Doctor insights on:
What Percent Of Women Inherit A Brca1 Or Brca2 Gene
Clarifying Q & A: In the general population, the incidence of a brca1 mutation is between 1:500 to 1:800. It is much lower for brca2. For a woman or offspring to inherit the gene from a parent who has one copy of the mutated gene, there is a 50% chance of acquiring the gene in question. It is autosomal dominant and therefore can manifest its deleterious consequences by itself without need of a second copy. ...Read more
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?
50:50 inheritance: Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read moreSee 2 more doctor answers
Yes!: If you have a mutation in the brca gene, you are at higher risk of getting a first cancer, and of having recurrence of a prior treated cancer. The brca gene helps cells repair themselves when they get damanged. Cells in people with a mutated brca gene can't repair themselves, so they are more likely to become cancerous. I keep a very close eye on my cancer patients with brca mutations! ...Read moreSee 1 more doctor answer
Mutations: A chromosome will contain many genes, so a chromosome mutation will effect many genes. A gene mutation will have an effect only on that gene. ...Read more
Does a homozygous gene mutation, e.g. 1p36.3, make me more likely to have other mutations in nearby genes on the same chromosome, e.g.1p34.1?
No: Gene mutations are still being researched and from my opinion, I don't think we're even close to scratching the surface of the miraculous human genome. That being said, mutations are a normal part of our evolution. Is therea reason you're concerned? If we know, you will likely get an answer sooner. ...Read more
Not usually: On www.Angelman.Org there is an explanation of the ways in which the genetic errors that cause angelman syndrome can occur.In a very few cases, there is an alteration in mother's ub3a gene or a balanced translocation on her chromosome 15 that increases risk, but usually it's a new mutation. ...Read more
Depends: This depends on the profile of the other parent. Their are dozens of mutations that can lead to CF, although most are the delta 509. Both parents must carry a CF related gene for an offspring to get it, and if so the risk is 25%. Carrier testing is available through specialty labs.If only one has trait ,zero. ...Read moreSee 2 more doctor answers
What are the chances of passing on the Cystic Fibrosis gene if only one parent is a CARRIER? Other parent not a carrier.
What are the chances of passing on a permutation gene of huntingtons? 50/50? Anyone know a good website with statics research about the pre-mutation?
How does a person inherit hereditary deafness is it dominant or recessive genectic or chromosomal
Genetics: The hearing deficit in hereditary hearing impairment (hhi) may be present at birth (congenital), progressive from birth, or it may develop when the child is older. Approximately 80 percent of cases of hhi are inherited in an autosomal recessive pattern, 15 percent are autosomal dominant, 2 percent are x-linked (mainly recessive), and 1 percent are mitochondrial. ...Read more
Please advise how rare is a familial mutation on CYP19A1 gene in terms of excessive expression of estrogen synthase in male population. Thank you.
Look it up on Google: Google search "Familial Mutations CYP19A1". Only a single change in DNA base pares is a mutation, most changes minor in consequence, others major. Variations in genes are extremely common &, in 2014, humans are still far from tracking or understanding all variations which exist, much less genetic control mechanisms & what differences which variations make in which outcomes; Too Complex. ...Read moreSee 1 more doctor answer
Depends on Both: This depends on whether both parents carry the trait. If only one parent is a carrier of the gene, then there is no chance of inheriting cystic fibrosis. However, if both parents carry the CF gene, then there is a 25% chance their child will inherit cystic fibrosis. ...Read moreSee 1 more doctor answer
Good question. : The answer is no, a small number of patients with early onset breast cancer who carry a bad brca 1 or 2 mutation develop it "de novo", meaning that it started with them (after all, someone has to be the first to have it). Depending at which stage in development it happens, it may affect them to a different degree and may or may not be passed to their children. Some other cancer syndromes.. ...Read moreSee 1 more doctor answer
Does autosomal recessive polycystic kidney disease of one parent could be genetically transmissible to one of the children and what is the percentage?
Yes: Yes, you can have more than one genetic mutation. Most mutations do not cause significant or even visible problems. However you can have multiple serious genetic mutations. ...Read more
50%/time: Carrier parents pass either the normal or affected gene at equal(50%) frequency any time they conceive.In a million random parings, 25% would result in cf, 25% in non-carrier & 50% carriers. In practice, the parents could produce all cf, all carrier or all non- carrier kids. ...Read more
Mother had lobular breast cancer at 52-- post menopause.Negative for brca genes, atm, p53, cdh1, etc. Is there a strong likelihood i'll get it a well?
Possible: Various causes result in breast cancer in a family. If BRACA is neg then there is no genetic relationship to getting the Ca. Exposure to the MMTV virus probably results in 80% chance of having a tumor. Also recognized that endogenous sequences of virus can be passed and when proper reorganization of the sequences takes place, the viral genome can induce cancer. ...Read moreSee 1 more doctor answer
Autosomes: All but trisomy 21 will kill one before or soon after birth. People who I know suspect I have XYY; this, XXY, and XXX are famously survivable and some say XYY and XXY offer plusses. ...Read more
This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make ...Read more
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