Doctor insights on:
What Part Of The Immune System Is Involved In Organ Rejection
Innate and Adaptive: Innate or non-specific immunity involves the skin, lining of the GI tract, respiratory tract, gu tract, etc; and adaptive immunity that involves cells (primarily lymphocytes). Both types of immunity can affect the graft and trigger rejection. In addition, immune responses involve the formation of both cells and antibodies (proteins) that are reactive against the transplanted organ. ...Read moreSee 2 more doctor answers
All organs: The immune system functions to a degree in all the organs of your body. So, an infection anywhere will eventually be noticed and attacked. Certain organs, like the brain, eye, and testes are immune "privileged"--the immune cells will ignore those tissues to minimize the chance of disrupting their function. That is, unless something is seriously wrong (like a major infection). ...Read more
I'm depressed that my appendix was removed to find out it's important part of my immune system. Will my life change? I'm just scared....
Tissue markers : The tissue markers on the transplanted tissue are different from your native markers. ...Read more
Foreign proteins: Everyone has a unique genetic make up which determines the types of proteins found in our body (only identical twins have the exact same genes). Our immune systems are designed to recognize and destroy all proteins that are "foreign" (i.e. Not our own). A transplanted organ contains someone else's proteins, thus the body sees it as foreign and attacks/rejects it. Medications prevent this. ...Read moreSee 1 more doctor answer
B/c it is foreign.: A newly transplanted organ is still from another body. The immune system recognizes this as foreign because it has slightly or greatly different hla/tissue types in its cells. These are matched as well as possible before transplant, but there are usually some differences as no two peopl;e are alike. Thus, it attacks it and will kill it unless immunosuppression is done by drugs, etc. ...Read more
Is it possible to locally suppress the immune system, like only suppressing it at one gland or organ?
Foreign antigens: A person's immune system will see a replaced organ as a foreign object unless the tissues are identical (from an identical twin or tissue grown from one's own cells). To prevent rejection of the organ, doctors often have to give medications to suppress this unwanted immune response. The closer the tissues mach, there is a lower probability of the unwanted immune response. ...Read more
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