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Doctor insights on: What To Do After Positive Ana Test

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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Is their any other tests to get diagnosis for my case after positive ANA test, leukocytosis, sever joint pain and itchy skin patches ?

Is their any other tests to get diagnosis for my case after positive ANA test, leukocytosis, sever joint pain and itchy skin patches ?

Positive ana: There are many other tests that can help confirm a diagnosis. Additional blood tests to determine the exact antibody that is causing the positive ANA should be done. A skin biopsy may be indicated. It is possible that your doctor has already arrived at a diagnosis from your constellation of symptoms. ...Read more

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What does a positive ANA test mean?

What does a positive ANA test mean?

Antibodies vs nuclei: The titer (how much antibody power is present) is important -- 1:40 seldom means much, 1:320 would worry most folks -- as does the pattern, but like all lab tests, its meaning comes from the setting. Typically a screen for lupus and related diseases, many older folks who are healthy run a low titer. ...Read more

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What does a positive ANA test mean?

What does a positive ANA test mean?

Antibodies vs nuclei: The titer (how much antibody power is present) is important -- 1:40 seldom means much, 1:320 would worry most folks -- as does the pattern, but like all lab tests, its meaning comes from the setting. Typically a screen for lupus and related diseases, many older folks who are healthy run a low titer. ...Read more

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What do you suggest if positive ANA test, what does this mean?

What do you suggest if positive ANA test, what does this mean?

Many reasons: Although the + ANA is a screening test for lupus erythematosus. But most people with a + ANA do not have lupus. We see it in a lot of conditions including, thyroid disease,allergic conditions, liver disease, other connective tissue etc. Your physicians can have you see a rheumatologist to clarify why you have a + ANA and whether you have lupus or another connective tissue disea ...Read more

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2 positive ANA titres 1:160 speckled. All manual diff tests neg. Is this something to worry about?

May be non-specific?: ANA is test for antibodies directed against nuclear antigens. A positive test screens for autoimmune diseases such as systemic lupus erythematosus. There are four patterns: homogenous, nucleolar, peripheral, and speckled. Low titers less than 1:160 is likely a non-specific response. The clinical importance of this is to be decided in the light of other findings, and a follow-up test for direction. ...Read more

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I have a positive ANA test but it reads as 6? I'm used to seeing them as 1:40, 1:80 etc... What does 6 mean?

Possibly nothing: This is certainly non-standard reporting. It suggests that on cannot have confidence in the reporting laboratory and the test should be repeated elsewhere. ...Read more

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I recently got a positive ANA test 1:80 homogenous with no other symptoms. What does this mean? 32 yrs old healthy.

Positive ana: 1:80- not that high. Worry if > 1:160.Ana tests for autoimmune disease. In recent study ~13% of well blood donors had + ana with no symptoms, of those, 72% did not develop any issues with ~ 4 years of follow up. Sometimes other conditions like thyroiditis, mono, chronic disease,multiple sclerosis can cause positive ana as can meds :INH,hydralazine,procainamide remicade (infliximab). FU with rheumatologist. ...Read more

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Can syphilis cause a positive ANA test?

No: However lupus can cause the screening test for syphilis (the rpr) to be falsely positive. ...Read more