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Doctor insights on: When Zoloft Stops Working

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Could Zoloft (sertraline) stop working?

Potentially: Agree with Dr. Jacobson. Some people may develop SSRI poop out on Zoloft and other SSRI's.

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Dr. Heidi Fowler
1,081 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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I've been taking 100mg Zoloft for depression, anxiety, and to stop my suicidal thoughts. It was working fine for months but about 3 weeks ago it seemed to stop working. At this point it is barely working at all. I did start smoking pot about a month ago f

I've been taking 100mg Zoloft for depression, anxiety, and to stop my suicidal thoughts. It was working fine for months but about 3 weeks ago it seemed to stop working. At this point it is barely working at all. I did start smoking pot about a month ago f

Ans: Get off that pot. If you have a clinical depression take your Zoloft (sertraline). If you just can't cope with life the Zoloft (sertraline) will not help you and you should get counseling. The thc will only give you more problems. If you truly need help get it and learn your coping skills not an escape with the thc

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I have severe OCD of health issues and am also facing an auto immune diagnosis I can't stop crying and basixally planning my funeral I have tried Zoloft (sertraline) and Prozac nit working any advice?

I have severe OCD of health issues and am also facing an auto immune diagnosis I can't stop crying and basixally planning my funeral I have tried Zoloft (sertraline) and Prozac nit working any advice?

Talk w/therapist: First, you need to know that an autoimmune diagnosis can be serious, but is not an automatic death sentence. Second, please know that medications do not replace the benefit of talking regularly with a skilled psychotherapist -- you should look for one who's comfortable with people going through medical procedures & what that's like. This could certainly be a psychiatrist if s/he does therapy!

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What happens if you stop taking Zoloft (sertraline) suddenly?

What happens if you stop taking Zoloft (sertraline) suddenly?

Discontinuation: If stopped, most antidepressants will cause discontinuation symptoms. Rarely dangerous (but somewhat worrysome), they are the reason why whenever possible is better to taper off slowly. Dizziness, anxiety, lightheadedness, and cold-like symptoms are the most classic presentation. Ask your dr before thinking of stopping meds.

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Should I stop if Zoloft (sertraline) is causing unreality feeling?

Should I stop if Zoloft (sertraline) is causing unreality feeling?

You should let your: Psychiatrist/ prescribing provider know asap. If this is the cause - the provider is likely to work at tapering you off and would likely consider a different medication.

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Have been on 25 mg of Zoloft (sertraline) for two weeks. When do I stop taking it?

Consult with dr.: Are you tapering off the zoloft (sertraline) or did you just start it? This clearly needs to be done under your providers supervision but with a taper this long, it can usually be stopped.

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How can I stop taking zoloft (sertraline)? I'm on 50mg have been using it for 9 months?

How can I stop taking zoloft (sertraline)? I'm on 50mg have been using it for 9 months?

Under supervision: Discuss it with your physician to see what is safest for you. However 50mg is low enough to stop it without having to decrease the dose.

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How long does it take for Zoloft (sertraline) to leave your system after you stop taking it?

5 days: 1/2 life is 1 day, 5 half life's to clear. Assuming you are a normal metabolier 5 days would pretty much do it.

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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I feel like I've lost myself while being on Zoloft (sertraline) but I can't stop taking it what should I do?

Dr. Alan Ali Dr. Ali
1 doctor agreed:

Zoloft (sertraline): Not sure what dose u r taking & whether your symptoms started after increasing the dose, but I recommend reviewing those possibilities with your prescribing doctor to see if lowering the dose might be an option.

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How long should it take to stop having side efx of Zoloft (sertraline) after discontinuing. I have taken 100 mg for 5 days.

How long should it take to stop having side efx of Zoloft (sertraline) after discontinuing. I have taken 100 mg for 5 days.

Best to work w/ Dr: Discontinuation of these drugs is best done w/ a medical -guided taper but if you can not do that, watch for changes and read advice here (good diet idead - search for Omega): http://www. Steadyhealth. Com/Zoloft_cold_turkey_t93900.html It can take up to a month, so be patient. It may be less - so be hopeful. Ask 1st about risks. Take care. Try Tx.

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I've been on 50mg Zoloft (sertraline) for a few months and would like to stop. Do I have to go down to 25mg or can I just stop it altogether right now?

Ask your physician: Sally, it is never a good idea to stop psychiatric medications on your own. You can have physical withdrawal symptoms in addition to mood changes and increased anxiety if medication changes are not done carefully. Please ask your psychiatrist about this, and share with him/her WHY you would like to come off of the medication.

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Been taking Zoloft (sertraline) for a few months and piled on the pounds and my trousers don't fit unless elasticated so will I loose it if I stop the drug?

Been taking Zoloft (sertraline) for a few months and piled on the pounds and my trousers don't fit unless elasticated so will I loose it if I stop the drug?

Zoloft (sertraline) weight gain: Review your weight gain with prescribing doctor to make sure there is no other explanation. If all points to Zoloft (sertraline), (sertraline) discuss switching to another med not likely to cause weight gain. Weight gain should slowly reverse when Zoloft (sertraline) is stopped. Be sure to eat healthy and exercise as best you can. Good you're questioning the weight gain. All the best.

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I take Zoloft (sertraline) 25mg they are making me feel worst after 3 months today I woke up out of my body not feeling myself what do I do? How do I stop this?

I take Zoloft (sertraline) 25mg they are making me feel worst after 3 months today I woke up out of my body not feeling myself what do I do? How do I stop this?

Work w/ your Dr: Tell the Dr about this ASAP and if they are not a psychiatrist - get a referral to a psychotheapist and/or psychiatrist. They can taper you off this safely (impt!!) and either try talk therapy alone or w/ another drug. Don't just quit! It can be risky - but call the Dr now!

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Can I safely stop taking Zoloft (sertraline) cold turkey?

Can I safely stop taking Zoloft (sertraline) cold turkey?

It's safe....but: It is safe but you might experience some disconinuation sx--dizziness flu like symptoms some pts describe electric "zaps" in their heads-- probably better to wean off gradually.

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I'm currently taking Zoloft, 50 mg. I want to stop so how do I slowly taper?

Slow taper: The ideal route would be to reduce it to 25 mg for 5 days, then take it alternate days for 3 days, then stop.

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What side effects would you experience if you suddenly stop taking zoloft (sertraline)?

What side effects would you experience if you suddenly stop taking zoloft (sertraline)?

Check out these: Links. God bless u! http://www. Healthline. Com/health/depression/dangers-of-stopping-antidepressants? toptoctest=expand. Http://www. Doctoroz. Com/videos/best-natural-anti-depressants? Page=3.

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Hello, I m taking Zoloft (sertraline) since 6 months, I want to stop but afraid from side effects.

Hello, I m taking Zoloft (sertraline) since 6 months, I want to stop but afraid from side effects.

Talk w/your doctor: Talk with your doctor about how you're feeling. The 2 of you can discuss the reasons zoloft (sertraline) was prescribed in the first place, and whether it's safe and reasonable to taper it now. If it is, your doctor can work with you towards this goal.

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I've been taking Zoloft (sertraline) 50mg for over a year if I stop slowly will the symptoms come back?

I've been taking Zoloft (sertraline) 50mg for over a year if I stop slowly will the symptoms come back?

It depends: It really depends what you are taking zoloft (sertraline) for: depression, anxiety and etc. It also matters what other treatments you are exploring for your symptoms or condition. I would recommend that you consult a psychiatrist to determine if that is the time when you could taper your medication safely. Everyone is different, so personalized approach really matters.

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I would like to stop taking my Zoloft (sertraline) (it was for my anxiety). What is the best way to quit?

Talk with provider: Coming off Zoloft (sertraline) too quickly can produce withdrawal so please make sure you talk with your prescribing provider about how to taper off the medication. Not only is this important for effective communication about your healthcare and treatment planning, but your provider can best advise you on stopping based on your health history and dosage. Be well.

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Is it true that you have to stop taking Zoloft (sertraline) one week prior to having cellulaze. If so, why?

Investigating: I am not acquainted enough with cellulaze to know of an interaction. I have sent a curbside consult to my colleagues to investigate... In the process, take care of yourself:).

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Dr. Heidi Fowler
1,036 Doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more