Top
10
Doctor insights on: What Type Of Mutation Causes Sickle Cell Anemia

Share
1

1
Can you explain to me how mutation take place in sickle-cell anemia?

Can you explain to me how mutation take place in sickle-cell anemia?

Important gene...: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease. ...Read more

Mutation (Definition)

In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more


2

2
What causes sickle cell anemia besides malaria?

What causes sickle cell anemia besides malaria?

Malaria doesnt cause: Sickle cell anemia is a hereditary disease caused by a mutation in the dna coding for hemoglobin. Scientists have long known that sickle cell anemia protects carriers from malaria infections, which could be advantageous in certain parts of the world. Malaria does not cause sickle cell anemia. ...Read more

See 1 more doctor answer
3

3
What cause the symptoms of sickle cell anemia?

What cause the symptoms of sickle cell anemia?

Symptoms of SS: The altered shape of the red blood cells causes them to stack up together and clog blood vessels, depriving the tissues of adequate blood supply and oxygen. The tissues then die (infarct) and this causes pain. The red cells also rupture or are eaten by the spleen and cause anemia. The spleen itself will gradually infarct, leaving the patient susceptible to infections. ...Read more

4

4
Please tell me the cause of sickle cell anemia?

Please tell me the cause of sickle cell anemia?

Stiffened hemoglobin: There is a genetic change that causes an abnormal hemoglobin. This abnormal hemoglobin becomes stiff in certain circumstances, causing the red blood cell to sickle. This causes many symptoms, including anemia, pain, and many other symptoms. ...Read more

5

5
What is the cause of sickle cell anemia in fetus?

What is the cause of sickle cell anemia in fetus?

You may be confused.: Fetuses do not suffer from sickle cell anemia in utero because they have a different type of hemoglobin (fetal) that is unaffected even in individuals destined to have sickle cell disease later in life. Affected fetuses come from affected or carrier parents and sickle cell disease is a genetic condition without cure at present. See a genetic counselor to discuss these issues in detail. ...Read more

6

6
How/why does sickle cell anemia cause problems when under anaesthetics?

How/why does sickle cell anemia cause problems when under anaesthetics?

Increased sickling: Multiple factors can result in increased sickling during anesthesia and surgery. Chemical changes in the acidity of the blood, oxygen carrying capacity of the blood, body temperature, etc all increase the risk of sickling. Therefore transfusions are strongly recommended prior to surgery to reduce the total number of red cells with hemoglobin s prior to surgery in an attempt to minimize the risk. ...Read more

See 2 more doctor answers
7

7
How does sickle cell anemia cause complications when under anesthetics?

How does sickle cell anemia cause complications when under anesthetics?

Compromising organs: Sickling of the red blood cells can occur from stress or ketoacidosis (diabetes out of control) and causes of low oxygen in the lungs or blood. This will cause the sickled cells to obstruct the flow of the cells that still are able to carry oxygen to the various organs such as the liver, the brain, heart, muscles and any and all tissue. This compromises function of the organ or tissue. ...Read more

8

8
What can cause the symptoms of sickle cell anemia?

What can cause the symptoms of sickle cell anemia?

Anemia itself : Causes some symptoms. Sickle cells can decrease flow to organs and lead to bone pain and chest syndrome. ...Read more

9

9
What are the different types of sickle cell anemia?

What are the different types of sickle cell anemia?

Types os SIckle Cell: From nih, division of blood diseases and resources: sickle cell disease-ss: 65% of us patients; genotype s/s sickle cell disease-sc: 25% of us patients; genotype s/c sickle cell disease-s beta + thalassemia: 8% of us patients; genotype betas/ beta + thalassemia sickle cell disease-s beta 0 thalassemia: 2% of us patients; genotype betas/ beta 0 thalassemia. ...Read more

See 1 more doctor answer
10

10
What is the blood type given to those who have sickle cell anemia?

What is the blood type given to those who have sickle cell anemia?

Same rules...: If a person with sickle cell disease requires a transfusion, the rules governing which blood types are safe are the same as for the general population. ...Read more

Dr. James Ball
348 doctors shared insights

Sickle Cell Disease (Definition)

This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more


Dr. Steven Ginsberg
1,236 doctors shared insights

Anemia (Definition)

Anemia refers to any condition where there is a decrease in the red blood cells in the body. There are numerous causes of anemia but they can basically be broken down into 3 categories: decreased production of red blood cells increased destruction of red ...Read more