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Doctor insights on: Which Infections Have An Elevated Ch50

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Which infections have an elevated ch50?

Which infections have an elevated ch50?

Complement: Total hemolytic complement (ch50) is the best functional assay of the complete complement sequence. Ch50 is often decreased in sle, glomerulonephritis and other immune complex diseases. A normal ch50 level indicates that all the components, c1 through c9, are present. However, individual complement factors may be depleted 50 to 80% without affecting ch50. Non-specific ; when elevated non-diagnositic. ...Read more

Dr. Herman Hammerstead
9 Doctors shared insights

Infection (Definition)

Infections are invasions of some other organism (fungus, bacteria, parasite) or viruses into places where they do not belong. For instance, we have normal gut bacteria that live within us without causing problems; however, when those penetrate the bowel wall and enter the bloodstream, ...Read more


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Had a colonoscopy 6 months ago pain in transcending and sigmoid and anal and rectum. Ct showed Diverticulosis. I also have a high ch50. Infection?

Had a colonoscopy 6 months ago pain in transcending and sigmoid and anal and rectum. Ct showed Diverticulosis. I also have a high ch50. Infection?

Can't be sure: Diverticulosis does not cause pain, but diverticulitis would (leaking of intestinal content internally). High CH50 means that the "classic and terminal" features of the complement system (innate arm of the immune system) are working beautifully. Low CH50 might be noteworthy, but usually this only occurs when the system needs to be replenished after an illness. Need much more info to address pain. ...Read more

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If complement c3, ch50, serum protein electrophoresis, and immunofixation suggest severe infection, why is CBC normal? I've never had blood culture.

If complement c3, ch50, serum protein electrophoresis, and immunofixation suggest severe infection, why is CBC normal? I've never had blood culture.

Lab data: Without placing values in a clinical context with full history, exam and all data it is pointless to speculate. You need to be evaluated by a physician and if the one you are seeing cannot provide answers, get a second opinion. Try seeing an infectious diseases expert. ...Read more

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Low c3 (normal c2, c4, ch50), low igg1, low igg3, low total igm. Doc says all r acquired. He suspects cancer, autoimmunity, or infection. Is he correct?

Low c3 (normal c2, c4, ch50), low igg1, low igg3, low total igm. Doc says all r acquired. He suspects cancer, autoimmunity, or infection. Is he correct?

Difficult to tell: Without any context, it is very difficult to interpret laboratory results. More information about why these particular tests were done would be helpful. ...Read more

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My LLD told me that all blood work was normal-excpt my C3 & C4 levels were low. My online paperwork shows high Ch50 too. Two years ago, he said the Ch50 was high too. My issue has been recurring minor sinus infections with a mold allergy...thoughts?

My LLD told me that all blood work was normal-excpt my C3 & C4 levels were low. My online paperwork shows high Ch50 too. Two years ago, he said the Ch50 was high too. My issue has been recurring minor sinus infections with a mold allergy...thoughts?

Autoimmune?: The low C3 and C4 levels suggest the presence of an inflammatory process which is likely of autoimmune origin. The elevated CH50 also supports the presence of inflammation such as infection. With your frequent sinus infections, an immune evaluation is indicated since immunodeficiency is often associated with autoimmune disorders Consult an allergist/immunologist. ...Read more

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Can low t-3 and elevated ESR be an infection?

Can low t-3 and elevated ESR be an infection?

Likely unrelated: The two test results are likely to be unrelated. Esr may be high in an infection. All lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. ...Read more

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Can an elevated IgM be caused by an infection?

Can an elevated IgM be caused by an infection?

Possibly: An elevated igm could be benign or the sign of a more seious issues. Probably best to discuss with your doc. ...Read more

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Can someone explain to me how come someone have an elevated aso titer if there is no g.A.S infection present?

Statistics: Titer defined as positive is a statistical value. To reduce false negatives, a certain percentage of false positives will be found. Additionally, the aso witnesses past exposure, not necessarily infection. ...Read more

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My son keeps having reocurring fevers and recently had elevated inflamatory markers with no infection. What could be causing that?

My son keeps having reocurring fevers and recently had elevated inflamatory markers with no infection. What could be causing that?

AUtoimmune: As infections are ruled out, the next concern would be an autoimmune disease. Discuss with your doctor about what symptoms may be compatible with what syndrome; it is far too detailed a discussion to have here. ...Read more

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What does an elevated both white and red blood count mean? Do red cell counts rise during infections?

What does an elevated both white and red blood count mean? Do red cell counts rise during infections?

Leucocytosis: Elevated white cell count can represent many maladies in many people both male and female and also be normal in certain circumstances-like in labor! it can also be normal for certain people. Yes it does go up in infections -that being the most common condition for leucocytosis. It can also be a red flag for leukemia or other body area cancers. No-red cells do not commonly go up in infections! ...Read more

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Do all infections cause a elevated wbc?

Do all infections cause a elevated wbc?

Not all: In some cases they are not affected at all and or they can cause a decrease in the WBC count. (usually a very bad sign). ...Read more

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Can periodontal infection cause elevated sed rate?

Depending on the: Severity / extent and duration of the periodontal disease / infection it would seem possible to have an elevated esr. Best to be evaluated by a dentist to rule out dental / periodontal etiology. Hope this helps. ...Read more

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Is it possible to have an infection without an elevated wbc?

Yes.: Many mild infections do not affect the wbc. More severe infections typically elevate the wbc. Infections can occur when WBC is low. ...Read more

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Do all infections cause a elevated wbc? Or only the bad infections do

Some do, some don't: It's just one piece of information. Most severe bacterial infections will raise the neutrophil count and put overactive and young cells in that series into the blood -- but the very worst may actually feature a low count. Different white cells come out for different knids of infection, and sometimes the response is poor overall. Don't rely on just one piece of information. ...Read more

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What if your immunoglobulin m is elevated? Does it mean an infection?

What if your immunoglobulin m is elevated? Does it mean an infection?

Depends: Igm & ige are the first antibodies to rise in the face of infection. As the body refines its immune response IgA & igg antibodies specific for the infecting agent are produced while specific IgM levels fall. Rarely does the IgM response to an infection raise the total amount of igm. Exceptions are congenital infections. High total IgM in adults suggest autoimmune disease or malignancy. ...Read more

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My WBC is always elevated even if there's no focus of infection found. What's wrong with me?

Probably nothing: As a pathologist, I'm always telling folks to treat people, not lab numbers. Some folks naturally run a high absolute count of one or another kind of white cell, without there being any obvious abnormalities. It's something to know for "baseline." best wishes. ...Read more

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Why is the risk elevated for staphylococcus aureus infection for those on home parenteral nutrition?

Risk of infection: The risk resides with the insertion site of the intravenous catheter. The insertion site is a breach of skin where skin bacteria can gain entrance into the vein. Staph is a skin bacteria. Hence, controlling infection risk requires strict technique and extreme carefulness at the catheter site. Wearing gloves. Purell, Extreme caution with connections. ...Read more