Doctor insights on:
Why Do People With Cystic Fibrosis Have Unusually Salty Sweat
Extra loss: Cystic fibrosis is caused by a genetic mutation of cftr protein that moves chloride ions out of cells in respiratory tract, but into the cells in sweat gland ducts. Since cftr protein is not functional in CF pts, excess chloride gets secreted in their sweat, which causes the sweat to have higher salt concentration. That is why a sweat test measuring chloride is used as a diagnostic test for cf. ...Read more
No: Patients with CF don't sweat more, but their sweat is more concentrated and will taste saltier. ...Read more
Yes, Gold Standard: The gold standard for a diagnosis of CF is 2 back-to-back sweat chloride tests. However, the ability to run genetic tests and detect the disease in this fashion is becoming more common. In fact, it is now standard procedure in all 50 states for newborn babies to be screened, via blood from a heel prick, for cystic fibrosis. ...Read moreSee 2 more doctor answers
My son & wife tested neg for Cystic Fibrosis through screening test, not sweat test. However my son has hirschsprung disease. Should I test for CF - or it's high unlikely I have it? I'm 32. Feel fine
I wouldn't: There is no relationship between Hirschprung disease and CF. If you wand to know if you are an asymptomatic carrier of CF, the tests are available. However, you don't get to age 30 without symptoms when you have the disease and your fertility would also be diminished.If your wife is not a carrier, you can not produce babies with CF. ...Read moreSee 2 more doctor answers
My 3 1/2 yr. Old with cystic fibrosis has cold/ allergy symptoms...But unusually grumpy and purple color under eyes...Allergies or CF exacerbation?
Pls see answer: There is an overlap between the symptoms of allergy and cf. Allergic symptoms tend to be associated with a particular exposure that triggers an allergic response. The discoloration under the eyes may be caused by allergies, infection, lack of sleep, iron deficiency. If the area around the eye is red and swollen, it is best to check with your doctor. Fever > 101 is not usual for an allergic resp, . ...Read moreSee 1 more doctor answer
Cystic fibrosis: Patients with CF can suffer from sinus, respiratory, pancreatic, and biliary disease. They can also experience infertility, musculoskeletal disease, kidney stones, recurrent venous thrombosis, and small bowel obstruction. Obviously, some of these complications are associated with varying degrees of pain. It is probably more appropriate to ask about the overall morbidity of the disease. ...Read more
Treatment/infections: The life expectancy for cystic fibrosis has improved over the last decade. With close follow up, adherence to your medications, nutrition and exercise, you can improve your overall health. In addition, when there are flare ups called exacerbations, prompt treatment with antibiotics to treat the particular bacteria cultured is indicated. Prmgpedspulm can review records at fax 858 259 9689. ...Read more
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