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Doctor insights on: Why Is Cystic Fibrosis More Common In Caucasians

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Dr. Derrick Lonsdale Dr. Lonsdale
Preventive Medicine
69 years in practice
University of London, St Bartholomew's Hospital Medical College
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What are the common symptoms of having cystic fibrosis?

What are the common symptoms of having cystic fibrosis?

Cough + sputum: If above applies, kiss him/her on the skin. If you taste salt it might be cf. A simple sweat test will rule it in or out.

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Caucasian (Definition)

Caucasian, to most people, means a white person. But by the racial classification made in the 19th century, it ranged from people with light skin (no. Europe) to darker (parts of no. Africa & india). These people were felt to be originally from the caucases region of southeastern europe. At it's current core meaning, it is a white person, or ...Read more


Dr. William Walsh Dr. Walsh
Addiction Medicine
13 years in practice
Indiana University School of Medicine
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Dr. William Walsh Dr. Walsh
Addiction Medicine
13 years in practice
Indiana University School of Medicine
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Is there a common age to start showing signs of cystic fibrosis?

Is there a common age to start showing signs of cystic fibrosis?

Birth to teen years: The most common variant of CF is detected at birth or would appear shortly thereafter anyway. Most cases are caught by the teen years, but rarer forms show up as late as 30 or so.

Dr. James Ferguson Dr. Ferguson
Pediatrics
42 years in practice
University of Texas Medical Branch School of Medicine
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Why cystic fibrosis only affects the caucasian population and how the disease may have originated?

Why cystic fibrosis only affects the caucasian population and how the disease may have originated?

Not true: Cystic fibrosis is a metabolic disorder more common in caucasions by present in many populations. The incidence is 1/3500 caucasion, 1/17, 000 african american, 1/80, 000 native american. It arises in mutations in the cftr gene that regulates cellular transport of chloride.There are in excess of 700 known mutations recorded but most common is the delta 508.

Dr. Charles Gordon Dr. Gordon
Pediatrics - Adolescent Medicine
years in practice
Columbia University College of Physicians and Surgeons
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If no one in my family has cystic fibrosis like even my distant relatives and my dad is arabic and my mom is caucasian can I stil hav cystic fibrosis?

If no one in my family has cystic fibrosis like even my distant relatives and my dad is arabic and my mom is caucasian can I stil hav cystic fibrosis?

At your age very unl: Ikely. At birth in most if not all states a tiny blood sample is taken and analyzed for a number of inborn errors of metabolism including the gene which controls the transport of the chloride ion across your cell membranes which is the underlying defect in CF. Problems almost always show up very early and are usually checked with an iontopheresis test.

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Dr. Amrita Dosanjh Dr. Dosanjh
Pediatrics - Pulmonology
32 years in practice
UC San Diego School of Medicine
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Dr. David Lipkin Dr. Lipkin
Internal Medicine
48 years in practice
Howard University College of Medicine
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During my preconception visit my dr. Was really pushing genetic screening for before we start conceiving. We have no family history of genetic disorders and she said nothing stands out (other than cystic fibrosis since we are both Caucasian).?

During my preconception visit my dr. Was really pushing genetic screening for before we start conceiving. We have no family history of genetic disorders and she said nothing stands out (other than cystic fibrosis since we are both Caucasian).?

See below: In addition to screening for cystic fibrosis, Indications for screening include, AMONG OTHERS, any one of the following:**A known or suspected hereditary disease in the patient or a family member; **Presence of birth defects, chromosomal abnormality, intellectual disability, developmental delay in a parent, a child, or the child of a family member**Ashkenazi Jewish ethnicity

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Dr. Gerald Mandell Dr. Mandell
Nuclear Medicine
48 years in practice
Jefferson Medical College of Thomas Jefferson University
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How can cystic fibrosis affect p.I.E.S development?

How can cystic fibrosis affect p.I.E.S development?

Certainly: Cystic Fibrosis (CF) most common life-limiting genetic disorder of Caucasians, affecting approximately 30K people in the US. A, impacting mainly respiratory function. In recent years patients symptoms better controlled by genetic findings and better medications. Emotional & phys. Development depend on severity, time in hospital, complications. Morb. & mort. Factors afect emotional, cognitive behavior.

Dr. Michael H. T. Sia Dr. Sia
Pediatrics
27 years in practice
Case Western Reserve University School of Medicine
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Can someone be diagnose with cystic fibrosis in their 40's?

Can someone be diagnose with cystic fibrosis in their 40's?

As a carrier: Genetic carrier testing: more than 10 million americans are symptomless carriers of the defective CF gene. This blood test can help detect carriers, who could pass CF onto their children. To have cystic fibrosis, a child must inherit one copy of the defective CF gene from each parent.

Dr. HARRY OPSIMOS Dr. OPSIMOS
Pediatrics - Pulmonology
18 years in practice
St. George's University School of Medicine
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I have symptoms of cystic fibrosis. Is it possible to start show the symptoms in my 30's?

Yes: Yes it is possible. Presentation of cystic fibrosis varies greatly, and it is possible, depending on your specific mutation (and other factors) to present at a later age. In order to prevent late diagnoses, all states now have a newborn screen in place for cystic fibrosis.

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Dr. William Walsh Dr. Walsh
Addiction Medicine
13 years in practice
Indiana University School of Medicine
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I have family members with cystic fibrosis. Is it possible to start show the symptoms in my 20's?

I have family members with cystic fibrosis. Is it possible to start show the symptoms in my 20's?

Yes: However, usually an adult who is diagnosed so late has usually had chronic problems with cough and "pneumonias". That said I've diagnosed a new case in a 38 year old woman.

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Dr. Josephine Ruiz-Healy Dr. Ruiz-Healy
Pediatrics
35 years in practice
University of Anahuac School of Medicine
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What are the chances of a child getting cystic fibrosis among the different racial groups in the u.S.?

What are the chances of a child getting cystic fibrosis among the different racial groups in the u.S.?

Overall 1/3700: Acording to the CF foundation: the overall birth prevalence is 1/3700. It can occur in any race, however the greatest incidence is in caucasians of northern european descent, being 1/2500. The other major groups affected are hispanics 1/13500, african americans 1/15000. More than 10 million of us carry one part of the defective gene, but to have the disease you must have a copy from both parents.

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Dr. Gregory Hines Dr. Hines
Family Medicine
20 years in practice
Saba University School of Medicine (coursework from 1/1/02 to present)
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What is cystic fibrosis?

Genetic disorder: It is a genetic disorder characterized by abnormal sodium channels, which affect a great deal of problems including the respiratory and digestive systems. It is most commonly diagnosed in infants failing to gain appropriate weight, and in children who have multiple chronic infections.

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Dr. Judy Orton Dr. Orton
Pediatrics
31 years in practice
University of South Florida College of Medicine
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Can you die of cystic fibrosis?

Yes but: Yes but with early diagnosis and regular care and adherence to prescribed therapy by a pediatric pulmonologist the long term survival has improved greatly in the past two decades.

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David Escobar Dr. Escobar
Family Medicine
5 years in practice
Pacific Northwest University of Health Sciences
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What is cystic fibrosis exactly?

Inherited disease: Cystic fibrosis (CF) is an inherited disease that affects the cells lining the lungs, sinuses, intestines, spleen and liver. It prevents chloride ions from crossing the cell membranes properly. This can clog organ ducts. In the lungs, the extra mucus crushes the cilia and leads to more lung infections. Medications can help; in late-stage disease, lung transplantation may be life-saving.

David Escobar Dr. Escobar
Family Medicine
5 years in practice
Pacific Northwest University of Health Sciences
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What is risk of cystic fibrosis?

Depends on genes: The risk of acquiring cystic fibrosis (CF) depends on whether the parents of a child are carriers for the gene. It is estimated that about 1 in 20 americans are carriers of the CF gene. In order for a child to acquire the disease, both parents must be carriers. If both parents are carriers, there is then a 25% chance that the child will acquire the disease.

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Dr. David Krulak Dr. Krulak
Family Medicine
19 years in practice
Uniformed Services University of the Health Sciences F. Edward Hebert School of Medicine
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What exactly is cystic fibrosis?

Cystic fibrosis: CF is a genetic disease that from birth causes the body to produce a thick and sticky mucus. This mucus interferes with the ability to breath and digest food. It is life threatening, but with good management people can live into their 40s and beyond with it.

Dr. Karl Muench Dr. Muench
Clinical Genetics
57 years in practice
Washington University School of Medicine
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Can you die from cystic fibrosis?

Yes.: Although the complications of cystic fibrosis are treatable, and although the available treatments are helpful, the disorder shortens the normal life expectancy.

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Dr. Colton Bradshaw Dr. Bradshaw
Pediatrics
years in practice
Louisiana State University School of Medicine in Shreveport
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Cystic fibrosis, is it sexlinked?

Autosomal recessive.: Cystic fibrosis (CF) is not sex-linked, but autosomal recessive. That means both parents can be silent carriers--totally unaware--then each passes down this recessive (inactive) gene to their child. This child develops CF because both copies of the formerly inactive gene (1 from each parent) now have no genetic "brake" (normal dominant gene) to prevent the CF gene from expressing itself.

Dr. Michael Sparacino Dr. Sparacino
Family Medicine
33 years in practice
A. T. Still University Kirksville College of Osteopathic Medicine
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Dr. William Walsh
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Cystic Fibrosis (Definition)

A genetic disorder of the lungs and digestive tract. It causes recurrent lung infections and inhibits growth in patients and average life expectancy of patients with cystic fibrosis ...Read more