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Doctor insights on: Why Does A Positive Rf Referred Not Positive For Ra

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I got a weak positive ANA and negative rheumatoid factor. What does this mean?

I got a weak positive ANA and negative rheumatoid factor. What does this mean?

They don`t mean much: These tests are within normal limits and don`t mean much. Tests can be negative in the presence of disease and positive in normal people. Diagnoses depend on a competent physician who does a proper history and physical exam and uses tests and x-rays and others to arrive at a diagnosis. Don`t over depend on tests. ...Read more

Dr. Tracy Lovell
937 doctors shared insights

Rheumatoid Arthritis (Definition)

A chronic inflammatory disorder that affects joints and may also affect ...Read more


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What does a high positive ELISA but negative ANA mean for a Lupus Screening? How are they different and how can 1 be positive and one negative?

What does a high positive ELISA but negative ANA mean for a Lupus Screening? How are they different and how can 1 be positive and one negative?

ANA: 1. ELISA is an immunoassay used to screen for ANA (high sensitivity, relatively low specificity). Can have false positive even with high titer. 2.If ELISA positive, usually a confirmation test will follow. Indirect Fluorescent Antibody Assay (IFA) is more specific test used as a golden standard to detect ANA. Hope that helps. ...Read more

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I received blood test results with positive RNP and Ana not detected. Is it possible to not have SLE or mctd, or it's definite due to positive RNP?

Ritter: These tests are prone to lab error, and many healthies have one or both positive especially at low titer. These are only one piece of information that your physician will use. ...Read more

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I had a positive HLA B27, positive ANA, positive SM anitobody, and a positive RNP. and Raynauds, is this likely Lupus?

I had a positive HLA B27, positive ANA, positive SM anitobody, and a positive RNP. and Raynauds, is this likely Lupus?

Lupus is a clinical: Diagnosis, made based on the presence of physical symptoms and specific organ involvement and is not a diagnosis made by the presence of a genotype or auto antibody. What symptoms have you had that prompted your physician to do this series of tests? What is the opinion of the rheumatologist seeing you (or are you still awaiting a visit with rheum?) These disorders are complex/overlap. Talk w/ URMD ...Read more

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How often does an ANA test comeback positive when lupus is not involved? What else could a positive ANA indicate? (there are several symptoms of sle)

Positive ANA: A positive ANA can mean many things. Lupus is just one autoimmune disorder. An ANA can come back positive and be rechecked and be negative. There are other blood markers that we use to tell what an ANA means. Ask your doctor if other tests were done. ...Read more

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Does the blood test for RA have false negatives?

Does the blood test for RA have false negatives?

Clarify: Done correctly, the test simply tells whether rheumatoid factor is present in the blood. Around 25% of people with obvious rheumatoid arthritis never develop rheumatoid factor in the blood. Rheumatology has many labs but all are ancillary to the history and physical exam. As a pathologits -- "treat the person, not the numbers.". ...Read more

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I have seropositive rheumatoid arthritis/anti-ccp strongly positive. What the heck does that mean?

I have seropositive rheumatoid arthritis/anti-ccp strongly positive. What the heck does that mean?

Rheumatoid arthritis: What you describe supports the diagnosis of rheumatoid arthritis. It you are not already under the care of a physician, please see one asap as treatments can relive pain, deformity and forestall progress of disease. ...Read more

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A positive ANA test 1;320 titer, with a speckled pattern... Does it mean I have an autoimmune disease...

A positive ANA test 1;320 titer, with a speckled pattern... Does it mean I have an autoimmune disease...

Not necessarily: The ANA is a screening test for lupus but is not specific. It can be positive in numerous other diseases and in normal people. It has to be evaluated in the context of the clinical picture and the results of other autoantibody tests. ...Read more

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I have tested positive for ana and my rnp is 14.1 what does that mean?

I have tested positive for ana and my rnp is 14.1 what does that mean?

Here's helpful link: Anti-RNP antibodies are strongly associated with Mixed Connective Tissue Disease (MCTD), and the majority of patients diagnosed with MCTD test high positive for RNP antibodies. Ref: www.mollysfund.org/2014/06/mixed-connective-tissue-disease ...Read more

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Can a MCTD diagnosis always change? I tested positive for ANA and Rnp

Maybe: It will depend on how high the titers are and what signs / symptoms you have. Low titers may mean nothing at all. Without clinical evidence of multisystem disease, the diagnosis of MCTD is very, very unlikey ...Read more

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Tested negative for ankylosing spondylitis by PCR blood test. Apparently PCR is the most sensitive test. Does this mean i definitely don't have as?

Tested negative for ankylosing spondylitis by PCR blood test. Apparently PCR is the most sensitive test. Does this mean i definitely don't have as?

No blood test for AS: If you are referring to the hla-b27, this is not a diagnostic test. You can still have as but it is less likely. This is a conversation for your doctor, however. ...Read more

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What is considered a positive result for the SM antibody for SLE? My Ana 1:320 but DNA was negative. So many blood tests for SLE diagnosis!!

SLE: hi, diagnosis of SLE is not base on blood test, positive DsDNA and ANA are just one out of 11 criteria for diagnosis of SLE, to diagnose SLE you need to have 4 out of 11 criteria. ANA is a non- specific test and false positive rate is high, especially in women and elderly. ...Read more

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What does it mean to have a positive IgM but a negative IgG for mycoplasm?

What does it mean to have a positive IgM but a negative IgG for mycoplasm?

Early vs late: Igm is the immunoglobulin noted for coming out early in response to any illness, it fades over time while igg come out a bit later and stays up longer. If you have a positive IgM it indicates a early response, while igg would probably show up in a few months at which point the IgM would have declined. ...Read more

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If my blood tested positive for lupus what does that mean?

If my blood tested positive for lupus what does that mean?

Nothing: Lupus is diagnosed based on a combination of lab tests and symptoms. A lab test alone does not diagnose this disease and could be positive in many diseases as well as individuals who have no health problems. ...Read more

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What does a mildly positive rheumatoid factor test indicate if the doctor thinks you don't have arthritis?

What does a mildly positive rheumatoid factor test indicate if the doctor thinks you don't have arthritis?

There are nearly 5%: There are nearly 5% of the population with a positive rf, but only 1% has ra. Therefore 80% of rf that are positive are "false positives." most are very low in titer. A higher level of rf positivity is more significant, since level does correlate with higher disease activity in ra. Less common causes for rf positivity include sjogren's syndrome, sarcoid, and others, but these are much less common. ...Read more

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What does a mildly positive rheumatoid factor test indicate?

What does a mildly positive rheumatoid factor test indicate?

It depends: A rheumatoid factor (RF) is a non-specific result. It can be positive in Rheumatoid Arthritis and a variety of other conditions. Many have a positive RF and have no disease at all (false positive). What's most important is your symptoms. Certain patterns of joint pain, stiffness and fatigue can be related to rheumatoid arthritis for example. Then the positive RF is significant. ...Read more

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Positive ANA 1;320 speckled pattern and a negative ena... Does this mean i don't have lupus?

ANA: You really need to meet with a rheumatolgist to discuss this further since they might need further testing or biopsy to determine the answer. ...Read more

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Will a positive ANA necessairly mean lupus?

No: A positive ANA alone does not make one have lupus. Other criteria must be met to be labeled with lupus. ANA can often be false positives. ...Read more

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What does a weakly positive ANA with only rnp antibodies indicate?

Specific to patient: The test by itself is not diagnostic.. It depends on your evaluation, examination, clinical factors are the most pertinent. The lab reports are guidelines but not diagnostic in themselves. ...Read more

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I'm 23 male my ra factor is 100 positive my ccp is 16 negative , sed rate 12 negative, and crp .13 negative can high blood fats cause + ra factor?

I'm 23 male my ra factor is 100 positive my ccp is 16 negative , sed rate 12 negative, and crp .13 negative can high blood fats cause + ra factor?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, rheumatoid factor is not a specific marker for rheumatoid arthritis. It can be positive in many situations, including recovery from infection. High blood fat per se is not a cause of +RA factor. ...Read more

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My blood test for rfigm was 176 the normal range is 0-25. Would this indicate a positive RA result?

My blood test for rfigm was 176  the normal range is 0-25. Would this indicate a positive RA result?

Yes: False positives sometimes occur, but those are usually not this high. The blood test doesn't equal a diagnosis of rheumatoid arthritis all by itself, but if you have painful, stiff, swollen joints, that is the most likely diagnosis. See a rheumatologist - the sooner the better. ...Read more

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Would 176 RA IgM factor be considered a low positive for rheumatoid factor. What would be considered a positive level. My ccp level is normal.

It is positive: The level is not as important as what is your clinical examination and other findings. The positive rheumatoid factor by itself does not mean you have arthritis. There are other things that you rheumatologist will look forward to help clarify whether the positive rheumatoid factor is due to rheumatoid arthritis or something else. ...Read more

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I had a positive ANA test and positive smith antibodies. Will they find ra?

I had a positive ANA test and positive smith antibodies. Will they find ra?

Lupus: A high-titer ANA and a positive anti-sm (smith) usually means systemic lupus rather than rheumatoid arthritis. This is much more manageable today than in the past. No lab means much in isolation, and your physician ordered these labs because he/she suspected lupus. If the diagnosis is established, you'll probably want to join a community group for people with sle. Good luck. ...Read more

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How quick can a blood work test for lupus or RA go from constantly being negative to finally showing up as a positive?

How quick can a blood work test for lupus or RA go from constantly being negative to finally showing up as a positive?

Check the Laboratory: Call the laboratory and make sure that their quality controls were within their established standard deviations on the batch of tests that your specimen was run and also find out any possibility of false positives for that particular method that they are using to do your test. ...Read more

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Does ANA 1:320 make diagnosis of RA more definitive? My RF was negative but I have multiple symptoms over 6 months. ANA positive 1:320

No: ANA actually isn't something we expect to be positive in rheumatoid arthritis. Your physician is thinking about lupus as a possible explanation, I'll bet. I'm sorry you're having this illness and difficulty in getting diagnosed, but this is common. Usually the nature of a systemic immune disease such as lupus or RA becomes clear over time unless it remits on its own. ...Read more

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Diagnosed with RA ten years ago RF negative , lupus malar and photosentive discoid rash over whole body, malar tested positive for Cutuneous lupus?

The question is?: So what is your question? There are only two possibilities. One is that you have 2 diseases, RA and lupus. The other is you never had RA, it was always just lupus. Ask your doctor or rheumatologist about it. ...Read more

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Intense joint pain in wrist, hands, shoulders. Blood tests, ESR at 28, CRP at 14 and rf factor at 44. Being referred to rheumy. Likely to have ra?

Intense joint pain in wrist, hands, shoulders. Blood tests, ESR at 28, CRP at 14 and rf factor at 44. Being referred to rheumy. Likely to have ra?

Yes.: You are the right age and have the right symptoms and lab work. Rheumatology evaluation is still imperative to delineate what type of inflammatory arthropathy you have and dictate/recommend treatment. ...Read more

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Dr thinks I have lupus & RA on 10mg methotrexate- I think its hypothyroidism.ANA positive Sed rate 42 RF 11 DNA AB 25.1 CCP anti 9 TSH 5 T4 .6 T3 (liothyronine) 3 ?

See a rheumatologist: RA and SLE are not diagnosed based on lab. These diseases are diagnosed based on a set of clinical and lab criteria. If there is a question about these diseases you should see a specialist in rheumatology ...Read more

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My ag ratio keeps testing at 2.9 high. I also have positive RA factor and fibromyalgia. Is this test connected in any way.

My ag ratio keeps testing at 2.9 high. I also have positive RA factor and fibromyalgia. Is this test connected in any way.

Often seen: ? Rheumatoid Arthritis (RA) fibromyalgia oft together. RA pain begets sedentariness, leading to soft tissue deconditioning & weakness. Gravity's impress on this dynamic co-generates chronic widespread soft tissue spasm & pain. Chronic muscle spasm generates a multitude of widespread painful ischemic/anoxic "micro-neuropathic" trigger points. Pain-interrupted sleep incites depression/sedentariness. ...Read more

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What medicine i could take for RA factor positive. .

What medicine i could take for RA factor positive. .

Need to know why +: Hey rheumatoid factor can be positive for many reasons. Everyone thinks of rheumatoid arthritis, a lot of other medical problems calling from his infectious problem lung problems to name a few. You need to discuss this with her physician, because what you need to look at it is to evaluate the cause of the cause of the rheumatoid factor and then decide what therapy is necessary should be instituted ...Read more

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I did an ra-factor test 2 and half year back and it was negative so if I do it now will it be positive(can it b positive after 2 n half year tym)?

I did an ra-factor test 2 and half year back and it was negative so if I do it now will it be positive(can it b positive after 2 n half year tym)?

Maybe: You do not mention anything about your symptoms. A positive rheumatoid factor is not necessary for a diagnosis of ra. The ccp antibody is a more specific diagnostic test. A rheumatoid factor can be negative early in the disease and become positive weeks or months later. ...Read more

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If I was diagnosed positive for ra, can I delay or prevent it ?

Possibly: You may want to get tested for gluten sensitivity and leaky gut. I know it sounds like an unlikely casue for ra, which is an autoimmune disease, but there is a growing body of evidence being published suggesting there is a correlation between sensitivity to a protein found in wheat, rye and barley (gluten), intestinal permeability (leaky gut) and autoimmune diseases like ra. ...Read more

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29 yo. Positive c reactive protein. They've diagnosis me with ra. Can this diagnosis be wrong? I've tried the medicine, but had no response.

Good question: Ra is diagnosed primarily by what your symptoms are. Typically RA patients have pain in small and large joints on both side of your body. Not all of the joints need to be symptomatic at once. 30 min to 1 hour of joint morning stiffness is typically present. The labssuch as crp, rf, ccp, ESR , may or may not help. If you have ra, it often takes a while to find the right medication or combo to work. ...Read more

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What does this mean doc- cra positive. Uric acid 5.7 RA negative?

Lab results: I don't know about a "cra" blood test. There's a standard CRP test, for c reactive protein. CRP is a marker for inflammation. An elevated CRP means that you have inflammation somewhere in your body from anything from a fall to a infection. Uric acid of 5.7 if you are not taking gout medicine you likely do not have gout. Ra neg - you do not have rheumatoid arthritis. :). ...Read more

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What is seronegative RA? Is that Positive Rheumatoid Factor and negative Anti CCP?

Seronegative RA: is when the rheumatoid factor is negative, one other common type of these are referred to as seronegative spondyloarthropathies or other seronegative disorders associted with inflammatory disease. there is a wide range ...Read more

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Aso titre positive 306 age 48 anticcp and RA factor negative.tell me the treatment?

What symptoms?: If you are trying to diagnose arthritis causes, all this tells you is that RA is not a likely diagnosis, but your doctor needs to continue with the evaluation. Good luck and hope this clears up quickly. ...Read more