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Doctor insights on: What Percent Of Women Inherit A Brca1 Or Brca2 Gene

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Dr. Romeo Mandanas Dr. Mandanas
Internal Medicine - Hematology & Oncology
34 years in practice
Cebu Institute of Medicine
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What percent of women inherit a brca1 or brca2 gene?

What percent of women inherit a brca1 or brca2 gene?

Clarifying Q & A: In the general population, the incidence of a brca1 mutation is between 1:500 to 1:800. It is much lower for brca2. For a woman or offspring to inherit the gene from a parent who has one copy of the mutated gene, there is a 50% chance of acquiring the gene in question. It is autosomal dominant and therefore can manifest its deleterious consequences by itself without need of a second copy. ...Read more

Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


Dr. Yash Khanna Dr. Khanna
Family Medicine
53 years in practice
University of Lucknow, K. G. Medical College
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Any stats on how many woman have been tested for the brca1 and brca2 gene?

Any stats on how many woman have been tested for the brca1 and brca2 gene?

Brac1 and brac2 gene: No nobody keeps track of that because these tests are done all over the world. ...Read more

Dr. Stevan Cordas Dr. Cordas
Internal Medicine
53 years in practice
Philadelphia College of Osteopathic Medicine
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What does the brca2 gene mean as a guy?

What does the brca2 gene mean as a guy?

BRCA2: Such men carry increased risk for breast and prostate cancers and should follow up with a specialist. ...Read more

Dr. Yash Khanna Dr. Khanna
Family Medicine
53 years in practice
University of Lucknow, K. G. Medical College
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If my mom has the brca2 gene but I don't, can insurance companies charge me more?

If my mom has the brca2 gene but I don't, can insurance companies charge me more?

Brac2gene: No that can not charge you more.Is your question about life insurance or medical insurance.Whatever you are negative for this gene and there should be no risks. ...Read more

Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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What is the definition or description of: brca2 gene?

What is the definition or description of: brca2 gene?

Cancer risk locus: This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make decisions to protect health. ...Read more

Dr. Addagada Rao Dr. Rao
Surgery
52 years in practice
Andhra University, Guntur Medical College
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Does the brca2 gene also cause colon cancer? Or just breast and ovarian?

Does the brca2 gene also cause colon cancer? Or just breast and ovarian?

BRCA for breast: Brca genetic mutations are for breast and ovarian cancers , for for colonic cancers apc gene, & familial non polyposis gene mutation are tested. 75% of colon cancers has no family history, best way to detect early is by regular doctor visits and colonoscopic examinations for early detection and cure. ...Read more

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Dr. Anthony Filly Dr. Filly
Radiology
22 years in practice
Wake Forest University School of Medicine
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Can u still have endometriosis or ovarian cancer w/ a clear transvaginal ultrasound? My doc says my ovaries are normal and my tiny cyst is gone. I have tons of pelvic pain & my mom has the brca2 gene.

Can u still have endometriosis or ovarian cancer w/ a clear transvaginal ultrasound? My doc says my ovaries are normal and my tiny cyst is gone. I have tons of pelvic pain & my mom has the brca2 gene.

Yes and No: Yes: you could definitely have endometriosis with a clear ultrasound, but would not likely have an endometrioma of the ovary no: it would be pretty unlikely to have ovarian cancer with a clear ultrasound and even if you did have extremely early undetectable cancer, it would not cause pain. ...Read more

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Dr. Haluk Tezcan Dr. Tezcan
Internal Medicine - Oncology
31 years in practice
University of Istanbul Faculty of Medicine
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Are genetic tests available to detect brca1 and brca2 mutations, and how are they performed?

Yes: Brca1 and 2 mutation analysis is performed at myriad lab in usa. One can either use an oral swab or blood for testing. It is strongly recommended that the testing is done in the context of genetic counseling as the interpretation of the test and risk assessment for breast/ovarian cancer are complex and requires professional explanations. ...Read more

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Dr. Barry Rosen Dr. Rosen
Surgery
30 years in practice
Northwestern University Feinberg School of Medicine
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Do brca1 and brca2 mutations affect men the same way they affect women?

Do brca1 and brca2 mutations affect men the same way they affect women?

No: The penetrance of a mutation defines the risk of developing the disease in those that carry a particular mutation. Women with brca mutations have lifetime risks estimated between 40-80%; men's risks are much less-studied but are probably in the range of 10% or less. ...Read more

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Dr. Steven Rottman Dr. Rottman
Surgery - Plastics
14 years in practice
St. George's University School of Medicine
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Who should take the brca1/brca2 test?

Who should take the brca1/brca2 test?

Know risk factors!: Genetic testing is recommended for: 1)a personal history of breast cancer at age 50 or younger 2)a personal history of triple negative breast cancer (breast cancer that is estrogen receptor-negative, Progesterone receptor-negative and her2/neu receptor-negative) 3)a personal or family history of male breast cancer 4)a personal or family history of bilateral breast cancer 5)history of ovarian cance. ...Read more

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Dr. Barry Rosen Dr. Rosen
Surgery
30 years in practice
Northwestern University Feinberg School of Medicine
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If a man is found to have brca1 or brca2 mutations, what should his next step be?

If a man is found to have brca1 or brca2 mutations, what should his next step be?

Genetic counseling: The penetrance of a mutation defines the risk of developing the disease that one is at risk for. The penetrance of the brca mutations varies between 40-80% for women and less than 10% for men, depending on the specific mutation and patient factors. The best method to prevent breast cancer at this time is to have a prophylactic bilateral mastectomy. ...Read more

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Dr. Regina Hampton Dr. Hampton
Breast Surgery
19 years in practice
Drexel University College of Medicine
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How are brca1 and brca2 related to the development of breast cancer?

How are brca1 and brca2 related to the development of breast cancer?

Very high risk: Patients who are brca positive have a very high risk of developing breast cancer. They can have an 80-90% risk (over lifetime) of developing 1 breast cancer, 50-65% chance of developing a 2nd breast cancer and a 40-50% risk of developing ovarian cancer. Please see this link for more details: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read more

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Dr. Michael Zadeh Dr. Zadeh
Surgery
13 years in practice
St. George's University School of Medicine
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What do brca1 and brca2 stand for?

What do brca1 and brca2 stand for?

BReast CAncer: The brca in brca1 and brca2 stands for breast cancer susceptibility gene. They are a type of gene known as tumor suppressor genes. ...Read more

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Dr. Matt Malkin Dr. Malkin
Anesthesiology
12 years in practice
University of Chicago Pritzker School of Medicine
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How do you perform tests for brca1 or brca2?

How do you perform tests for brca1 or brca2?

Blood test: Usually someone with breast cancer gets tested if there is an unusual family history, though it may be done more often now. Other family members may get genetic counseling and be offered the test as well. ...Read more

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Dr. Judy Mouchawar Dr. Mouchawar
Preventive Medicine
25 years in practice
McGill University Faculty of Medicine
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Brca1 and brca2 stands for?

Brca1 and brca2 stands for?

Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read more

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Dr. Sewa Legha Dr. Legha
Internal Medicine - Oncology
46 years in practice
Punjab University, Christian Medical College
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I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?

I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?

BRCA test was not av: BRCA test is not often done, unless there is strong family history of breast Cancer in multiple members. This test was not available 20 years back, so it would not have been done. But it is not to be done except in selected cases where we suspect it may be abnormal. ...Read more

Dr. Dan Fisher Dr. Fisher
Internal Medicine
23 years in practice
Uniformed Services University of the Health Sciences F. Edward Hebert School of Medicine
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Is there any risk of immuonmodulation treatment for Crohn's disease in a woman with the brca1 gene?

Is there any risk of immuonmodulation treatment for Crohn's disease in a woman with  the brca1 gene?

Jury is out.: There is no solid data on this to my knowledge. There are several potential immunomodulatory treatments ( which probably have their own independent risks ) and they are sometimes used in combination. Reports differ on risk but in general appears to be small and manageable. How this changes with brca1 ? ...Read more

Dr. James Gulley Dr. Gulley
Internal Medicine - Hematology & Oncology
22 years in practice
Loma Linda University School of Medicine
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What is the definition or description of: brca1 gene?

What is the definition or description of: brca1 gene?

Prevent cancer: The brca1 gene is a tumor suppressor gene, a gene involved in decreasing the likeliness of developing cancer. A mutation in this gene can increase the likelihood of certain cancers including breast and ovarian cancers. For more information see: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read more

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Dr. Brian Nguyen Dr. Nguyen
Obstetrics & Gynecology
7 years in practice
Warren Alpert Medical School of Brown University
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Found out I am positive for mutation in brca 1 gene advice needed please?

Found out I am positive for mutation in brca 1 gene advice needed please?

Life planning: This is something to discuss closely w/ your MD. Ovarian CA more likely w/ BRCA1 than BRCA2. Women w/ either BRCA have >50% chance of developing breast cancer. If you have it, get screened with CA-125 blood test, ultrasound, mammogram/MRI, usually starting at age 30. Surgery after childbearing includes removal of the uterus, ovaries, and fallopian tubes, as well as mastectomy. Good luck. ...Read more

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Dr. Devon Webster Dr. Webster
Internal Medicine - Oncology
18 years in practice
Stanford University School of Medicine
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What is my risk for ovarian cancer is I have the brca-1 gene?

What is my risk for ovarian cancer is I have the brca-1 gene?

54 %: Women with a brca1 mutation have a 54% of getting ovarian cancer during their lifetime. This risk can be reduced to less than 5% by having both ovaries removed. ...Read more

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Brca2 Gene (Definition)

This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make ...Read more


Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their ...Read more