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Doctor insights on: Why Do Lupus Tests Sometimes Come Back Negative

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Why do lupus tests sometimes come back negative?

Why do lupus tests sometimes come back negative?

Not 100 %: There re several tests for lupus ana, double stranded dna and none of these tests is 100 per cent reliable for the diagnosis of lupus. A similar situation occurs in rheumatoid arthritis where there seedless negatives as well as false positives. If there is akin involvement a skin biopsy for direct exam as well as immunoflourescence can help with diagnosis. ...Read more

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Is it possible to have lupus but come back negative on the test or is the test the only way to tell?

Is it possible to have lupus but come back negative on the test or is the test the only way to tell?

Yes: the test may be negative in early LUPUS and may give false POSITIVES as well... No test is 100% "foolproof" ANTI-NUCLEAR antibodies and if positive a certain TYPE of anti-nuclear response may be helpful! Hope this info helps! Dr Z ...Read more

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I'm from the state of Wyoming & have Lupus. My tests while living there were very high. Now live in Michigan & all come back Negative is this normal?

Unusual: However it is theoretically possible if you had far more sun exposure in Wyoming than in Michigan given that sunlight can induce LE. On the other hand, your problem may be from another autoimmune disease . If you are feeling well otherwise, no test is needed. But if you do have symptoms then I would suggest repeating the test in case there was a blood sample mix-up. ...Read more

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Can you have lupus if your ANA come back negative?

Can you have lupus if your ANA come back negative?

Unlikely, but...: The ANA is a very sensitive test, so it tends to have too many false positives, rather than false negatives. Textbooks talk about lupus with negative ANA results, but i suspect this is only a tiny percentage of lupus patients. Sometimes other labs or procedures can be helpful. Speak to your doctor. ...Read more

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Have lupus and now tests come back normal why are dr's looking at me crazy and telling me nothing's wrong? Just cause nothing is going crazy?

Lupus: Lupus is a condition that has very specific criteria for diagnosis, based on symptoms, findings on examination, and blood testing. Ultimately, if you have it , it may go in remission with treatment but it never goes away. ...Read more

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In 11/2014 I was hospitalized with bilateral PE. 3 lupus anticoagulant tests have come back positive, and he said it's primary. Does that mean APS?

In 11/2014 I was hospitalized with bilateral PE.  3 lupus anticoagulant tests have come back positive, and he said it's primary.  Does that mean APS?

Almost...: In my experience it can be primary, but other autoimmune disease must be excluded. IgM, followed by IgG anti -cardiolipin antibodies are the most problematic! This is important, since apart from anticoagulants, other drugs may be needed. ...Read more

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All tests for lupus and arthritis come back normal each time. However, I have a lot of fluid retention everyday as well as joint pain. Other causes?

All tests for lupus and arthritis come back normal each time. However, I have a lot of fluid retention everyday as well as joint pain. Other causes?

Fluid retention?: Fluid retention is not associated with autoimmune disease unless the kidneys have been damaged (Lupus). Perhaps your salt intake is too high. As for your joint pain, you need to consult an orthopedist to find out the cause. ...Read more

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My cardiolipin IgM has come back high 3 times, neutrophils slightly raised & ANA negative. symptoms indicative of Lupus, MCTD?? Gp not worried.

My cardiolipin IgM has come back high 3 times, neutrophils slightly raised & ANA negative. symptoms indicative of Lupus, MCTD?? Gp not worried.

See a rheumatologist: The lab tests may be unreliable especially at hospital labs. Even if negative the anticardiolipin ab may be a concern depending on your symptoms. IgM anticardiolipin Anyibody us also for many not a problem. It us best if you are having symptoms to see a specialist and get their opinion. ...Read more

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Would coming off prednisone cause my lupus to come back?

Would coming off prednisone cause my lupus to come back?

Indirectly: You stop the prednisone, it's not going to cause the inflammation that comes from lupus. But if the lupus activates, then you would see it because there is nothing stopping the inflammation. If the lupus is in remission, it will not come back. ...Read more