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Doctor insights on: Which Is Better For Sleeping Mirtazapine Or Amitriptyline

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Is there a difference between mirtazapine and amitriptyline in terms of effectiveness for pain and sleep?

Is there a difference between mirtazapine and amitriptyline in terms of effectiveness for pain and sleep?

No direct answer: These are 2 different drugs. Again, there is "no better than" or "as good as". Treatment of any disorder should be individualized. I would think that Remeron (mirtazapine) is more often prescribed for sleep disorders where as Amitriptyline is more often prescribed for pain when talking about these 2 conditions specifically. ...Read more

Dr. Bernard Seif
381 Doctors shared insights

Mirtazapine (Definition)

Mirtazepine (remeron) is a noradrenergic/specific serotonergic antidepressant [nassa]. It is used for major depressive d/o, various anxiety disorders, chronic pain, and others. In some, it can help ssri-induced sexual dysfunction & "poop out." it can be sedating and also increase appetite -- good for some ...Read more


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Does elavil or tofranil help with sleep along with depression thinking of changing my remeron (mirtazapine) because still depressed and massive weight gain?

Does elavil or tofranil help with sleep along with depression thinking of changing my remeron (mirtazapine) because still depressed and massive weight gain?

Elavil? Remeron (mirtazapine)?: Elavil (amitriptyline) and tofranil (imipramine) are both sedating antidepressants. These can also contribute to weight gain, however. It is essential to speak with your prescribing doc so you can discuss your current sxs and side effects and determine the best plan for you going forward. ...Read more

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I am on sertraline 100 mg I have stopped taking the amitriptaline and mirtazapine could you recommend what I could take to help with sleep problems?

I am on sertraline 100 mg I have stopped taking the amitriptaline and mirtazapine could you recommend what I could take to help with sleep problems?

Work w/ your Dr: Ever a good idea to stop psych meds w/out professional guidance. Work together to find the right plan for you and add CBT theapy to optimize effects as well as learning skills to better life. This will include sleep skills! Best wishes. ...Read more

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Can I take amitriptyline 20mg and mirtazapine 15mg?

Can I take amitriptyline 20mg and mirtazapine 15mg?

Were they both: Prescribed to be used at the same time for you? Mixing these two medications may increase risk for serotonin syndrome. However, that does not mean that one will of necessity have this side effect. ...Read more

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Dr gave me amitriptyline 50 mg 1 a day & gave me remeron (mirtazapine) 15mg 1day, im allergic to vistaril does remeron (mirtazapine) have that in it. And which 1 is better to use?

Dr gave me amitriptyline 50 mg 1 a day & gave me remeron (mirtazapine) 15mg 1day, im allergic to vistaril does remeron (mirtazapine) have that in it. And which 1 is better to use?

Different drugs: Benadryl, (diphenhydramine) Remeron &amitriptyline can all have the side effect of sedation & each is sometimes prescribed for use as as sleep aid rather than their primary clinical benefit for allergy related symptoms (Benadryl) & antidepressant (Remeron & Amitriptyline). But they are differ in how they are constructed chemically or in the way they work. You & your doctor can decide which medivine may be best. ...Read more

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Would smoking a small amount of weed be safe (for nerve pain) be ok with other meds I'm taking. Amitriptyline, mirtazapine, venlafaxine?

Would smoking a small amount of weed be safe (for nerve pain) be ok with other meds I'm taking. Amitriptyline, mirtazapine, venlafaxine?

Most likely.: While federal regulations prohibit me from recommending the use of schedule I medications such as cannabis I can tell you that there is overwhelmingly scant evidence that its consumption with the drugs that you listed would be risky. That said IF you were to consume it any option other than burning it to ingest it would be preferable: i.e. consider an edible, atomized or nebulized form. ...Read more

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Besides remeron, (mirtazapine) what other med is good for sedation and anxiety? Trazodone gives me terrible nightmares & elavil is evil to get used to.

Besides remeron, (mirtazapine) what other med is good for sedation and anxiety? Trazodone gives me terrible nightmares & elavil is evil to get used to.

Buspar (buspirone) is another: Buspar (buspirone) is a non-addictive anti-anxiety medication. Studies have also shown that approximately 70% of individuals taking anti-anxiety medications can learn to manage anxiety without medication with a course of focused cognitive-behavioral treatments by a psychologist. ...Read more

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My Dr put me on 10mg elavil a tricylic antidepressants. I am Lexapro (escitalopram) 20mg and remeron 30.mg. I suffer from G A D.Are these o k together. Thanks?

My Dr put me on 10mg elavil a tricylic antidepressants. I am Lexapro (escitalopram) 20mg and remeron 30.mg. I suffer from G A D.Are these o k together. Thanks?

Not recommended...: The Mirtazapine (Remeron) is fine. Elavil (amitriptyline) oral and Lexapro or escitalopram oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock.
...Read more

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I needed a second opinion. Is it safe to taper off remeron (mirtazapine) 15mg to 7.5mg while increasing a new antidepressant elavil 12.5mg to 25mg at same time?

Yes, it's safe: It's possible to safely "cross-taper" medications like this -- meaning to lower and stop one while gradually raising the other. Remeron (mirtazapine) and Elavil will be fine in this way, and hopefully the Elavil will be helpful by itself. Be well, . ...Read more

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I am taking elavil, nuvigil, remeron, and Xanax (alprazolam) for anxiety/depression/chronic daily fatigue. The first 3 have me in a fog. Will weaning off help me?

I am taking elavil, nuvigil, remeron, and Xanax (alprazolam) for anxiety/depression/chronic daily fatigue. The first 3 have me in a fog. Will weaning off help me?

Yes: Weaning off medication may help. Nuvigil is not usually sedating or causing "fog", the three other medications could. Discuss adjusting medication with treating physician, it is not safe to abruptly stop all of these medications. ...Read more

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Hi, I want to come off mirtazepine and go back on amitriptyline due to weight gain. I can't see my Drfor ages. Please can you advise?

Hi, I want to come off mirtazepine and go back on amitriptyline due to weight gain. I can't see my Drfor ages. Please can you advise?

NEED DOCTOR: This is a problem because you will need a doctor to help the shift. Cannot advise without knowing the doses etc. Best to go slowly whatever you do. ...Read more

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Is it okay to use endep (amitriptyline) for sleep?

Is it okay to use endep (amitriptyline) for sleep?

Off label use: Amitriptyline (Endep) is often used off -label for the treatment of insomnia. ...Read more

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I've taken 40mg of amitriptyline, will it help me sleep?

I've taken 40mg of amitriptyline, will it help me sleep?

Elavil (amitriptyline): It often does but not always. Getting sleepy is a side effect of this older antidepressant and the dose is from 10mg to 150 mg a day usually. ...Read more

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Is it okay to take toviaz (fesoterodine) during the day for urinary urgency and frequency and then amitriptyline at night for sleep?? Can they be taken together?

Is it okay to take toviaz (fesoterodine) during the day for urinary urgency and frequency and then amitriptyline at night for sleep?? Can they be taken together?

See my remark: Toviaz (fesoterodine) is a once daily use as a anticholenergic -used for overactive bladder-
You can use Amitryptyline at night don't make it routine ...Read more

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I get sever migraines that last up to 3 weeks, they are in the front wake me from my sleep im confused tired im not as hungry and they are very sudden I take amitriptyline hcl 50 mg everynight but they keep getting worse?

I get sever migraines that last up to 3 weeks, they are in the front wake me from my sleep im confused tired im not as hungry and they are very sudden I take amitriptyline hcl 50 mg everynight but they keep getting worse?

Chronic headaches: Can be treated in various ways at headache clinics at some local hospitals. Your doc may refer you or search one out yourself. You can also consider natural approaches such as a food sensitivity panel from Great Plains Laboratory in KS. Peace and good health. Biofeedback and clinical hypnosis (www. Asch. Net for referrals) are also possibilities. ...Read more

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Is amitriptyline used to help sleep?

Is amitriptyline used to help sleep?

Sometimes: It can definitely aid in sleeping as it has significant drowsy side effects, but is usually prescribed to help with another condition like chronic fibromyalgia pain or other neurological pain like migraines sometimes with the added benefit of also helping you sleep. I'm sure there are some doctors out there who may prescribe it for the sole purpose of being a sleep aid. ...Read more

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Expert opinions? Which is more sedating mirtazapine or amitryptaline?

Expert opinions? Which is more sedating mirtazapine or amitryptaline?

Roughly equal: This kind of question is hard to answer, as it depends on the dosage of each. Mirtazepine (brand name remeron) is probably better tolerated overall, although it's well-known to cause weight gain. Amitriptyline (brand name Elavil (amitriptyline) ; others) has more dry mouth, constipation, ; orthostasis (dizziness when standing), but can be quite effective if these aren't a problem for an individual patient. ...Read more

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I was just prescribed Amitriptyline for aiding sleep and was wondering what the difference is from Ambien (zolpidem) which I used to be prescribed.

I was just prescribed Amitriptyline for aiding sleep and was wondering what the difference is from Ambien (zolpidem) which I used to be prescribed.

New medicine: This medicine works differently than ambien (zolpidem). For that reason, it may work better or worse for you. It can cause you to feel sleepy. It can also cause a feeling of a dry mouth or light headedness. It is used often in Neurology to prevent headaches or for nerve pain also. ...Read more

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How to counteract the effect of elavil (amitriptyline) on rem. Sleep?

How to counteract the effect of elavil (amitriptyline) on rem. Sleep?

Not take it?: The ongoing use of Amitriptyline likely is disrupting to your sleep architecture. You could try melatonin to try to normalize your rem sleep or talk to you doctor about rozerem (ramelteon). The only other medicines that might help are for dementia or parkinson's disease. I notice you are taking Aripiprazole and mirtazpine and, these are also likely contributing to your rem disturbance. Talk to your md! ...Read more

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Is elavil (amitriptyline) supposed to be taken for sleep, for depression, or for pain?

Is elavil (amitriptyline) supposed to be taken for sleep, for depression, or for pain?

Elavil (amitriptyline): Elavil (amitriptyline) may be used for pain and depression, one of the side effects is somnolence so it helps with sleep problems as well. ...Read more

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My doctor gave me amitriptyline to help me sleep. Should it help right away or does it have to build up in my system?

My doctor gave me amitriptyline to help me sleep. Should it help right away or does it have to build up in my system?

Be patient: It can work right away in some, but not usually, it can take up to a couple of weeks to take full effect. ...Read more

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Take Xanax (alprazolam). 5 mg & amitriptyline 12.5mg HS for sleep. Is it ok to take st johns wort in the morning to help with positive mood?

No.: St. John's Wort hastens the breakdown of Amitriptyline and taking both will be counterproductive. If you still need something to make you feel positive, go back to your doctor and have him reevaluate your medications. ...Read more

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I've taken 7.5mg zopiclone + 5mg Valium & 2 x 30/500 cocodamol for sleep but it is ineffective. I've now had amitriptyline & tramadol. Is this safe?

I've taken 7.5mg zopiclone + 5mg Valium & 2 x 30/500 cocodamol for sleep but it is ineffective. I've now had amitriptyline & tramadol. Is this safe?

Not Safe!: It is never safe to combine these medications. Talk to your doctor about your insomnia. You need a careful evaluation in order to obtain an accurate diagnosis and appropriate treatment. Polypharmacy is never safe! We lose too many young people each year due to unintentional overdose. Be safe and work with your doctor. ...Read more

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Is elavil (amitriptyline) safe to use for sleep? Is it safe to use in someone who has bipolar disorder?

Is elavil (amitriptyline) safe to use for sleep? Is it safe to use in someone who has bipolar disorder?

Elavil (amitriptyline) is of course: An antidepressant. Antidepressants might potentially flip someone with bipolar disorder into mania or hypomania. Therefore it wouldn't be my first choice of medications to aid with sleep. Take care. ...Read more

Dr. Heidi Fowler
5,032 Doctors shared insights

Sleep (Definition)

Sleep is a topic that involves concepts such as how long it takes to fall asleep, how many times one wakes up at night, how many hours one sleeps at night, sleep stages, ...Read more


Dr. Jeffrey Satinover
379 Doctors shared insights

Elavil (Definition)

Elavil is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more