Doctor insights on:
Who Can Use Methotrexate Psoriatic
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
Indometh for gout: While the combination of nsaids with Misoprostol can help relieve the inflammation caused by arthritis one should consult with their doctor about the best nsaid. This is because long term use of nsaid's also carry potential risks for renal, cardiac and GI issues. Cox 2 inhibitors have also been found effective for arthritis and now diclofenac which is an NSAID is available as a gel and a patc. ...Read moreSee 1 more doctor answer
See details: The two major DMARDs for treating psoriatic arthritis are Methotrexate and the biologics such as Remicade, (infliximab) Enbrel and Humira among others. All are extremely effective, especially the biologics. All have potential side effects such as infection risk, reduced blood counts and liver disease. ...Read more
Recently diagnosed with psoriatic arthritis & prescribed enbrel (etanercept). How effective, in the long term, are these injections? Any downsides? Thank you!
Extremely effective: Tnf agents are extremely effective in the treatment of psoriatic arthritis. It is surprising that the side effects were not reviewed with you prior to starting the med. The major risk is infection with other possible side effects being reduced blood counts, liver inflammation, neurologic disorders and a possible increased risk of lymphoma. ...Read moreSee 1 more doctor answer
Would any rheumatologist ever suggest enbrel (etanercept) to a patient who doesn't have rheumatoid arthritis, anspon, juvenile or psoriatic arthritis? Serious drug
If someone is misdiagnosed with sle & start using sle med (plaquenil, prednisone, imuran) will he get sle or any other disease?
Infliximab: "Remicade (infliximab) at doses >5 mg/kg should not be administered to patients with moderate to severe heart failure. " "Remicade (infliximab) should not be re-administered to patients who have experienced a severe hypersensitivity reaction to Remicade (infliximab). Additionally, Remicade (infliximab) should not be administered to patients with known hypersensitivity to inactive components of the product or to any murine proteins.: See: ...Read more
RA + psoriasis. MTX allergy. Enbrel (etanercept) non effective. Humira semi-effective but Vectra score 30 with extreme fatigue. MD wants to try Xeljanz?
RA + psoriasis: There are a number of newer medications that could help you. Xeljanz works by disrupting cytokine and growth factor signaling pathways. A trial of the medication is useful to see whether it helps you. Other medications that might help include Remicade (infliximab) and Apremilast ...Read more
With close monitorin: With close monitoring.Get a more detailed answer ›
Dx:ra. Enbrel (etanercept) not effective after 6 mo. Humira 2x mo prescribed. Liver can not tolerate mtx. What medication can replace mtx to make humira work best?
Humira losing its effectiveness with RA. Unable to tolerate MTX or Plaquenil. Any Rheumotologists think Remicade (infliximab) would be a good option?
Can't hurt to try: I'm a family doctor, not a rheumatologist, but I do have RA patients who are on Remicaid who are responding very well with it. I don't know what that's worth to you, but I thought I would share. I think it's being used a lot more and does have FDA indication for RA. ...Read moreSee 1 more doctor answer
Imuran (azathioprine): "IMURAN (azathioprine) should not be given to patients who have shown hypersensitivity to the drug. IMURAN (azathioprine) should not be used for treating rheumatoid arthritis in pregnant women. Patients with rheumatoid arthritis previously treated with alkylating agents (cyclophosphamide, chlorambucil, melphalan, or others) may have a prohibitive risk of malignancy if treated with IMURAN (azathioprine)." See: ...Read more
Better to be on methotrexate and hydroxychloroquine or methotrexate and a biologic when treating jra? Methotrexate only doesn't help
Depends on severity: Since you have already been on Methotrexate and its not helping you get complete relief from symptoms, further addition of therapies will depend on severity of your current symptoms. Hydroxychloroquine is milder in efficacy as compared to biologics & both have different side effect profiles. Talk to a rheumatologist who can assess your clinical course & treatment needs & then advise accordingly. ...Read moreSee 1 more doctor answer
Saw rheumy. Today.Gave me arava (leflunomide) 20mg+methotrexate 25mg+enbrel for psoriasis/psor.Arthritis.Is it safe, r all 3 used frequently/sometimes, opinion please ?
Psoriatic Arthritis: Methotrexate (trexall) is the most common dmard used to treat psoriatic arthritis. However, it has potentially serious side effects, including lung, kidney and liver problems. Using Arava and Methotrexate together my increase the risk of hepatotoxicity & leukopenia.I would just use a biologic like Remicade or Humira or Enbrel or stelara (ustekinumab) which should control your disease but this is my opinion. ...Read moreSee 1 more doctor answer
How effective is imuran (azathioprine) for lupus or sjogrens? Methotrexate worked great for me but can't tolerate GI side effects even with injection.
Yes. Agree, but....: Methotrexate can be very effective. However, the first studies raising the specter of liver disease came from psoriasis patients on daily low dose oral mtx!. The first pass effect is dangerous for the liver. Mtx cannot be adjudicated aqs an oral drug. Absorption is variable (40-90%), causes GI upset, and hits the liver first. I only use subcutaneous mtx once weekly. This is the safest! ...Read moreSee 1 more doctor answer
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