Doctor insights on:
What Percent Of Women Inherit A Brca1 Or Brca2 Gene
Clarifying Q & A: In the general population, the incidence of a brca1 mutation is between 1:500 to 1:800. It is much lower for brca2. For a woman or offspring to inherit the gene from a parent who has one copy of the mutated gene, there is a 50% chance of acquiring the gene in question. It is autosomal dominant and therefore can manifest its deleterious consequences by itself without need of a second copy. ...Read more
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
Brac1 and brac2 gene: No nobody keeps track of that because these tests are done all over the world. ...Read more
Cancer risk locus: This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make decisions to protect health. ...Read more
BRCA for breast: Brca genetic mutations are for breast and ovarian cancers , for for colonic cancers apc gene, & familial non polyposis gene mutation are tested. 75% of colon cancers has no family history, best way to detect early is by regular doctor visits and colonoscopic examinations for early detection and cure. ...Read moreSee 1 more doctor answer
Can u still have endometriosis or ovarian cancer w/ a clear transvaginal ultrasound? My doc says my ovaries are normal and my tiny cyst is gone. I have tons of pelvic pain & my mom has the brca2 gene.
Yes and No: Yes: you could definitely have endometriosis with a clear ultrasound, but would not likely have an endometrioma of the ovary no: it would be pretty unlikely to have ovarian cancer with a clear ultrasound and even if you did have extremely early undetectable cancer, it would not cause pain. ...Read moreSee 2 more doctor answers
Yes: Brca1 and 2 mutation analysis is performed at myriad lab in usa. One can either use an oral swab or blood for testing. It is strongly recommended that the testing is done in the context of genetic counseling as the interpretation of the test and risk assessment for breast/ovarian cancer are complex and requires professional explanations. ...Read moreSee 1 more doctor answer
No: The penetrance of a mutation defines the risk of developing the disease in those that carry a particular mutation. Women with brca mutations have lifetime risks estimated between 40-80%; men's risks are much less-studied but are probably in the range of 10% or less. ...Read moreSee 1 more doctor answer
Know risk factors!: Genetic testing is recommended for: 1)a personal history of breast cancer at age 50 or younger 2)a personal history of triple negative breast cancer (breast cancer that is estrogen receptor-negative, Progesterone receptor-negative and her2/neu receptor-negative) 3)a personal or family history of male breast cancer 4)a personal or family history of bilateral breast cancer 5)history of ovarian cance. ...Read moreSee 1 more doctor answer
Genetic counseling: The penetrance of a mutation defines the risk of developing the disease that one is at risk for. The penetrance of the brca mutations varies between 40-80% for women and less than 10% for men, depending on the specific mutation and patient factors. The best method to prevent breast cancer at this time is to have a prophylactic bilateral mastectomy. ...Read moreSee 2 more doctor answers
Very high risk: Patients who are brca positive have a very high risk of developing breast cancer. They can have an 80-90% risk (over lifetime) of developing 1 breast cancer, 50-65% chance of developing a 2nd breast cancer and a 40-50% risk of developing ovarian cancer. Please see this link for more details: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read moreSee 1 more doctor answer
Breast cancer genes: "BR" stands for breast "CA" stands for cancer In the mid-1990s, two genes were found that are changed in many families with breast cancer. The first gene found was named BRCA1 (BReast CAncer first gene found) and the second one was named BRCA2. The search for other genes continues. ...Read moreSee 1 more doctor answer
I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?
BRCA test was not av: BRCA test is not often done, unless there is strong family history of breast Cancer in multiple members. This test was not available 20 years back, so it would not have been done. But it is not to be done except in selected cases where we suspect it may be abnormal. ...Read more
Is there any risk of immuonmodulation treatment for Crohn's disease in a woman with the brca1 gene?
Jury is out.: There is no solid data on this to my knowledge. There are several potential immunomodulatory treatments ( which probably have their own independent risks ) and they are sometimes used in combination. Reports differ on risk but in general appears to be small and manageable. How this changes with brca1 ? ...Read more
Prevent cancer: The brca1 gene is a tumor suppressor gene, a gene involved in decreasing the likeliness of developing cancer. A mutation in this gene can increase the likelihood of certain cancers including breast and ovarian cancers. For more information see: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read moreSee 2 more doctor answers
Life planning: This is something to discuss closely w/ your MD. Ovarian CA more likely w/ BRCA1 than BRCA2. Women w/ either BRCA have >50% chance of developing breast cancer. If you have it, get screened with CA-125 blood test, ultrasound, mammogram/MRI, usually starting at age 30. Surgery after childbearing includes removal of the uterus, ovaries, and fallopian tubes, as well as mastectomy. Good luck. ...Read moreSee 1 more doctor answer
This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make ...Read more
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