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Doctor insights on: Who Should Avoid Taking Tamoxifen

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Who should avoid taking tamoxifen?

Who should avoid taking tamoxifen?

Blood clots: Pts with a history of blood clots and/or a history of abnormal pap smears should not take tamoxifen. If there is a family history of clotting disorders or uterine cancer, tamoxifen should not be used. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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Why would my doctor tell me to avoid tamoxifen?

Why would my doctor tell me to avoid tamoxifen?

Risks vs. benefits: Tamoxifen is a very effective drug for the prevention and treatment of hormone-sensitive breast cancer. However, like all medications, there are small risks associated with tamoxifen, including a risk of blood clots, stroke, uterine cancer, and cataracts. I would suspect that your dr. Felt that the risks outweighed the benefits in your case or that your cancer was not sensitive to tamoxifen. ...Read more

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Is there anyway to avoid weight gain and hair loss while on tamoxifen ?

Is there anyway to avoid weight gain and hair loss while on tamoxifen ?

Hair loss tamoxifen: Tamoxifen related hair loss is androgenetic due to blockade of the female hormones. One of the first steps we have to treat female (or male) pattern hair loss is topical minoxidil. It does not involve any hormones and therefore should not interfere with your treatment of breast cancer. Also, thyroid problems can contribute to hair loss, as can iron deficiency. I suggest having both checked. ...Read more

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Does taking tamoxifen benefit women with cdis?

Does taking tamoxifen benefit women with cdis?

Yes.: Women with a history of ductal-carcinoma-in-situ (dcis) may have a 50% reduction in developing a second breast cancer when taking tamoxifen for 5 years ("chemoprevention"). Furthermore, following a lumpectomy, the combination of tamoxifen and radiation therapy may have a decreased risk of cancer recurrence in the affected breast greater than either therapy alone. ...Read more

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Is it possible for me to just stop taking tamoxifen?

Of course: But is it advised by yoiur doctor or not? Please check if it is time to stop or not. If you have received the maximum possible benefit, then you can stop it and you will not have ill effects due to tamoxifen. ...Read more

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What are the common risk factors for taking tamoxifen?

What are the common risk factors for taking tamoxifen?

Side effects?: The most experienced side effects of all hormonal therapy are menopausal symptoms (ie.Hot flashes, etc). There is a small increased risk of blood clots similar to hormone replacement therapy, in women with an intact uterus, there can be irreg bleeding and thickening of the uterine wall. If ignored this can rarely progress to uterine cancer that can be cured with a hysterectomy. ...Read more

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I'm having hot flashes when taking tamoxifen. Is there anything I can do?

I'm having hot flashes when taking tamoxifen. Is there anything I can do?

Yes: Tamoxifen interferes with estrogen action causing hot flashes. Taking estrogen to control hot flashes would defeat the primary reason to take tamoxifen so that is not an option. Some women with hot flashes are helped by taking some antidepressants (ssri). Another option is to try clonidine, a blood pressure medication. Non of these are 100% effective, but some women definitely benefit from them. ...Read more

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How does tamoxifen actually work?

How does tamoxifen actually work?

Blocks estrogen: Some breast cancer cells have receptors on them that bind to estrogen in order to grow. Tamoxifen acts as an "antagonist" and blocks estrogen from binding to these receptors on the cancer cells by binding to them first. With tamoxifen sitting in estrogen's place, the cancer cell can no longer grow. ...Read more

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How much tamoxifen is recommended?

How much tamoxifen is recommended?

Once per day: Tamoxifen is most commonly used to treat breast cancer. The dose is (usually) 20mg per day and taken for 5 years. This medication is also used for people considered "high risk" for breast cancer to help decrease their risk of developing it in the future. I recommend you speak with your oncologist about specific recommendations for your case. ...Read more

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What are the effects of tamoxifen ?

Blocks ER: Tam binds and blocks signals to the estrogen receptor present in er+ breast cancer. While this has benefits in cancer treatment it produces side effects - menopausal symptoms, possible uterine wall thickening & even malignancy if ignored, & increased risk of blood clots (similar to hormone replacement). In most cases of ca the benefits far outway the risks but must be weighed in risk reduction. ...Read more

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Is there an alernative to tamoxifen?

Yes: For breast cancer treatment, aroma taste inhibitors are often used in place of tamoxifen , only in post menopausal women. ...Read more

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