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Doctor insights on: Why Do People With Cystic Fibrosis Have Unusually Salty Sweat

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Why do people with cystic fibrosis have unusually salty sweat?

Why do people with cystic fibrosis have unusually salty sweat?

CFTR: There is a defect in the sodium-chloride transporter encoded by the cftr gene results in an inability to appropriate consentrate saline in secretions (sweat, in the airway, in the pancrease) that are more viscous. ...Read more

Dr. William Walsh
980 doctors shared insights

Cystic Fibrosis (Definition)

Cystic fibrosis is a genetic disorder of the lungs and digestive tract. It causes recurrent lung infections and inhibits growth in patients. Average life expectancy of patients with cystic fibrosis ...Read more


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Cystic fibrosis sweat test -- who gives it?

Cystic fibrosis sweat test -- who gives it?

DNA vs. sweat tests: For sweat tests, do not trust a laboratory which is not accredited by the Cystic Fibrosis Foundation. "Sweat tests should be done at a Cystic Fibrosis Foundation-accredited care center". See http://www.cff.org/AboutCF/Testing/ ...Read more

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Why does cystic fibrosis cause a person's sweat to be abnormally salty?

Extra loss: Cystic fibrosis is caused by a genetic mutation of cftr protein that moves chloride ions out of cells in respiratory tract, but into the cells in sweat gland ducts. Since cftr protein is not functional in CF pts, excess chloride gets secreted in their sweat, which causes the sweat to have higher salt concentration. That is why a sweat test measuring chloride is used as a diagnostic test for cf. ...Read more

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Do people who suffer from cystic fibrosis sweat more than regular people do?

No: Patients with CF don't sweat more, but their sweat is more concentrated and will taste saltier. ...Read more

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Sweat chloride testing for cystic fibrosis=standard tests?

Yes, Gold Standard: The gold standard for a diagnosis of CF is 2 back-to-back sweat chloride tests. However, the ability to run genetic tests and detect the disease in this fashion is becoming more common. In fact, it is now standard procedure in all 50 states for newborn babies to be screened, via blood from a heel prick, for cystic fibrosis. ...Read more

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My son had a positive sweat test for cystic fibrosis. What next?

My son had a positive sweat test for cystic fibrosis. What next?

CFF.org: In addition to the answers provided, checking with your local children's hospital and the cff.Org for more information about your care is suggested. ...Read more

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My son & wife tested neg for Cystic Fibrosis through screening test, not sweat test. However my son has hirschsprung disease. Should I test for CF - or it's high unlikely I have it? I'm 32. Feel fine

My son & wife tested neg for Cystic Fibrosis through screening test, not sweat test. However my son has  hirschsprung disease. Should I test for CF - or it's high unlikely I have it? I'm 32. Feel fine

I wouldn't: There is no relationship between Hirschprung disease and CF. If you wand to know if you are an asymptomatic carrier of CF, the tests are available. However, you don't get to age 30 without symptoms when you have the disease and your fertility would also be diminished.If your wife is not a carrier, you can not produce babies with CF. ...Read more

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My 3 1/2 yr. Old with cystic fibrosis has cold/ allergy symptoms...But unusually grumpy and purple color under eyes...Allergies or CF exacerbation?

My 3 1/2 yr. Old with cystic fibrosis has cold/ allergy symptoms...But unusually grumpy and purple color under eyes...Allergies or CF exacerbation?

Pls see answer: There is an overlap between the symptoms of allergy and cf. Allergic symptoms tend to be associated with a particular exposure that triggers an allergic response. The discoloration under the eyes may be caused by allergies, infection, lack of sleep, iron deficiency. If the area around the eye is red and swollen, it is best to check with your doctor. Fever > 101 is not usual for an allergic resp, . ...Read more

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Do people with cystic fibrosis have a lot of pain?

Do people with cystic fibrosis have a lot of pain?

Cystic fibrosis: Patients with CF can suffer from sinus, respiratory, pancreatic, and biliary disease. They can also experience infertility, musculoskeletal disease, kidney stones, recurrent venous thrombosis, and small bowel obstruction. Obviously, some of these complications are associated with varying degrees of pain. It is probably more appropriate to ask about the overall morbidity of the disease. ...Read more

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Help please? How long do people with cystic fibrosis and diabetes live to be ?

Treatment/infections: The life expectancy for cystic fibrosis has improved over the last decade. With close follow up, adherence to your medications, nutrition and exercise, you can improve your overall health. In addition, when there are flare ups called exacerbations, prompt treatment with antibiotics to treat the particular bacteria cultured is indicated. Prmgpedspulm can review records at fax 858 259 9689. ...Read more