Doctor insights on:
Which Is The Most Dangerous Type Of Leukemia In Adults
A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
Four categories...: They are acute myeloid or acute lymphoid leukemia (aml and all), and chronic myeloid or chronic lymphoid leukemia (cml and cll). However, there are variants within each of these categories that reflect their unique molecular natures. The categories simply reflect the expression of markers of differentiation along each of these lineages and the ability to mature. More specific info if you wish.See 1 more doctor answer
Rarely causes pain: It is uncommon to have pain as a symptom of leukemia. But if you have it then it is likely to be from the bones, most often from the pelvic/low back area. But you should know what type of leukemia you are dealing with (?) as there are 4 different types which can be either acute or chronic leukemia, with entirely different symptoms from one to the other (s).
Several...: It's difficult to say in just a few words but, generally speaking, at young ages, leukemias are more likely to be of the acute rather than chronic type. In terms of cell of origin, they can be lymphoid or myeloid, so most of the time at this age it will be acute lymphoid (lymphoblastic, all) or acute myeloid leukemia (aml). Chronic myeloid leukemia (CML) is also possible but not as common.See 2 more doctor answers
More intensive chemo: Yes, chemotherapy regimens for pediatric acute leukemia are usually much more intensive and the dose usually is higher than the chemo for adult patients. Children are much tougher than how they look. They get higher dose of chemo and more intensive, but they tolerate them very well and would bounch back right away.
Combination chemo: The drug choicees are variable among different age groups. Children with ALL are commonly treated with Vincristine/ Prednisone initially and later receive 6MP and Methotrexate. In adults we tend to use Cyclophosphamide, Adriamycin (doxorubicin) vicristine and Dexamethasone. L-Asparaginase is commonly used but only in children. In Ph+ve patients Imatinib is added as well.
Yes: Relapse is certainly possible. Also, secondary cancers are unfortunately common as well.
All leukemia types..: May be cured in some people but not in others. Factors which make leukemia very high risk and less likely to be cured include certain chromosomal aberrations, abnormal (dysplastic) shapes of the leukemia cells, and old age of the patient. To be more precise one must first determine which kind of leukemia we are dealing with.
Blood cancer: Leukemia is a cancer of the white blood cells and bone marrow is the site of the defect. Treatment and outcome depend on the type of leukemia and stage of the disease. Some leukemias may be curable with intensive therapy and may require bone marrow transplantation.See 1 more doctor answer
Cures in Leukemias: CLL is usually managed by watchful waiting. CML can be held back with lifelong tyrosine kinase inhibitors, but the leukemia recurs in most pts if drug stopped. Children with ALL can be cured, but adult ALL is difficult to cure. A minority of AML can be cured with chemo (APL, CBF AML). Allogeneic transplant can be curative, but is risky. Cure depends on the individual's leukemia genetics, etc.
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