

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Is it super bad if I accidentally took 2 doses of my Zoloft (sertraline) (12.5mg) one morning? Also, if I missed a dose, will I be okay? What will happen!? Scared

At this dosage: You should be ok. But, find a system to help you consistently remember to take your medications at the same time every day. I take mine in the morning before breakfast. It quickly became a habit ; now has become easy to remember. ...Read more

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Worrying about all bad things that could happen is making me sick. Scared & filled w/anxiety. What 2 do? Help please? Just started zoloft (sertraline).Could it help?

Worrying about all bad things that could happen is making me sick. Scared & filled w/anxiety. What 2 do? Help please? Just started zoloft (sertraline).Could it help?

Yes: And it may be even more likely to help if you support it with some talk therapy to help you find a way to correct the thinking and perhaps behavioral tendencies that can cause emotional distress. Ret or other cbt therapists are very beneficial for clarifying such patterns. It may even be possible to get beyond medication as you succeed. Good luck in your efforts. ...Read more

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I usually have a generic brand Zoloft (sertraline) but recently was given the original and am now experiencing bad side effects. Is it possible they work different?

Action same: The action is the same but the blood levels may vary by up to 20% in either direction between the brand name and the generic. ...Read more

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Can Zoloft (sertraline) cause discoloration/bad taste on tongue?

Can Zoloft (sertraline) cause discoloration/bad taste on tongue?

Sertraline rx: Zoloft (sertraline) can dissolve on the tongue or back of tongue / throat and burn with a bad taste. If swallowed well and whole, Zoloft (sertraline) can lead to a serotonin surge, like other SSRI meds, and this surge includes nausea, perhaps reflux, and odd GI and CNS sensations ...Read more

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Can I safely take 400mgs of zoloft (sertraline). I'm currently taking 200 - 300 mgs daily. My depression varies and today its bad?

Please don't up your: Dose dependent on how you feel one day. It takes quite a while for serotonin levels to increase - so upping your dose for a day will not make symptoms better. 400 mg of zoloft (sertraline) is well above the recommended dosage. You need to discuss this with your psychiatrist/ physician. See that you drink socially - that is definitely contraindicated if you take zoloft (sertraline). ...Read more

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I'm on 100mg zoloft (sertraline). I don't feel depressed anymore unless its a bad day, but I still worry constantly. What can I do? .

See a psychiatrist: Though ssris like zoloft (sertraline) can help some with anxiety (in addition to depression), some anxiety doesn't respond. The options include (1) switching medication, (2) adding an anti-anxiety medication, (3) starting psychotherapy for anxiety/depression (e.g. Cbt), (4) or all of the above. I'd suggest getting a referral to psychiatry to discuss specifics of treatment options. ...Read more

Dr. Heidi Fowler
1,087 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


Dr. Heidi Fowler
1,042 Doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more