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Doctor insights on: Why Do I Have A Headache From Effexor

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I've had a headache since taking Effexor (venlafaxine) last night. (1st dose.) Should I just ignore, continue taking? Slight jitters, too.

I've had a headache since taking Effexor (venlafaxine) last night. (1st dose.) Should I just ignore, continue taking? Slight jitters, too.

Normal: This is a normal response to antidepressant medications. The side effects usually go away in 7-10 days. I would recommend to continue taking it and speak to your doctor if you can not tolerate the side effects. ...Read more

Dr. Bennett Machanic
4,162 doctors shared insights

Headache (Definition)

The medical term is cephalalgia. It is a feeling of pain that can occur on either both sides or just one side of the head or neck. Headaches can be sharp, dull, or throbbing, and can radiate to different areas of the head. They typically last less than an hour but can ...Read more


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After a year of taking Effexor (venlafaxine) daily I'm going off of it per my doctors instructions. I am having relentless painful dizzying headaches. Please help. ?

After a year of taking Effexor (venlafaxine) daily I'm going off of it per my doctors instructions. I am having relentless painful dizzying headaches. Please help. ?

Going off Effexor (venlafaxine): Let's assume your doctors have good reasons. But it could entail a discontinuation syndrome, if your doctor doesn't do it right. Make sure you have the correct tapering instructions. It could also result in your re-experiencing symptoms that Effexor (venlafaxine) was treating. Your doctor should be ready with an alternative medicine. ...Read more

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Going off of 37.5 mg Effexor (venlafaxine) per my MD's instructions and I am having horrible headaches that won't go away. I've tried all medications. Please help. ?

Going off of 37.5 mg Effexor (venlafaxine) per my MD's instructions and I am having horrible headaches that won't go away. I've tried all medications. Please help. ?

See doctor: I answered your question yesterday. Did you contact your doctor? If you can't reach doc and are having "horrible headaches," you should go to urgent care to be evaluated for a proper diagnosis and guidance. Perhaps something else is going on besides Effexor (venlafaxine) withdrawal. You need to be seen by doctor. I hope you follow up without delay. Take care. ...Read more

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Is it safe to be taking 200mg of Zoloft and 187.5mg of effexor (venlafaxine)? The dose for Effexor (venlafaxine) was increased recently and i've noticed rapid hr/nausea/headache.

Talk to your MD now: Effexor (venlafaxine) metabolism is reduced by zoloft (200mg) via zoloft inhibition of the enzyme (p450 2d6) that helps to break Effexor (venlafaxine) down. Depending on your genetic variant of 2d6, you could have an elevated blood level with this combination thus leading to excessive sympathetic activation; elevated risk for 5ht syndrome, extra GI upset; and no libido. Please see the prescribing md asap or get 2nd opinion. ...Read more

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Sexual side effects from Effexor (venlafaxine) I'm taking Effexor (venlafaxine) for headaches and i can no longer ejaculate unless i try really hard for a long time and it's exhausting. Normally i can ejaculate within a minute now it's taking 10 or more.

Do : Do you have a specific question? I'd probably be bothered by the symptoms you are describing, which are definitely possible from taking effexor (venlafaxine). I'd recommend going back to the physician prescribing this medication and discuss alternatives. ...Read more

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Having terrible headaches that won't go away after going off of Effexor (venlafaxine) per my MD's instruction. Dizzy and nauseous as well. OTC meds not helping. ?

Having terrible headaches that won't go away after going off of Effexor (venlafaxine) per my MD's instruction. Dizzy and nauseous as well. OTC meds not helping. ?

Effexor (venlafaxine) withdrawal: See your doctor without delay for best guidance. I don't know your Effexor (venlafaxine) dose, how/if you tapered, when you took your last pill, etc. If restarting Effexor (venlafaxine) at a low dose relieves headaches, dizziness and nausea, you may need to taper more slowly. Stopping an antidepressant requires careful medical supervision and knowing the details of your situation. I hope this helps. ...Read more

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Friend taking Effexor (venlafaxine) for 3 days. Has had mild side effects such as dry mouth, no appetite, headache and insomnia. Now has kyphosis. PERRLA absent. ?

Friend taking Effexor (venlafaxine) for 3 days. Has had mild side effects such as dry mouth, no appetite, headache and insomnia. Now has kyphosis. PERRLA absent. ?

Kyphosis?: Kyphosis cannot come on quickly - it is an abnormal curvature of the upper spine. Are both of his pupils unequal, abnormally shaped and unreactive to light and accomodation? If so, then there is a serious problem and he should be evaluated. The other side effects described are common for effexor (venlafaxine) and will usually subside after 4-6 weeks. ...Read more

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Started Effexor (venlafaxine) 75mg have nausea headaches jaw tremors anxiety worse insomnia didn't have these sideeffects when I took 6 yrs ago how long will itlast?

Started Effexor (venlafaxine) 75mg have nausea headaches jaw tremors anxiety worse insomnia didn't have these sideeffects when I took 6 yrs ago how long will itlast?

Need more info.: These side effects more than likely will not abate until you either stop the Effexor (venlafaxine) or reduce the dose.. DO NOT do this until advised so by your physician. Rapid and unsupervised changes in medications like Effexor (venlafaxine) also have certain side effects. ...Read more

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I took Effexor (venlafaxine) XR for the first time today. It made me throw up and have a terrible headache. My muscles ache and i feel so tired. Is this normal?

It can happen: It's not "normal" [because this is an uncomfortable symptom], but it's common for Effexor (venlafaxine) to cause some nausea at first. If it made you throw up, that's pretty intense. I suggest calling your doctor about this -- and see if you can't start at a lower dose. Perhaps that will help, with a more gradual titration to therapeutic level. If not, your doctor can change to a different medicine. ...Read more

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I have osteoporosis. My dr. Prescribed Nortrptaline and Tramadol as I did not want narcotic pain meds. I've been experiencing rigidity, terrible headache and severe pain. I had already been on Effexor and another antidepressant. She told me these sympt

I have osteoporosis.  My dr. Prescribed Nortrptaline and Tramadol as I did not want narcotic pain meds. I've been experiencing rigidity, terrible headache and severe pain.  I had already been on Effexor and another antidepressant.  She told me these sympt

Concerned: mixing several types of antidepressants with TCA ( nortriptalime) has potential for some serous side effects. If pain and headache started soon after you took new medicine I would stop it and see a doctor or ER. Make sure to bring all of your meds so they can check for interactions. ...Read more

Dr. Krishna Kumar
518 doctors shared insights

Venlafaxine (Definition)

It belong to classification of snri antidepressant also help anxiety start slow go slow its approved for depression and anxiety disorder there are some common side effects important never stop suddenly always taper slowly if you ever ...Read more


Effexor (Definition)

Venlafaxine is a non-tricyclic which is a kind of serotonin-norepinephrine reuptake inhibiting drug (atypical anti-psychotic ...Read more