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Doctor insights on: White Matter Disease Causes

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Dr. Walter Husar
Board Certified, Neurology
27 years in practice
3M people helped
1

1
I have white matter disease and the neurologist didn't really tell me that it would cause cognitive issues. Will these issues get better?

I have white matter disease and the neurologist didn't really tell me that it would cause cognitive issues. Will these issues get better?

Maybe...: Really depends on the location and the number of white matter lesions. In demyelinating disorders such as multiple sclerosis if having a increase lesion burden, cognitive dysfunction will occur. Otherwise, the number and location is important to determine whether there'll be any memory or cognitive issues. ...Read more

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Dr. Keegan Duchicela
Board Certified
8 years in practice
15M people helped
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White Matter (Definition)

White matter is one of the two components of the central nervous system and consists of glial cells and myelinated axons that transmit signals from one region of the cerebrum to another and between the cerebrum and lower brain centers. White matter tissue of the freshly cut brain appears pinkish white to the naked eye because myelin is composed largely of lipid ...Read more


Dr. Douglas Bourgon
Board Certified, Radiology
16 years in practice
9K people helped
2

2
Can ischemic small vessel disease cause gliosis? How would ischemic small vessel disease be treated in a minimal area of white matter in the brain?

Can ischemic small vessel disease cause gliosis?  How would ischemic small vessel disease be treated in a minimal area of white matter in the brain?

Yes.: White matter changes frequently seen on brain MRI are the result of chronic small vessel ischemic disaease and it is the resulting small focus of gliosis that shows on the MRI imaging. Treating your underlying cardiovascular heath is key, not the MRI finding. ...Read more

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Dr. Keegan Duchicela
Board Certified
8 years in practice
15M people helped
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Dr. Donald McCarren
Board Certified, Neurology
30 years in practice
812K people helped
3

3
What is chronic white matter ischemic disease?

What is chronic white matter ischemic disease?

Lack of blood deep : In the brain. This condition is most commonly seen in individuals with one or all of the following: 1. Hypertension 2. Diabetes 3. Hyperlipidemia (high cholesterol) 4. Cigarette smoking 5. Family history of stroke of course there are others but these are most important. Please meet with your neurologist to discuss why and what you can do to help your situation. Good luck and well wishes. ...Read more

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Dr. Bennett Machanic
Board Certified, Neurology
46 years in practice
47M people helped
4

4
Mild supratentorial white matter disease--what is this?

Mild supratentorial white matter disease--what is this?

Maybe of no signif.: White matter lesions may be caused from a host of circumstances, such as migraine, prior head or neck trauma, hardening of the arteries, inflammation like multiple sclerosis, prior small strokes, effect of some medications such as methotrexate, and is not specific. The location of your concern maybe actually a chronic, lifelong issue. Consult your doctor. ...Read more

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Dr. Keegan Duchicela
Board Certified
8 years in practice
15M people helped
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Dr. Bennett Machanic
Board Certified, Neurology
46 years in practice
47M people helped
6

6
I had a MRI that showed minimal white matter disease that was not addressed. Now im having signs of MS. ?

I had a MRI that showed minimal white matter disease that was not addressed. Now im having signs of MS. ?

Get re-evaluated: The MRI may well be nonspecific, and the result of migraine, old head trauma, smoking, etc. But if you now have neurological symptoms, and "signs", this needs to be evaluated fully and diagnosed, so that the appropriate cause can be treated. This may not necessarily be MS, and certainly best to find out. ...Read more

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Dr. Kenneth Liu
Board Certified, Neurosurgery
14 years in practice
198K people helped
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Dr. Bennett Machanic
Board Certified, Neurology
46 years in practice
47M people helped
8

8
I asked earlier about MS and white matter disease. I have had an MRI (2) actually. Shows lesions. "stroke" in october. But wad told not a stroke?

I asked earlier about MS and white matter disease. I have had an MRI  (2) actually. Shows lesions. "stroke" in october. But wad told not a stroke?

Need to sort out: Regarding your specifics, would check images of both neck and head, and even consider lumbar puncture. MS patients can certainly have strokes, and my concern with you involves possibility of a very different disease than MS, such as anti-phospholipid antibody syndrome, arteritis, lupus, even sarcoidosis. Highly recommend opinion from university hospital neurology service. ...Read more

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Dr. Mijail Serruya
Board Certified, Neurology
10 years in practice
40K people helped
9

9
What is chronic periventricular white matter microvascular ischemic disease?

What is chronic periventricular white matter microvascular ischemic disease?

Patchy insulation: Chronic means this process has been going on for years in the brain. White matter is the part of the brain where the "communication cables" are, and they are "white" because of myelin insulation. The ventricles are fluid-filled "shock absorber" spaces inside the brain. Ischemic means they have been deprived oxygen, microvascular means in tiny blood vessels. Mini-stroke strips off some insulation. ...Read more

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Dr. Tonda Anderson
Board Certified, Family Medicine
14 years in practice
75K people helped
10

10
I had an MRI done an it says mild patchy white matter hyperintensity of the pons is stable likely representing microangiopathic disease mean what doe?

I had an MRI done an it says mild patchy white matter hyperintensity of the pons is stable likely representing microangiopathic disease mean what doe?

Small vessel disease: "microangiopathic" means "small vessel disease, " implying that you have some small blood vessel damage due to high blood pressure, diabetes, or high cholesterol ("hardening of the arteries"). This is your warning that chronic problems such as those (if you have any of them that you know of) need to be addressed. ...Read more

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Dr. Keegan Duchicela
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