Top
10
Doctor insights on: Why Are Sclera Blue In Osteogenesis Imperfecta

Share
Dr. Heidi Fowler
95 doctors shared insights

Osteogenesis Imperfecta (Definition)

Osteogenesis imperfecta is a condition causing extremely fragile bones. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene. The severity of OI depends on ...Read more


2

2
What causes the blue sclera in osteogenesis imperfecta oi?

Thin sclera: Osteogenesis imperfecta amongst its other problems, produces a thinning of the white outer coat of the eyeball, the sclera. Because of this the dark inner lining, the uvea, adds its coloration to light striking the thinned sclera and the result is a blue color. The condition does not actually infuse the sclera with blue - it is an optical effect. ...Read more

See 2 more doctor answers
3

3
What can lead to the blue sclera in osteogenesis imperfecta?

What can lead to the blue sclera in osteogenesis imperfecta?

It doesn't: Where the sclera is thin, it appears blue from the deoxygenated blood the choroidal blood vessel layter next tot he sclera. This is normal in patients who are nearsighted. Rarely, this is a sign associated with osteogenesis imperfecta. Not a cause. Not diagnostic. ...Read more

5

5
I am 28 & when move my eyes right and left i see ting of blue sclera is it normal or any kind of problem and there is no genetic osteogenesis problm?

I am 28 & when move my eyes right and left i see ting of blue sclera is it normal or any kind of problem and there is no genetic osteogenesis problm?

Blue Sclera: There are other causes of blue sclera besides osteogenesis imperfecta. Other causes can include: medication effects, topical eye drops, exposure to silver compounds, collagen synthesis disease, and alkaptopuria. It would be best to have this evaluated by an opthomologist. ...Read more

See 1 more doctor answer
6

6
Can you tell me about osteogenesis imperfecta?

Can you tell me about osteogenesis imperfecta?

Genetic disease: For excellent general info go the NIH website here: http://ghr.Nlm.Nih.Gov/condition/osteogenesis-imperfecta. ...Read more

See 1 more doctor answer
7

7
What organ systems can be affected by osteogenesis imperfecta?

What organ systems can be affected by osteogenesis imperfecta?

Bones teeth eyes: Brittle bones poor dentition and blue sclerae (whites of the eyes) are common features of oi. ...Read more

See 1 more doctor answer
8

8
What to do if I have type 1 osteogenesis imperfecta? What is this?

What to do if I have type 1 osteogenesis imperfecta? What is this?

Sounds like you may: not have it. It is a collagen disorder which causes "brittle bones". The diagnosis is made by a very difficult collagen analysis which takes about 2 months, usually at Dr. Peter Buyer's lab at the U.of Washington. It may be passed from generation to generation. Characterized by multiple fractures from trivial forces. Very variable--one sib may have 20 fractures, and another may have none. ...Read more

9

9
Please help! what is the mode of inheritance for osteogenesis imperfecta?

OI mostly dominant: There are many types of osteogenesis imperfecta. Most are inherited in an autosomal dominant pattern (=one copy of the altered gene sufficient to cause condition). Some inherit it from a parent, others arise spontaneously (sporadic, de novo) in a child. Some types of oi are inherited in autosomal recessive manner which means that each parent is a carrier but does not have symptoms. ...Read more

Dr. Linda DiMeglio
70 doctors shared insights

Brittle Bone Disease (Definition)

Osteogenesis imperfecta is a condition causing extremely fragile bones. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene. The severity of OI depends on ...Read more


Sclera (Definition)

The sclera is the white hard covering of the eye. It creates the actual "eye ball" and is made out of dense connective tissue. The conjunctiva is a thin, clear ...Read more