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Doctor insights on: Why Are Sclera Blue In Osteogenesis Imperfecta

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Dr. Linda DiMeglio
70 doctors shared insights

Brittle Bone Disease (Definition)

Osteogenesis imperfecta is a condition causing extremely fragile bones. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene. The severity of OI depends on ...Read more


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What causes the blue sclera in osteogenesis imperfecta oi?

Thin sclera: Osteogenesis imperfecta amongst its other problems, produces a thinning of the white outer coat of the eyeball, the sclera. Because of this the dark inner lining, the uvea, adds its coloration to light striking the thinned sclera and the result is a blue color. The condition does not actually infuse the sclera with blue - it is an optical effect. ...Read more

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What can lead to the blue sclera in osteogenesis imperfecta?

What can lead to the blue sclera in osteogenesis imperfecta?

It doesn't: Where the sclera is thin, it appears blue from the deoxygenated blood the choroidal blood vessel layter next tot he sclera. This is normal in patients who are nearsighted. Rarely, this is a sign associated with osteogenesis imperfecta. Not a cause. Not diagnostic. ...Read more

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I am 28 & when move my eyes right and left i see ting of blue sclera is it normal or any kind of problem and there is no genetic osteogenesis problm?

I am 28 & when move my eyes right and left i see ting of blue sclera is it normal or any kind of problem and there is no genetic osteogenesis problm?

Blue Sclera: There are other causes of blue sclera besides osteogenesis imperfecta. Other causes can include: medication effects, topical eye drops, exposure to silver compounds, collagen synthesis disease, and alkaptopuria. It would be best to have this evaluated by an opthomologist. ...Read more

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What does a light blue sclera mean?

What does a light blue sclera mean?

This depends: This usually refers to thin sclera, thin enough so that the blueish hues of the darker inner eye can be seen. Blue sclera can be seen with simple aging, ocular abnormalities like scleritis or more systemic conditions like osteogenesis imperfecta. ...Read more

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Can you tell me what it mean when a person has light blue sclera?

Underlying pigment: Normal sclera is opaque and quite white. If it thins out for some reason, the underlying pigmented uvea adds a bluish hue to the sclera at that point. Things that thin the sclera are certain inherited conditions like ehlers-danlos or trauma, elevation of the eye pressure in the young and some chronic inflammatory eye diseases. ...Read more

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What does it mean when a person has blue sclera?

Osteogenesis imperfe: This classic finding in osteogenesis imperfecta is due to thin connective tissue in the sclera. However, children may have slightly blue tinted sclera without having oi. ...Read more

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I have blue sclera but mine is different since I had tatooing. Whats the big deal?

I have blue sclera but mine is different since I had tatooing. Whats the big deal?

OI: In medicine, blue sclera can be the sign of a serious medical condition. The most well-known is osteogenesis imperfecta - a genetic disease in which the bones are brittle and break very easily. Kids have a horrible life because of this. A very superficial example is in m night shyamalan's unbreakable. ...Read more

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Causes of blue sclera in infants include what?

See below:: Blue sclerae are most importantly associated with types i and ii osteogenesis imperfecta, the latter of which is fatal and thus not seen in adult practice. Other associations include: ehler's danlos syndrome pseudoxanthoma elasticum marfan's syndrome a blue sclera may also be acquired through long-term use of corticosteroids. ...Read more

Sclera (Definition)

The sclera is the white hard covering of the eye. It creates the actual "eye ball" and is made out of dense connective tissue. The conjunctiva is a thin, clear ...Read more


Blue Sclera (Definition)

Blue sclera refers to a bluish color of the whites of the eyes. It can be seen in certain medical conditions, such as the ...Read more