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Doctor insights on: Why Does The Depo Provera Shot Cause Weight Gain

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Dr. Michael Rothman
1,333 Doctors shared insights

Weight Gain (Definition)

Weight gain is an increase in body weight. This can be a result of increases to muscle mass, increases in body fat, or increases in body fluids like water. Occasionally, weight gain can be a symptom of ...Read more


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Is it possible Depo-Provera provera (medroxyprogesterone) to really cause weight gain?

Is it possible Depo-Provera provera (medroxyprogesterone) to really cause weight gain?

Yes: Studies are conflicting about this question and its sometimes officially denied. However; In my experience, many women gain weight on Depo Provera (medroxyprogesterone). ...Read more

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Was on Depo-Provera vera but gained over 50 lbs. I know everyone reacts differently. Is there another contraceptive that is less likely to cause weight gain?

Was on Depo-Provera vera but gained over 50 lbs. I know everyone reacts differently. Is there another contraceptive that is less likely to cause weight gain?

Oral contraceptives: Depo shot does make some pt gain weight, it is better to go back to your doctor to try different forms-there are oral contraceptives subdermal implant as well as patches that use every week. Or ring that can leave in for 3 weeks before remove. ...Read more

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If I want to stop the Depo-Provera shot due to weight gain, how long will the progesterone hormone be in my system?

If I want to stop the Depo-Provera shot due to weight gain, how long will the progesterone hormone be in my system?

Agree but: I agree completely with the first answer, but remember that normal menstruation/cycling may take much longer to resume: although it's unusual, cases of 1 year to even 2 years have been reported. ...Read more

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Thought coming off depo shot would do good now boobs triple size and hurt and no sex drive and weight gain! Maybe I should stay on it??

Thought coming off depo shot would do good now boobs triple size and hurt and no sex drive and weight gain! Maybe I should stay on it??

Depo effects: Depo provera is a progesterone only contraceptive product and is known for decreasing your sex drive and weight gain. The breast enhancement may be due to increasing estrogen production off of the depo medication depending upon how long you have been off of it. Talk to your GYN MD about this matter and see what can be done. ...Read more

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Taking depo shot & breast feeding but not gaining any weight. Just losing weight pretty fast. Any options on what to do to stop losing weight & gain?

Taking depo shot & breast feeding but not gaining any weight. Just losing weight pretty fast. Any options on what to do to stop losing weight & gain?

See nutritionist: You say you're breastfeeding. It is normal to loose some weight while doing that. I don't know your numbers but go see a nutritionist and she can guide you on your dietary intake. ...Read more

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I responded terribly to the Depo-Provera shot. Mood swings, breakthrough bleeding all 3 months, weight gain of 30lbs. Would implanon affect me the same way?

I responded terribly to the Depo-Provera shot. Mood swings, breakthrough bleeding all 3 months, weight gain of 30lbs. Would implanon affect me the same way?

It could: The Progesterone in Implanon is different than the Progesterone in Depo Provera (medroxyprogesterone) plus it is a lot lower dose. That means you are somewhat less likely to have the side effects you had with Depo-Provera provera. Remember that Implanon can give irregular periods, but is much less likely to bleed for 3 months, or to cause much weight gain, and less likely to give mood swings. ...Read more

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I'm on the Depo-Provera prevera shot and I haven't had a period and am having symtoms of pregnancy including weight gain I took a test n it showed faint line?

I'm on the Depo-Provera prevera shot and I haven't had a period and am having symtoms of pregnancy including weight gain I took a test n it showed faint line?

Repeat: Depo-provera is one of the most effective options. It can fail but failures are rare. If you're having symptoms then there shouldn't be a faint line. Try repeating the test tomorrow. ...Read more

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Weight gain, sore nipples, and at the end of my 3 months for my Depo-Provera shot...possible to be pregnant? I've been on the Depo-Provera for 2 1/2 years.

Weight gain, sore nipples, and at the end of my 3 months for my Depo-Provera shot...possible to be pregnant? I've been on the Depo-Provera for 2 1/2 years.

Yes, Possible: If you are having unprotected sex, pregnancy is possible regardless of your choice of contraception. Although Depo-Provera is an effective means of birth control, no method (pill, patch or condom) other than abstinence is 100% effective. As you may know, there are over-the-counter urine pregnancy tests available. I would suggest discussing this with your OB/GYN or the prescriber of your Depo. ...Read more

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I've been on the Depo-Provera shot a year. I've had mood swings and weight gain. Is there a diff. Birth control I can take that has less weight gain side effects?

Avoid depot: Medroxyprogesterone acetate (Depot Provera) stimulates the appetite center in the brain and via this mechanism can lead to weight gain in excess of 30 - 60 lbs. Birth control methods that contain ethinyl estradiol and a progestin, like birth control pills or the nuvaring, or intrauterine devices have a much better body weight profile. ...Read more

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Is natazia (estradiol valerate and dienogest) or Depo-Provera shot better for fibroid tumors and severe pain? How are they different and which one is worse with weight gain?

Is natazia (estradiol valerate and dienogest) or Depo-Provera shot better for fibroid tumors and severe pain? How are they different and which one is worse with weight gain?

If you have fibroid: Tumors causing severe pain, without knowing any details like how many, how large and where they are located you need depo-lupron or surgery or both please ask your gyn about these options. ...Read more

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Can allergy shots really cause weight gain?

Never studied: I am not aware of any clinical data on weight gain and immunotherapy. Antihistamines do stimulate appetite so that could be s confounder. Anecdotally I have not seen this phenomenon in my clinical practice. ...Read more

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Does ccortisone shots cause weight gain? If so, how much weight?

Does ccortisone shots cause weight gain? If so, how much weight?

Cortisone shots: Cortisone shots are done for a lot of reasons. A shot into a joint may relieve arthritis pain, at least temporarily. But cortisone has many side effects. Yes, you gain weight, but also shift fat to the midsection. You get Insulin resistant, which can lead to diabetes. It can weaken your bones: osteoporosis. Your body can tolerate an occasional shot, but this should not be done lightly. ...Read more

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Can the weight gain from Depo-Provera ever wear off?

Yes once: All of the Depo-Provera is out of yoru body it will be easier to lose the wt u will need caloric restriction and exercise, depending on how long you were on the Depo-Provera it can linger in your system for up to 6-9 months after the last injection. ...Read more

Dr. Cynthia Palabrica
932 Doctors shared insights

Depo Provera (Definition)

Depo-Provera is a progestin-based agent which is a kind of women's ...Read more