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Why Can It Be Dangerous To Administer Drugs To Patients In Renal Failure
Medications in RF: Many medications and/or the byproducts that come from taking a medication have to get out of your body by way of your kidneys. Also, some medications can, at high levels in your blood, damage your kidneys. Virtually every drug given to a renal failure patient needs to first be looked at from the standpoint of the need to alter dosing before being given. This is really important. ...Read moreSee 1 more doctor answer
A condition in which your kidneys suddenly stop working normally. Since your kidneys remove waste products and help balance water and salt and other minerals (electrolytes) in your blood, when your kidneys stop working, waste products, fluids, and electrolytes build up in your body. This can cause problems ...Read more
How do I find out why can it sometimes be dangerous to administer drugs to patients in renal failure?
Many: These patients can still eat any foods, but they just need to decrease the amount of potassium and phosphorous containing foods. Just as a diabetic can eat any sweets, they need to limit it. Renal failure patients need to limit total fluids, potassium and phosphorous. If on dialysis, protein is usually encouraged, but if pre-dialysis, high protein intake may not be a good idea. ...Read more
The kidneys are sick: When you are young and healthy and the kidneys function normally, they can eliminate salt you take in more efficiently. When the kidneys are sick, they lose the ability to get rid of the extra salt, thus body will accumulate excess salt = bad--cause fluid retention, hypertension, heart failure etc..As a result, many things should be restricted in renal failure patient. Consult doc. Good luck. ...Read moreSee 1 more doctor answer
Clofibrate: Clofibrate is a lipd lowering drug that is metabollized in the liver. Those metabolites are excreted in the kidney. When renal failure/insufficiency happens, the drug itself as well as its metabolites build up in the blood. High concentrations of these metabolites can lead to serious side effects including death. So, don't take Clofibrate if you have renal disease. ...Read more
Atracurium use: The reason atracurium can be used in hepatic and renal failure patients is because the breakdown process is not dependent on kidney are liver function. The drug is broken down through a process called the hoffman eleimination that is independent of organ activity. However, the main metabolite is laudanosine and it can acumulate in elderly renal and liver failure patients. ...Read more
Metabolism: Atracurium is a non-depolarizing neuromuscular blocker. It is metabolized via a process called Hoffmann elimination (ester hydrolysis which is independent of renal, hepatic or enzymatic function). Since you don't need the liver or kidney to metabolize the drug, it is a paralytic often used for patients with renal and/or hepatic failure. ...Read more
?: Indicate for what? You need to clarify this question. ...Read more
Stage 4 RF: Stage 4 patients have GFR between 15 & 30. I approach this from the standpoint of preserving what kidney function you have, not life expectancy. Ways to do that - watch your diet and avoid foods that have lots of potassium and salt; limit protein intake; watch your weight; take all medicines prescribed; see your doctor regularly. Look here : http://www.Kidneyfailureweb.Com/prognosis/221.Html. ...Read more
Elimination mechani: Atracurium is not dependent on liver or kidneys for elimination, so it wears off normally in these patients. ...Read more
Reducerythropoietin : In significant chronic renal failure the hormone erythropoietin is produced in lower amounts. If the anemia is severe and there is no other type of anemia (usually less that 11) and if pt is symptomatic this substance can be given in form of injection (procrit (epoetin alfa) and others). ...Read moreSee 1 more doctor answer
Risk of bleed: Ffp has coagulation factors and is usually given to decrease the risk of bleeding. Some kidney diseases are also associated with abnrmalities in coagulation, therefore may need ffp. Kidney disease per se can increase the bleeding risk as some cells do not work well in kidney failure. Usually FFP are given when there is ongoing bleed, or there is high risk of bleed, or when procedure is planned. ...Read more
Need a lot more info: You've given too little detail, so you'll need to provide us with more. When you say renal failure, do you mean end-stage renal disease, acute renal failure, chronic renal failure, or something else? What other things are happening with the patient besides the occasional fever? What region of the world is the patient in? Any other concomitant illnesses? How high is the fever? ...Read more
Anemia and ESRD: This patient must be on dialysis. At his dialysis center, he should be receiving Epogen (epoetin alfa) to increase the hb level. There are some people that have a problem with EPO and do not raise their hb level, due to anti-epo antibodies and is rare. Other causes of no increase of hb levels are blood loss from the GI tract, hemolysis and high parathyroid hormone levels. Ask the patient's nephrologist about it. ...Read more
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