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Doctor insights on: Why Is My Depression Getting Worse When My Antidepressant Wears Off

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Why is my depression getting worse when my antidepressant wears off?

Why is my depression getting worse when my antidepressant wears off?

Poop out: True antidepressants don't wear off like a stimulant. Antidepressants can take weeks to take effect. Some people find they get benefit from the medication but it seems to "poop out" after several months. This seem to be related to need for an additional medication to balance out or could be symptom of bipolar disorder with cycling. I discuss this in my book. Psychiatry in technocolors. ...Read more

Dr. Pamela Pappas
4,484 doctors shared insights

Depression (Definition)

Depression is a mood disorder that can affect behavior and emotions. Symptoms of depression include feeling down most of the time, losing interest in previously enjoyable activities, increase or decrease in appetite or weight, sleeping more or less, becoming easily agitated or lethargic, feeling worthless, feeling guilty, having difficulty concentrating, thinking more about death and dying. Depression can sometimes result in suicidal thoughts and plans. In this case, emergent ...Read more


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If switching from one antidepressant to another, can depression get worse before it gets better.?

If switching from one antidepressant to another, can depression get worse before it gets better.?

That might happen.: When going down on one medication ; up on another - the change is not always seamless in regards to your depressive symptoms. This would be especially true if you need to stop one medication completely and be drug free for a while before starting the new medication. ...Read more

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Why do antidepressant amlitripline, n others cause water retetnion an worsening depression . dizziness, an ears ring ect. in some post menapause?

Why do antidepressant amlitripline, n others  cause water retetnion an worsening depression . dizziness, an ears ring ect. in some post menapause?

Senior Depression : Recent studies suggest that serotonin re-uptake Antidepressants do not work better than placebo in those over 50. Serotonin production is reduced in seniors. Antidepressant Drugs with multiple mechanisms of action (serotonin plus norepinephrine plus dopamine) may work better. Talk with your doctor soon if you are having any adverse reactions to any drugs. ...Read more

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I often feel guilty for being on antidepressants. I have a great life! is there anything I can do to help with the depression and get off meds?

I often feel guilty for being on antidepressants. I have a great life! is there anything I can do to help with the depression and get off meds?

Psychotherapy: I'm glad you have a great life, and i hope the medications have helped you. Have you also been in psychotherapy, not just taking medications? The 2 work better together. And the therapy can help you learn about possible patterns that are making depression more likely -- plus learn to deal with them and not do them. Eventually you may be able work with your physician to taper off the meds. ...Read more

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Is it a good idea to start antidepressants in order to help me get to the root cause... assuming it's not clinical depression?

No.: Antidepressants serve their purpose for people that have diagnoses that merit them, but they don't work like Tylenol, (acetaminophen) they take about 1 month to 3 months to really be effective and may take a long period of time to wean off of them. Stopping those medications suddenly can produce a dangerous withdrawal. ...Read more

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I just need to know if a low does antidepressant with Vyvanse (lisdexamfetamine) helps to not get the depression when you go off the Vyvanse (lisdexamfetamine) for weekends?

I just need to know if a low does antidepressant with Vyvanse (lisdexamfetamine) helps to not get the depression when you go off the Vyvanse (lisdexamfetamine) for weekends?

Off-label: This would be an off-label use of an antidepressant. Psychiatrists sometimes do use medications in off-label ways, depending on circumstances. Still, antidepressants used only on weekends would not likely help much, since they usually require consistent dosing for 4-6 weeks to show effect. ...Read more

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If I go to a doctor about depression, will I get both counseling and antidepressants?

Antidepressants: Most doctors or more likely to give anti-depressants because it is a quick and easy fix. Most anitdepressants focus on modulating serotonin. Unfortunately, the cause of depression can be something other tnan a serotonin issue. It could be a situational issue with a direct impact on your life. It could be a lack of function of the adrenal gland or it could be a hormonal imbalance. ...Read more

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Tell me if depression, or stress, or exhaustion, or antidepressants and stuff affect the type of erection you can get?

Tell me if depression, or stress, or exhaustion, or antidepressants and stuff affect the type of erection you can get?

They certainly: Can in some people. In addition, the medications for such conditions can also affect erectile function in some people. Penis' like to be attached to happy people. ...Read more

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What wil the doctor do when your antidepressant helps with your depression but makes anxiety worse?

What wil the doctor do when your antidepressant helps with your depression but makes anxiety worse?

Change or add-on: There are several common antidepressants that have been fda approved for both depression and anxiety. Ask you provider if the one you're taking has been proven to work for both. Make sure to give the medication at least a month to begin to work. Some antidepressants are more activating at the outset, but ease up when the antidepressant effect kicks in. ...Read more

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